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PubMed Publications| Keyword search (4,163 papers available) |  |
"Cross NE" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Effects of cognitive-behavioral therapy for insomnia during sedative-hypnotics withdrawal on sleep and cognition in older adults | Barbaux L; Cross NE; Perrault AA; Es-Sounni M; Desrosiers C; Clerc D; Andriamampionona F; Lussier D; Tannenbaum C; Guimond A; Grenier S; Gouin JP; Dang-Vu TT; | 41092866 SOH |
| 2 | Identification of five sleep-biopsychosocial profiles with specific neural signatures linking sleep variability with health, cognition, and lifestyle factors | Perrault AA; Kebets V; Kuek NMY; Cross NE; Tesfaye R; Pomares FB; Li J; Chee MWL; Dang-Vu TT; Yeo BTT; | 41056215 HKAP |
| 3 | Effect of chronic benzodiazepine and benzodiazepine receptor agonist use on sleep architecture and brain oscillations in older adults with chronic insomnia | Barbaux L; Perrault AA; Cross NE; Weiner OM; Es-Sounni M; Pomares FB; Tarelli L; McCarthy M; Maltezos A; Smith D; Gong K; O' Byrne J; Yue V; Desrosiers C; Clerc D; Andriamampionona F; Lussier D; Gilbert S; Tannenbaum C; Gouin JP; Dang-Vu TT; | 40570297 CSBN |
| 4 | NREM sleep brain networks modulate cognitive recovery from sleep deprivation | Lee K; Wang Y; Cross NE; Jegou A; Razavipour F; Pomares FB; Perrault AA; Nguyen A; Aydin Ü; Uji M; Abdallah C; Anticevic A; Frauscher B; Benali H; Dang-Vu TT; Grova C; | 39005401 PERFORM |
| 5 | A multidimensional investigation of sleep and biopsychosocial profiles with associated neural signatures | Perrault AA; Kebets V; Kuek NMY; Cross NE; Tesfaye R; Pomares FB; Li J; Chee MWL; Dang-Vu TT; Yeo BTT; | 38659875 HKAP |
| 6 | A multidimensional investigation of sleep and biopsychosocialprofiles with associated neural signatures | Perrault AA; Kebets V; Kuek NMY; Cross NE; Tesfaye R; Pomares FB; Li J; Chee MWL; Dang-Vu TT; Thomas Yeo BT; | 38559143 HKAP |
| 7 | Methodological approach to sleep state misperception in insomnia disorder: Comparison between multiple nights of actigraphy recordings and a single night of polysomnography recording | Maltezos A; Perrault AA; Walsh NA; Phillips EM; Gong K; Tarelli L; Smith D; Cross NE; Pomares FB; Gouin JP; Dang-Vu TT; | 38325157 HKAP |
| 8 | Effects of cognitive behavioral therapy for insomnia on subjective and objective measures of sleep and cognition | Perrault AA; Pomares FB; Smith D; Cross NE; Gong K; Maltezos A; McCarthy M; Madigan E; Tarelli L; McGrath JJ; Savard J; Schwartz S; Gouin JP; Dang-Vu TT; | 35691208 PERFORM |
| 9 | CPAP for Cognition in Sleep Apnea and Mild Cognitive Impairment: A Pilot Randomised Cross-Over Trial | Hoyos CM; Cross NE; Terpening Z; D' Rozario AL; Yee BJ; LaMonica H; Marshall NS; Grunstein RR; Naismith SL; | 35584294 CSBN |
| 10 | An altered balance of integrated and segregated brain activity is a marker of cognitive deficits following sleep deprivation | Cross NE; Pomares FB; Nguyen A; Perrault AA; Jegou A; Uji M; Lee K; Razavipour F; Ali OBK; Aydin U; Benali H; Grova C; Dang-Vu TT; | 34735431 PERFORM |
| 11 | More than a quarter century of the most prescribed sleeping pill: Systematic review of zolpidem use by older adults. | Machado FV, Louzada LL, Cross NE, Camargos EF, Dang-Vu TT, Nóbrega OT | 32360985 PERFORM |
| 12 | Association between insomnia disorder and cognitive function in middle-aged and older adults: a cross-sectional analysis of the Canadian Longitudinal Study on Aging | Cross NE; Carrier J; Postuma RB; Gosselin N; Kakinami L; Thompson C; Chouchou F; Dang-Vu TT; | 31089710 PERFORM |
| Title: | Effect of chronic benzodiazepine and benzodiazepine receptor agonist use on sleep architecture and brain oscillations in older adults with chronic insomnia | ||||
| Authors: | Barbaux L, Perrault AA, Cross NE, Weiner OM, Es-Sounni M, Pomares FB, Tarelli L, McCarthy M, Maltezos A, Smith D, Gong K, O', Byrne J, Yue V, Desrosiers C, Clerc D, Andriamampionona F, Lussier D, Gilbert S, Tannenbaum C, Gouin JP, Dang-Vu TT | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40570297/ | ||||
| DOI: | 10.1093/sleep/zsaf168 | ||||
| Publication: | Sleep | ||||
| Keywords: | aging; benzodiazepine; brain oscillations; sleep; | ||||
| PMID: | 40570297 | Category: | Date Added: | 2025-06-26 | |
| Dept Affiliation: |
CSBN
1 Sleep, Cognition and Neuroimaging Lab, Department of Health, Kinesiology and Applied Physiology, School of Health & Center for Studies in Behavioural Neurobiology, Concordia University, Montreal, QC, Canada. 2 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, CIUSSS Centre-Sud-de-l'Ile-de-Montréal, Québec, Canada. 3 Sleep and Circadian Group, Woolcock Institute of Medical Research, Macquarie University, Sydney, NSW, Australia. 4 School of Psychology, University of Sydney, NSW, Australia. 5 Statistics Canada Biobank, Statistics Canada, ON, Canada. 6 Department of Psychology, Université de Montréal, Montreal, QC, Canada. 7 Stress, Interpersonal Relationship and Health Lab, Department of Psychology & Centre for Clinical Research in Health, Concordia University, Quebec, Canada. |
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Description: |
Study objectives: Insomnia in older adults is associated with widespread benzodiazepine (BZD) and benzodiazepine receptor agonist (BZRA) use, despite evidence that chronic use disrupts sleep regulation and cognition. Little is known about BZD/BZRA effects on NREM slow oscillations (SO), spindles and their coupling, which is crucial for memory, in older adults. Our objective was to investigate the effects of chronic BZD/BZRA use on sleep macro-architecture, EEG relative power, SO and spindle characteristics and coupling. Methods: After habituation polysomnography (PSG), second-night data were analyzed from 101 participants (66.05 ± 5.84 years, range: 55-80 years, 73% female) were categorized into three groups: good sleepers (GS, n = 28), individuals with insomnia (INS, n = 26) or individuals with insomnia who chronically use BZD/BZRA (MED, n = 47; diazepam equivalent: 6.1 ± 3.8 mg per use; >3 nights/week). We performed a comprehensive comparison of sleep architecture, EEG relative spectrum, and associated brain oscillatory activities, focusing on SO and spindles, and their temporal coupling. Results: MED showed disrupted sleep architecture with lower N3 and higher N1 duration and spectral activity, and altered sleep-related brain oscillations synchrony, compared to INS and GS. An exploratory interaction model suggested that chronic use of higher doses (mg per use) correlated with more pronounced disruptions in sleep micro-architecture and EEG spectrum. Conclusions: Our results suggest that chronic BZD and BZRA use is associated with poorer sleep quality. Such alteration of sleep regulation - at the macro and micro-architectural levels - may contribute to the reported association between BZD/BZRA use and cognitive impairment in older adults. |
