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PubMed Publications| Keyword search (4,164 papers available) |  |
"Dagher A" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan | Farahani A; Liu ZQ; Ceballos EG; Hansen JY; Wennberg K; Zeighami Y; Dadar M; Gauthier CJ; Dagher A; Misic B; | 40729400 PHYSICS |
| 2 | A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography | Nikolic M; Cox SML; Jaworska N; Castellanos-Ryan N; Dagher A; Vitaro F; Brendgen M; Parent S; Boivin M; Côté S; Tremblay RE; Séguin JR; Leyton M; | 39725679 CSBN |
| 3 | A dataset of multi-contrast unbiased average MRI templates of a Parkinson's disease population | Madge V; Fonov VS; Xiao Y; Zou L; Jackson C; Postuma RB; Dagher A; Fon EA; Collins DL; | 37213552 IMAGING |
| 4 | Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain | Hansen JY; Markello RD; Tuominen L; Nørgaard M; Kuzmin E; Palomero-Gallagher N; Dagher A; Misic B; | 36209794 CSBN |
| 5 | Normal cognition in Parkinson's disease may involve hippocampal cholinergic compensation: An exploratory PET imaging study with [(18)F]-FEOBV | Legault-Denis C; Aghourian M; Soucy JP; Rosa-Neto P; Dagher A; Aumont E; Wickens R; Bedard MA; | 34628195 PERFORM |
| 6 | Cocaine cue-induced mesocorticolimbic activation in cocaine users: Effects of personality traits, lifetime drug use, and acute stimulant ingestion | D' Amour-Horvat V; Cox SML; Dagher A; Kolivakis T; Jaworska N; Leyton M; | 34463411 CSBN |
| 7 | mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use. | Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M | 32413893 CSBN |
| 8 | Extra-striatal D2/3 receptor availability in youth at risk for addiction. | Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Séguin JR, Leyton M | 32259831 CSBN |
| 9 | Cocaine cue-induced dopamine release in the human prefrontal cortex. | Milella MS, Fotros A, Gravel P, Casey KF, Larcher K, Verhaeghe JA, Cox SM, Reader AJ, Dagher A, Benkelfat C, Leyton M | 26900792 CSBN |
| 10 | Cyberinfrastructure for Open Science at the Montreal Neurological Institute. | Das S, Glatard T, Rogers C, Saigle J, Paiva S, MacIntyre L, Safi-Harab M, Rousseau ME, Stirling J, Khalili-Mahani N, MacFarlane D, Kostopoulos P, Rioux P, Madjar C, Lecours-Boucher X, Vanamala S, Adalat R, Mohaddes Z, Fonov VS, Milot S, Leppert I, Degroot C, Durcan TM, Campbell T, Moreau J, Dagher A, Collins DL, Karamchandani J, Bar-Or A, Fon EA, Hoge R, Baillet S, Rouleau G, Evans AC | 28111547 IMAGING |
| 11 | Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers. | Booij L, Welfeld K, Leyton M, Dagher A, Boileau I, Sibon I, Baker GB, Diksic M, Soucy JP, Pruessner JC, Cawley-Fiset E, Casey KF, Benkelfat C | 26905412 PSYCHOLOGY |
| Title: | Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain | ||||
| Authors: | Hansen JY, Markello RD, Tuominen L, Nørgaard M, Kuzmin E, Palomero-Gallagher N, Dagher A, Misic B | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/36209794/ | ||||
| DOI: | 10.1016/j.neuroimage.2022.119671 | ||||
| Publication: | NeuroImage | ||||
| Keywords: | |||||
| PMID: | 36209794 | Category: | Date Added: | 2022-10-10 | |
| Dept Affiliation: |
CSBN
1 McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, Canada. Electronic address: justine.hansen@mail.mcgill.ca. 2 McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, Canada. 3 Department of Psychiatry, The Royal's Institute of Mental Health Research, University of Ottawa, ON, Canada. 4 Neurobiology Research Unit & CIMBI, Copenhagen University Hospital, Copenhagen, Denmark; Center for Reproducible Neuroscience, Department of Psychology, Stanford University, Stanford, California, USA. 5 Department of Biology, Centre for Applied Synthetic Biology, Concordia University, Montréal, Canada; Department of Human Genetics, Rosalind & Morris Goodman Cancer Institute, McGill University, Montréal, Canada. 6 Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH, Aachen, Germany; C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. 7 McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, Canada. Electronic address: bratislav.misic@mcgill.ca. |
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Description: |
Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter receptors and transporters play a key role in shaping brain function. Due to the lack of comprehensive neurotransmitter receptor/transporter density datasets, microarray gene expression measuring mRNA transcripts is often used as a proxy for receptor densities. In the present report, we comprehensively test the spatial correlation between gene expression and protein density for a total of 27 neurotransmitter receptors, receptor binding-sites, and transporters across 9 different neurotransmitter systems, using both PET and autoradiography radioligand-based imaging modalities. We find poor spatial correspondences between gene expression and density for all neurotransmitter receptors and transporters except four single-protein metabotropic receptors (5-HT1A, CB1, D2, and MOR). These expression-density associations are related to gene differential stability and can vary between cortical and subcortical structures. Altogether, we recommend using direct measures of receptor and transporter density when relating neurotransmitter systems to brain structure and function. |
