Keyword search (4,163 papers available)

"Forgione P" Authored Publications:

Title Authors PubMed ID
1 Regioselective Stepwise Synthesis of Unsymmetrical 1,2,5-Triarylpyrroles via Palladium-Catalyzed Decarboxylative Cross-Coupling and C-H Arylation Buonomano C; Patterson S; Ngou JS; Messina C; Taylor S; Bilodeau F; Forgione P; 41900086
CHEMBIOCHEM
2 A Modular and Regioselective Synthesis of Di- and Triarylated Thiophenes: Strategies for Accessing Challenging Isomeric Motifs Messina C; McKibbon K; Wong KS; Prevost P; Petkov V; Forgione P; 41160050
CONCORDIA
3 In vitro evaluation of isatin-pyridine oxime hybrids as potential acetylcholinesterase inhibitors for nerve agent prophylaxis Silva MCJD; Pinto AMV; Balthar MA; Correa ABA; Bhattacharyya D; Simas ABC; Kuca K; Forgione P; França TCC; Cavalcante SFA; Kitagawa DAS; 40516590
CHEMBIOCHEM
4 A Modular and Catalytic Methodology To Access 2,5-Furan-Based Phenylene/Thiophene Oligomers through a One-Pot Decarboxylative Cross-Coupling from 5-Bromofurfural Cigana B; Lapointe V; Majewski MB; Forgione P; 38808994
CHEMBIOCHEM
5 Sterically-Hindered Molecular p-Dopants Promote Integer Charge Transfer in Organic Semiconductors Charoughchi S; Liu JT; Berteau-Rainville M; Hase H; Askari MS; Bhagat S; Forgione P; Salzmann I; 37220083
CHEMBIOCHEM
6 Diverse Applications of Biomass-Derived 5-Hydroxymethylfurfural and Derivatives as Renewable Starting Materials Chacón-Huete F; Messina C; Cigana B; Forgione P; 35652539
CHEMBIOCHEM
7 Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al2O3 surface under ball-milling conditions Hernandez R RA; Burchell-Reyes K; Braga APCA; Lopez JK; Forgione P; 35424611
CHEMBIOCHEM
8 Characterization of a recently synthesized microtubule-targeting compound that disrupts mitotic spindle poles in human cells Jaunky DB; Larocque K; Husser MC; Liu JT; Forgione P; Piekny A; 34880347
BIOLOGY
9 Programmed Synthesis of Tetra-Aryl Thiophenes with Stepwise, Ester-Controlled Regioselectivity Messina C; Ottenwaelder X; Forgione P; 34506149
CHEMBIOCHEM
10 Design, structure-activity relationship study and biological evaluation of the thieno[3,2-c]isoquinoline scaffold as a potential anti-cancer agent Liu JT; Jaunky DB; Larocque K; Chen F; Mckibbon K; Sirouspour M; Taylor S; Shafeii A; Campbell D; Braga H; Piekny A; Forgione P; 34416378
BIOLOGY
11 Synthesis of 2,5-Diaryl Nonsymmetric Furans C6-Platform Chemicals via Catalytic Conversion of Biomass and the Formal Synthesis of Dantrolene. Chacón-Huete F, Lasso JD, Szavay P, Covone J, Forgione P 33253575
CHEMBIOCHEM
12 Approaching the Integer-Charge Transfer Regime in Molecularly Doped Oligothiophenes by Efficient Decarboxylative Cross-Coupling Liu JT; Hase H; Taylor S; Salzmann I; Forgione P; 31961982
CHEMBIOCHEM
13 Facile Aqueous-Phase Synthesis of an Ultrasmall Bismuth Nanocatalyst for the Reduction of 4-Nitrophenol. Liang Y, Manioudakis J, Macairan JR, Askari MS, Forgione P, Naccache R 31552336
CHEMBIOCHEM
14 Virtual screening, docking, and dynamics of potential new inhibitors of dihydrofolate reductase from Yersinia pestis. Bastos Lda C, de Souza FR, Guimarães AP, Sirouspour M, Cuya Guizado TR, Forgione P, Ramalho TC, França TC 26494420
CHEMISTRY
15 Analysis of Coxiela burnetti dihydrofolate reductase via in silico docking with inhibitors and molecular dynamics simulation. de Souza FR, Guimarães AP, Cuya T, de Freitas MP, Gonçalves ADS, Forgione P, Costa França TC 27726597
CHEMBIOCHEM
16 Investigating the selectivity of potential new inhibitors of dihydrofolate reductase from Yersinia pestis designed by molecular modeling. Bastos LDC, de Souza FR, Pereira Souza LM, Forgione P, Cuya T, de Alencastro RB, Pimentel AS, Celmar Costa França T 29542379
CHEMBIOCHEM

 

Title:Synthesis of 2,5-Diaryl Nonsymmetric Furans C6-Platform Chemicals via Catalytic Conversion of Biomass and the Formal Synthesis of Dantrolene.
Authors:Chacón-Huete F,  Lasso JD,  Szavay P,  Covone J,  Forgione P
Link:https://www.ncbi.nlm.nih.gov/pubmed/33253575
DOI:10.1021/acs.joc.0c02236
Publication:The Journal of organic chemistry
Keywords:
PMID:33253575 Category:J Org Chem Date Added:2020-12-01
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal QC H4B 1R6, Canada.
2 Centre in Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal QC H3A 2K6, Canada.

Description:

Synthesis of 2,5-Diaryl Nonsymmetric Furans C6-Platform Chemicals via Catalytic Conversion of Biomass and the Formal Synthesis of Dantrolene.

J Org Chem. 2020 Nov 30; :

Authors: Chacón-Huete F, Lasso JD, Szavay P, Covone J, Forgione P

Abstract

Biomass-derived commodity chemical 5-hydroxymethyl furfural is an underutilized C6-platform chemical derived from cellulose that is ideal to prepare next-generation value-added products. We have developed an efficient synthetic strategy to access 2,5-diaryl nonsymmetric furans from 5-hydroxymethyl furfural utilizing decarboxylative cross-couplings. A key finding was that the presence of the hydroxymethyl handle enhances the yields of the palladium-catalyzed decarboxylative cross-coupling reaction. The method provides access to a broad-range nonsymmetric 2,5-diaryl furans where each arene can be systematically introduced as required. Additionally, this green synthetic strategy was employed for a formal synthesis of the muscle relaxant Dantrolene in excellent yields.

PMID: 33253575 [PubMed - as supplied by publisher]




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