PERFORM Publications

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Title		Authors	PubMed ID
1	Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae.	Fossati E, Ekins A, Narcross L, Zhu Y, Falgueyret JP, Beaudoin GA, Facchini PJ, Martin VJ	24513861 BIOLOGY
2	Synthesis of Morphinan Alkaloids in Saccharomyces cerevisiae.	Fossati E, Narcross L, Ekins A, Falgueyret JP, Martin VJ	25905794 BIOLOGY
3	Microbial Factories for the Production of Benzylisoquinoline Alkaloids.	Narcross L, Fossati E, Bourgeois L, Dueber JE, Martin VJJ	26775900 BIOLOGY
4	Reconstituting Plant Secondary Metabolism in Saccharomyces cerevisiae for Production of High-Value Benzylisoquinoline Alkaloids.	Pyne ME, Narcross L, Fossati E, Bourgeois L, Burton E, Gold ND, Martin VJ	27417930 CSFG
5	Mining Enzyme Diversity of Transcriptome Libraries through DNA Synthesis for Benzylisoquinoline Alkaloid Pathway Optimization in Yeast.	Narcross L, Bourgeois L, Fossati E, Burton E, Martin VJ	27442619 BIOLOGY
6	A Combinatorial Approach To Study Cytochrome P450 Enzymes for De Novo Production of Steviol Glucosides in Baker's Yeast.	Gold ND, Fossati E, Hansen CC, DiFalco M, Douchin V, Martin VJJ	30474973 CSFG

Title:	Microbial Factories for the Production of Benzylisoquinoline Alkaloids.
Authors:	Narcross L, Fossati E, Bourgeois L, Dueber JE, Martin VJJ
Link:	https://www.ncbi.nlm.nih.gov/pubmed/26775900?dopt=Abstract
DOI:	10.1016/j.tibtech.2015.12.005
Publication:	Trends in biotechnology
Keywords:	aromatic amino acids; benzylisoquinoline alkaloids; biosecurity; dopamine; microbial synthesis; morphinans;
PMID:	26775900	Category:	Trends Biotechnol	Date Added:	2019-06-07
Dept Affiliation:	BIOLOGY 1 Department of Biology, Concordia University, Montréal, Québec H4B 1R6, Canada; Centre for Structural and Functional Genomics, Concordia University, Montréal, Québec H4B 1R6, Canada. 2 Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94704, USA. 3 Department of Biology, Concordia University, Montréal, Québec H4B 1R6, Canada; Centre for Structural and Functional Genomics, Concordia University, Montréal, Québec H4B 1R6, Canada. Electronic address: vincent.martin@concordia.ca.

Description:

Microbial Factories for the Production of Benzylisoquinoline Alkaloids.

Trends Biotechnol. 2016 Mar;34(3):228-241

Authors: Narcross L, Fossati E, Bourgeois L, Dueber JE, Martin VJJ

Abstract

Benzylisoquinoline alkaloids (BIAs) are a family of ~2500 alkaloids with both potential and realized pharmaceutical value, including most notably the opiates such as codeine and morphine. Only a few BIAs accumulate readily in plants, which limits the pharmaceutical potential of the family. Shifting BIA production to microbial sources could provide a scalable and flexible source of these compounds in the future. This review details the current status of microbial BIA synthesis and derivatization, including rapid developments in the past 6 months culminating in the synthesis of opioids from glucose in a microbial host.

PMID: 26775900 [PubMed - indexed for MEDLINE]

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