PERFORM Publications

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Title		Authors	PubMed ID
1	The BDNF Val66Met polymorphism and health-related quality of life in youth with obesity	Goldfield GS; Cameron JD; Sigal RJ; Kenny GP; Prud' homme D; Ngu M; Alberga AS; Doucette S; Goldfield DB; Tulloch H; Thai H; Simas KR; Walsh J;	38997217 HKAP
2	Effects of the HEARTY exercise randomized controlled trial on eating behaviors in adolescents with obesity	Alberga AS; Edache IY; Sigal RJ; von Ranson KM; Russell-Mayhew S; Kenny GP; Doucette S; Prud' homme D; Hadjiyannakis S; Cameron JD; Goldfield GS;	37034563 HKAP
3	Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study	Goldfield GS; Walsh J; Sigal RJ; Kenny GP; Hadjiyannakis S; De Lisio M; Ngu M; Prud' homme D; Alberga AS; Doucette S; Goldfield DB; Cameron JD;	34867148 IMAGING
4	Understanding low adherence to an exercise program for adolescents with obesity: the HEARTY trial.	Alberga AS, Sigal RJ, Sweet SN, Doucette S, Russell-Mayhew S, Tulloch H, Kenny GP, Prud'homme D, Hadjiyannakis S, Goldfield GS	31687168 HKAP
5	Edmonton Obesity Staging System for Pediatrics, quality of life and fitness in adolescents with obesity.	Kakon GA, Hadjiyannakis S, Sigal RJ, Doucette S, Goldfield GS, Kenny GP, Prud'homme D, Buchholz A, Lamb M, Alberga AS	31687169 HKAP
6	Early parent-child relationships and risk of mood disorder in a Canadian sample of offspring of a parent with bipolar disorder: findings from a 16-year prospective cohort study.	Doucette S, Levy A, Flowerdew G, Horrocks J, Grof P, Ellenbogen M, Duffy A	25356767 PSYCHOLOGY
7	Corrigendum to "Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial" Physiology & Behavior, Volume 191, 1 July 2018, Pages 138-145.	Goldfield GS, Kenny GP, Prud'homme D, Holcik M, Alberga AS, Fahnestock M, Cameron JD, Doucette S, Hadjiyannakis S, Tulloch H, Tremblay MS, Walsh J, Guerin E, Gunnell KE, D'Angiulli A, Sigal RJ	30428994 PSYCHOLOGY
8	Changes in the Brain-Derived Neurotrophic Factor Are Associated with Improvements in Diabetes Risk Factors after Exercise Training in Adolescents with Obesity: The HEARTY Randomized Controlled Trial.	Walsh JJ, D'Angiulli A, Cameron JD, Sigal RJ, Kenny GP, Holcik M, Doucette S, Alberga AS, Prud'homme D, Hadjiyannakis S, Gunnell K, Goldfield GS	30363954 HKAP
9	Interindividual variability and individual responses to exercise training in adolescents with obesity.	Walsh JJ, Bonafiglia JT, Goldfield GS, Sigal RJ, Kenny GP, Doucette S, Hadjiyannakis S, Alberga AS, Prud'homme D, Gurd BJ	31121100 HKAP

Title:	Early parent-child relationships and risk of mood disorder in a Canadian sample of offspring of a parent with bipolar disorder: findings from a 16-year prospective cohort study.
Authors:	Doucette S, Levy A, Flowerdew G, Horrocks J, Grof P, Ellenbogen M, Duffy A
Link:	https://www.ncbi.nlm.nih.gov/pubmed/25356767?dopt=Abstract
DOI:	10.1111/eip.12195
Publication:	Early intervention in psychiatry
Keywords:	bipolar disorder; early development; high-risk; mood disorder; psychosocial;
PMID:	25356767	Category:	Early Interv Psychiatry	Date Added:	2019-06-07
Dept Affiliation:	PSYCHOLOGY 1 Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada. 2 Department of Mathematics and Statistics, University of Guelph, Guelph, Ontario, Canada. 3 Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. 4 Mood Disorders Centre of Ottawa, Ottawa University Health Services, Ottawa, Ontario, Canada. 5 Department of Psychology, Concordia University, Montreal, Quebec, Canada. 6 Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada. acduffy@ucalgary.ca. 7 Mood Disorders Centre of Ottawa, Ottawa University Health Services, Ottawa, Ontario, Canada. acduffy@ucalgary.ca. 8 Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada. acduffy@ucalgary.ca.

Description:

Early parent-child relationships and risk of mood disorder in a Canadian sample of offspring of a parent with bipolar disorder: findings from a 16-year prospective cohort study.

Early Interv Psychiatry. 2016 10;10(5):381-9

Authors: Doucette S, Levy A, Flowerdew G, Horrocks J, Grof P, Ellenbogen M, Duffy A

Abstract

AIM: Exposure to parental bipolar disorder (BD) early in life may increase the risk of developing a mood disorder. However, the impact of early parent-child relationships when a parent is affected and how this impacts an offspring's risk remains unclear. The primary objective of this study was to determine the association between parent-child relationships and risk of mood disorder in offspring of parents with BD and, secondly, to determine the interaction of temperament and life stress on this association.

METHODS: Two hundred and thirty-three offspring completed annual clinical assessments following Kiddie Schedule for Affective Disorders (KSADS) format interviews as part of an ongoing Canadian prospective cohort study conducted from 1996 to 2013. Offspring completed measures of early adversity, life stress and temperament. Clinical data from the affected parents were prospectively collected over the first decade of their offspring's life using SADS format interviews.

RESULTS: Higher perceived neglect from mother and offspring emotionality were significantly associated with the hazard of mood disorder (hazard ratio (HR): 1.1, 95% confidence interval (CI): 1.0-1.2 and HR: 1.7, 95% CI: 1.0-3.1, respectively). Duration of exposure to parental BD significantly interacted with offspring emotionality to predict mood disorder (P?=?0.01). Further, perceived neglect from mother was associated with offspring high emotionality (P?=?0.02).

CONCLUSIONS: Neglect from mother is a significant early predictor of mood disorder in offspring at familial risk for BD and may increase emotional sensitivity. Psychosocial support and interventions for high-risk families could be beneficial in reducing early adversity, maternal neglect and the risk of subsequent mood disorders in offspring.

PMID: 25356767 [PubMed - indexed for MEDLINE]

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