Keyword search (4,163 papers available)

"Bawa KK" Authored Publications:

Title Authors PubMed ID
1 Thermo-responsive polysulfobetaine beads crosslinked with biodegradable alginates for controlled release of agricultural pesticide Andrade-Gagnon B; Olszewski C; Bawa KK; Hemraz UD; Oh JK; 41561011
CHEMBIOCHEM
2 Fabrication of thermo-responsive multicore microcapsules using a facile extrusion process Lavertu JD; Bawa KK; Hrapovic S; Fu D; Oh JK; Hemraz UD; 38915334
CHEMBIOCHEM
3 Imidazole-Mediated Dual Location Disassembly of Acid-Degradable Intracellular Drug Delivery Block Copolymer Nanoassemblies Jazani AM; Shetty C; Movasat H; Bawa KK; Oh JK; 34050688
CHEMBIOCHEM
4 Stimulus-Responsive Degradable Polylactide-Based Block Copolymer Nanoassemblies for Controlled/Enhanced Drug Delivery. Bawa KK, Oh JK 28493712
CHEMBIOCHEM
5 PLA-Based Triblock Copolymer Micelles Exhibiting Dual Acidic pH/Reduction Responses at Dual Core and Core/Corona Interface Locations. Bawa KK, Jazani AM, Shetty C, Oh JK 30286258
CHEMBIOCHEM

 

Title:Stimulus-Responsive Degradable Polylactide-Based Block Copolymer Nanoassemblies for Controlled/Enhanced Drug Delivery.
Authors:Bawa KK,  Oh JK
Link:https://www.ncbi.nlm.nih.gov/pubmed/28493712?dopt=Abstract
Publication:
Keywords:
PMID:28493712 Category:Mol Pharm Date Added:2019-05-31
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University , Montreal, Quebec, Canada H4B 1R6.

Description:

Stimulus-Responsive Degradable Polylactide-Based Block Copolymer Nanoassemblies for Controlled/Enhanced Drug Delivery.

Mol Pharm. 2017 08 07;14(8):2460-2474

Authors: Bawa KK, Oh JK

Abstract

Polylactide (PLA) is biocompatible and FDA-approved for clinical use and thus has been a choice of the materials valuable for extensive applications in biomedical fields. However, conventionally designed PLA-based amphiphilic block copolymer (ABP) nanoassemblies exhibit slow and uncontrolled release of encapsulated drugs because of the slow biodegradation of hydrophobic PLA in physiological conditions. To improve potentials for clinical use and commercialization of conventional PLA-based nanoassemblies, stimulus-responsive degradation (SRD) platform has been introduced into the design of PLA-based nanoassemblies for enhanced/controlled release of encapsulated drugs. This review summarizes recent strategies that allow for the development of PLA-based ABPs and their self-assembled nanostructures exhibiting SRD-induced enhanced drug release. The review focuses on the design, synthesis, and evaluation of the nanoassemblies as intracellular drug delivery nanocarriers for cancer therapy. Further, the outlook is briefly discussed on the important aspects for the current and future development of more effective SRD PLA-based nanoassemblies toward tumor-targeting intracellular drug delivery.

PMID: 28493712 [PubMed - indexed for MEDLINE]




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