Keyword search (4,163 papers available)

"Esber GR" Authored Publications:

Title Authors PubMed ID
1 Different behavioral measures of conditioned magazine activity can tell different stories about brain function Volz S; Loewinger G; Marquez I; Fevola S; Kang M; Reverte I; Krishnan A; Gardner MPH; Iordanova MD; Esber GR; 41922165
CSBN
2 Reduction in reward-driven behaviour depends on the basolateral but not central nucleus of the amygdala in female rats Lay BPP; Esber GR; Iordanova MD; 40925675
PSYCHOLOGY
3 Disentangling prediction error and value in a formal test of dopamine s role in reinforcement learning Usypchuk AA; Maes EJP; Lozzi M; Avramidis DK; Schoenbaum G; Esber GR; Gardner MPH; Iordanova MD; 40738112
CSBN
4 The immunomodulatory effect of oral NaHCO3 is mediated by the splenic nerve: multivariate impact revealed by artificial neural networks Alvarez MR; Alkaissi H; Rieger AM; Esber GR; Acosta ME; Stephenson SI; Maurice AV; Valencia LMR; Roman CA; Alarcon JM; 38549144
CSBN
5 OFC neurons do not represent the negative value of a conditioned inhibitor Esber GR; Usypchuk A; Saini S; Deroche M; Iordanova MD; Schoenbaum G; 38042330
CONCORDIA
6 The Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala During the First Extinction Episode Has Persistent Effects on Extinction Expression Lay BPP; Koya E; Hope BT; Esber GR; Iordanova MD; 36336498
PSYCHOLOGY
7 Correction to: Persistent disruption of overexpectation learning after inactivation of the lateral orbitofrontal cortex in male rats Lay BPP; Choudhury R; Esber GR; Iordanova MD; 36006415
PSYCHOLOGY
8 Experimental chambers Persistent disruption of overexpectation learning after inactivation of the lateral orbitofrontal cortex in male rats Lay BPP; Choudhury R; Esber GR; Iordanova MD; 35932299
PSYCHOLOGY
9 Agency rescues competition for credit assignment among predictive cues from adverse learning conditions Kang M; Reverte I; Volz S; Kaufman K; Fevola S; Matarazzo A; Alhazmi FH; Marquez I; Iordanova MD; Esber GR; 34376741
PSYCHOLOGY
10 Different methods of fear reduction are supported by distinct cortical substrates. Lay BP, Pitaru AA, Boulianne N, Esber GR, Iordanova MD 32589138
PSYCHOLOGY
11 A self-initiated cue-reward learning procedure for neural recording in rodents. Reverte I, Volz S, Alhazmi FH, Kang M, Kaufman K, Chan S, Jou C, Iordanova MD, Esber GR 32135212
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12 Neural correlates of two different types of extinction learning in the amygdala central nucleus. Iordanova MD, Deroche ML, Esber GR, Schoenbaum G 27531638
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13 Dissociation of Appetitive Overexpectation and Extinction in the Infralimic Cortex. Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD 30371757
CSBN
14 Corrigendum: Dissociation of Appetitive Overexpectation and Extinction in the Infralimbic Cortex. Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD 30590441
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15 The serial blocking effect: a testbed for the neural mechanisms of temporal-difference learning. Mahmud A; Petrov P; Esber GR; Iordanova MD; 30979910
CSBN

 

Title:Different behavioral measures of conditioned magazine activity can tell different stories about brain function
Authors:Volz SLoewinger GMarquez IFevola SKang MReverte IKrishnan AGardner MPHIordanova MDEsber GR
Link:https://pubmed.ncbi.nlm.nih.gov/41922165/
DOI:10.1523/ENEURO.0560-24.2026
Publication:eNeuro
Keywords:
PMID:41922165 Category: Date Added:2026-04-02
Dept Affiliation: CSBN
1 Brooklyn College, City University of New York, Department of Psychology, 2900 Bedford Ave, Brooklyn, NY, 11210.
2 Machine Learning Team, National Institute of Mental Health, NIH, Bethesda, MD.
3 Department of Medical and Life Sciences & Department of Psychology, La Ciénaga University Center, University of Guadalajara, Ocotlán, Mexico.
4 The Graduate Center, City University of New York, 365 5th Ave, New York, NY, 10016.
5 Sapienza University of Rome, Dept. of Physiology and Pharmacology, Piazzale Aldo Moro 5, 00185, Roma, Italia.
6 Concordia University, Department of Psychology, CSBN/GRNC, 7141 Sherbrooke St., W. Montreal H4B 1R6.

Description:

Elucidating the neural substrates of Pavlovian reward learning requires reliable behavioral readouts. In conditioned magazine approach studies, rodents express reward expectancy by approaching the food magazine during cues that predict reward. This behavior is typically quantified using one of three measures: number of head entries, percentage of time in the magazine, or latency to respond. Yet these measures often diverge within the same discrimination task, making reliance on a single metric problematic. At the individual level, some animals express discrimination learning most clearly in one measure while showing little or no learning in the others, and animals may even switch their preferred measure across training. Reporting only one measure therefore risks underestimating the ability of a subset of animals. At the group level, sampling error can produce apparent differences across replications of the same design, limiting replicability. Moreover, brain manipulations can alter response topography, such that choosing one measure over another may lead to conflicting interpretations of neural function. To address this issue, we recommend reporting all raw behavioral measures and supplementing them with a dimensionality-reduction approach such as principal component analysis (PCA). Across multiple discrimination tasks in rats from both sexes, we show that subject-specific first principal component (PC1) scores provide a composite index that more consistently reflects discrimination learning than any single raw measure. This approach enhances statistical power, improves reproducibility, and helps distinguish true learning deficits from changes in response topography. However, its broader application will require continued validation and careful consideration of its inherent methodological trade-offs.Significance Statement Accurately characterizing Pavlovian reward learning requires reliable measurement of individual behavioral responses. In conditioned magazine approach studies, behavior is typically quantified by a single measure-such as head entries, time at the magazine, or response latency-but these measures often diverge. Reliance on one metric can underestimate discrimination ability, compromise reproducibility, and distort interpretations of neural manipulations. We show that applying principal component analysis (PCA) to integrate multiple response measures yields a robust discrimination index that better reflects individual performance. This approach increases effect sizes, strengthens replicability, and reduces misinterpretation, providing scientific, economic, and ethical benefits for research on cue-reward learning.





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