Keyword search (4,164 papers available)

"Brake WG" Authored Publications:

Title Authors PubMed ID
1 Combined effects of the contraceptive hormones, ethinyl estradiol and levonorgestrel, on the use of place and response memory in gonadally-intact female rats Lacasse JM; Boulos V; Fisher C; Hamilton S; Heron M; Mac Cionnaith CE; Peronace V; Tito N; Brake WG; 36403510
PSYCHOLOGY
2 Modeling hormonal contraception in female rats: a framework for studies in behavioral neurobiology Lacasse JM; Gomez-Perales E; Brake WG; 35952797
PSYCHOLOGY
3 Estrogen receptors observed at extranuclear neuronal sites and in glia in the nucleus accumbens core and shell of the female rat: Evidence for localization to catecholaminergic and GABAergic neurons Almey A; Milner TA; Brake WG; 35397175
CSBN
4 Progesterone rapidly alters the use of place and response memory during spatial navigation in female rats Lacasse JM; Patel S; Bailey A; Peronace V; Brake WG; 35158200
PSYCHOLOGY
5 Depression, Estrogens, and Neuroinflammation: A Preclinical Review of Ketamine Treatment for Mood Disorders in Women Gagne C; Piot A; Brake WG; 35115970
CSBN
6 The priming effect of food persists following blockade of dopamine receptors. Evangelista C, Hantson A, Shams WM, Almey A, Pileggi M, Voisard JR, Boulos V, Al-Qadri Y, Gonzalez Cautela BV, Zhou FX, Duchemin J, Habrich A, Tito N, Koumrouyan RA, Patel S, Lorenc V, Gagne C, El Oufi K, Shizgal P, Brake WG 31350860
CSBN
7 Estrogen receptor α and G-protein coupled estrogen receptor 1 are localized to GABAergic neurons in the dorsal striatum. Almey A, Milner TA, Brake WG 27080432
PSYCHOLOGY
8 High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats. Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG 27154458
CSBN
9 Modulation of spatial and response strategies by phase of the menstrual cycle in women tested in a virtual navigation task. Hussain D, Hanafi S, Konishi K, Brake WG, Bohbot VD 27213559
PSYCHOLOGY
10 17β-Estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo. Shams WM, Sanio C, Quinlan MG, Brake WG 27256507
PSYCHOLOGY
11 Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats. Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG 28062232
PSYCHOLOGY
12 17β-estradiol locally increases phasic dopamine release in the dorsal striatum. Shams WM, Cossette MP, Shizgal P, Brake WG 29175028
CSBN
13 Modulatory effect of 17-β estradiol on performance of ovariectomized rats on the Shock-Probe test. Gervais NJ, Jacob S, Brake WG, Mumby DG 24768650
PSYCHOLOGY
14 Changes in brain volume in response to estradiol levels, amphetamine sensitization and haloperidol treatment in awake female rats. Madularu D, Kulkarni P, Ferris CF, Brake WG 26032742
CSBN
15 Attenuation of dendritic spine density in the perirhinal cortex following 17β-Estradiol replacement in the rat. Gervais NJ, Mumby DG, Brake WG 26104963
CSBN
16 Ovarian steroids alter dopamine receptor populations in the medial preoptic area of female rats: implications for sexual motivation, desire, and behaviour. Graham MD, Gardner Gregory J, Hussain D, Brake WG, Pfaus JG 26536143
PSYCHOLOGY
17 High Oestradiol Replacement Reverses Response Memory Bias in Ovariectomised Female Rats Regardless of Dopamine Levels in the Dorsal Striatum. Hussain D, Cossette MP, Brake WG 26929121
PSYCHOLOGY
18 Intra-perirhinal cortex administration of estradiol, but not an ERβ agonist, modulates object-recognition memory in ovariectomized rats. Gervais NJ, Hamel LM, Brake WG, Mumby DG 27321161
PSYCHOLOGY
19 Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatum Minogianis EA; Shams WM; Mabrouk OS; Wong JT; Brake WG; Kennedy RT; du Souich P; Samaha AN; 29757478
MASSSPEC

 

Title:Changes in brain volume in response to estradiol levels, amphetamine sensitization and haloperidol treatment in awake female rats.
Authors:Madularu D,  Kulkarni P,  Ferris CF,  Brake WG
Link:https://www.ncbi.nlm.nih.gov/pubmed/26032742?dopt=Abstract
Publication:
Keywords:
PMID:26032742 Category:Brain Res Date Added:2019-05-31
Dept Affiliation: CSBN
1 Concordia University, Department of Psychology, Center for Studies in Behavioral Neurobiology, 7141 Sherbrooke St. West, Montréal, QC, Canada H4B 1R6. Electronic address: dan.madularu@gmail.com.
2 Northeastern University, Department of Psychology, Center for Translational Neuroimaging, 360 Huntington Ave., Boston, 02115 MA, USA.
3 Concordia University, Department of Psychology, Center for Studies in Behavioral Neurobiology, 7141 Sherbrooke St. West, Montréal, QC, Canada H4B 1R6.

Description:

Changes in brain volume in response to estradiol levels, amphetamine sensitization and haloperidol treatment in awake female rats.

Brain Res. 2015 Aug 27;1618:100-10

Authors: Madularu D, Kulkarni P, Ferris CF, Brake WG

Abstract

Estrogen has been shown to further ameliorate symptoms when administered in conjunction with antipsychotics in patients with schizophrenia. We have previously shown that chronic haloperidol (HAL) treatment reduces amphetamine (AMPH)-induced locomotor activity in AMPH-sensitized rats, but only when paired with high levels of the estrogen, 17-ß estradiol. In addition, we reported estradiol-dependent responses to AMPH in AMPH-sensitized rats as measured by functional magnetic resonance imaging. It is thus clear that estradiol and antipsychotics both affect the rat brain, however the mechanism by which this occurs is unknown. The aim of the current study was to assess this interaction by investigating the effects of estradiol, AMPH and HAL on brain volume changes in awake female rats. Repeated exposure to AMPH resulted in an overall reduction in brain volume, regardless of hormonal status (i.e. no, low or high estradiol). Similarly, chronic HAL treatment further reduced brain volume compared to acute treatment. Hormonal status affected hippocampal volume with rats receiving low estradiol replacement showing larger volume; this difference was no longer significant after repeated exposure to AMPH. Finally, we found changes in volume in response to AMPH throughout hippocampal components (i.e. CA1-CA3 and dentate) as well as components of the mesocortical system. In conclusion, brain volume seems to be influenced by hormonal status, as well as exposure to AMPH and haloperidol treatment. These findings implicate areas where estradiol, amphetamine and antipsychotics may be producing volumetric changes in the brain, pointing the way to where future studies should focus.

PMID: 26032742 [PubMed - indexed for MEDLINE]




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