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PubMed Publications| Keyword search (4,163 papers available) |  |
"Cox SML" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography | Nikolic M; Cox SML; Jaworska N; Castellanos-Ryan N; Dagher A; Vitaro F; Brendgen M; Parent S; Boivin M; Côté S; Tremblay RE; Séguin JR; Leyton M; | 39725679 CSBN |
| 2 | Mesocorticolimbic function in cocaine polydrug users: A multimodal study of drug cue reactivity and cognitive regulation | Scala SG; Kang MS; Cox SML; Rosa-Neto P; Massarweh G; Leyton M; | 38221806 CSBN |
| 3 | Cocaine cue-induced mesocorticolimbic activation in cocaine users: Effects of personality traits, lifetime drug use, and acute stimulant ingestion | D' Amour-Horvat V; Cox SML; Dagher A; Kolivakis T; Jaworska N; Leyton M; | 34463411 CSBN |
| 4 | mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use. | Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M | 32413893 CSBN |
| 5 | Extra-striatal D2/3 receptor availability in youth at risk for addiction. | Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Séguin JR, Leyton M | 32259831 CSBN |
| 6 | Effect of (Z)-isomer content on [11C]ABP688 binding potential in humans. | Smart K, Cox SML, Kostikov A, Shalai A, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M | 30607444 CSBN |
| 7 | Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors. | Smart K, Cox SML, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M | 30627817 CSBN |
| Title: | A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography | ||||
| Authors: | Nikolic M, Cox SML, Jaworska N, Castellanos-Ryan N, Dagher A, Vitaro F, Brendgen M, Parent S, Boivin M, Côté S, Tremblay RE, Séguin JR, Leyton M | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/39725679/ | ||||
| DOI: | 10.1111/acer.15511 | ||||
| Publication: | Alcohol, clinical & experimental research | ||||
| Keywords: | addiction; biomarker; endophenotype; reward processing; | ||||
| PMID: | 39725679 | Category: | Date Added: | 2024-12-27 | |
| Dept Affiliation: |
CSBN
1 Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada. 2 Department of Psychiatry, McGill University, Montreal, Quebec, Canada. 3 Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada. 4 Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada. 5 School of Psychoeducation, Université de Montréal, Montreal, Quebec, Canada. 6 Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. 7 Azrieli Research Center of the CHU Ste-Justine, Montreal, Quebec, Canada. 8 Department of Psychology, Université de Québec à Montréal, Montreal, Quebec, Canada. 9 Department of Psychology, Université Laval, Quebec, Quebec, Canada. 10 Institute of Genetic, Neurobiological and Social Foundations of Child Development, Tomsk State University, Tomsk, Russia. 11 Department of Social & Preventative Medicine, Université de Montréal, Montreal, Quebec, Canada. 12 Department of Pediatrics, Université de Montréal, Montreal, Quebec, Canada. 13 Department of Psychology, Université de Montréal, Montreal, Quebec, Canada. 14 School of Public Health and Sports Science, University College Dublin, Dublin, Ireland. 15 INSERM, U669, Paris, France. 16 Department of Psychiatry and Addictology, Université de Montréal, Montreal, Quebec, Canada. 17 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada. |
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Description: |
Background: Adolescent alcohol use is the norm, but only some develop a substance use disorder. The increased risk might reflect heightened mesocorticolimbic responses to reward-related cues but results published to date have been inconsistent. Methods: Young social drinkers (age 18.5 ± 0.6 y.o.) who have been followed since birth were recruited from high- versus low-risk trajectories based on externalizing (EXT) behavioral traits. All had functional magnetic resonance imaging (fMRI) scans to measure mesocorticolimbic responses to alcohol, juice, and water cues (High EXT: 20F/10M; Low EXT: 15F/12M). Most had positron emission tomography (PET) [18F]fallypride scans to measure brain regional dopamine D2 receptor availabilities (n = 47). Results: Compared with the low EXT group, high EXT participants reported larger subjective responses to the alcohol and juice cues (vs. water). Despite this, a main effect of group was not seen for brain activation responses to the alcohol and juice cues. Instead, low EXT participants exhibited higher mesocorticolimbic activations to alcohol than juice, whereas these activations did not differ in the high EXT group. Across all participants, alcohol (vs. water) blood oxygen level-dependent (BOLD) responses in the striatum and amygdala were associated with midbrain [18F]fallypride BPND values. Conclusion: Young social drinkers at high versus low risk for substance use disorders did not exhibit larger mesocorticolimbic BOLD activations to alcohol-related cues and their responses poorly differentiated alcohol from juice. These observations raise the possibility that (i) diminished mesocorticolimbic BOLD differentiations between reward-related cues might be a marker of increased risk for substance use disorders, and (ii) previously reported large BOLD responses to drug-related cues in people with substance use disorders might better identify the disease than pre-existing vulnerability. |
