Keyword search (4,163 papers available)

"Gagnon JF" Authored Publications:

Title Authors PubMed ID
1 Increased brain cholinergic innervation in isolated REM sleep behaviour disorder from prodromal multiple system atrophy Wickens RH; Postuma RB; de Villers-Sidani É; Pelletier A; Blinder S; Gagnon JF; Soucy JP; Montplaisir J; Bedard MA; 37939636
PERFORM
2 PASS: A Multimodal Database of Physical Activity and Stress for Mobile Passive Body/ Brain-Computer Interface Research Parent M; Albuquerque I; Tiwari A; Cassani R; Gagnon JF; Lafond D; Tremblay S; Falk TH; 33363449
PERFORM
3 WAUC: A Multi-Modal Database for Mental Workload Assessment Under Physical Activity Albuquerque I; Tiwari A; Parent M; Cassani R; Gagnon JF; Lafond D; Tremblay S; Falk TH; 33335465
PERFORM
4 Behavioral and Psychological Symptoms that Predict Cognitive Decline or Impairment in Cognitively Normal Middle-Aged or Older Adults: a Meta-Analysis. Hudon C, Escudier F, De Roy J, Croteau J, Cross N, Dang-Vu TT, Zomahoun HTV, Grenier S, Gagnon JF, Parent A, Bruneau MA, Belleville S, Consortium for the Early Identification of Alzheimer’s Disease Quebec 32394109
HKAP
5 Chronic Neuroleptic-Induced Parkinsonism Examined with Positron Emission Tomography. Galoppin M, Berroir P, Soucy JP, Suzuki Y, Lavigne GJ, Gagnon JF, Montplaisir JY, Stip E, Blanchet PJ 32353194
PERFORM
6 Evidence of a Relation Between Hippocampal Volume, White Matter Hyperintensities, and Cognition in Subjective Cognitive Decline and Mild Cognitive Impairment Caillaud M; Hudon C; Boller B; Brambati S; Duchesne S; Lorrain D; Gagnon JF; Maltezos S; Mellah S; Phillips N; Belleville S; 31758692
CRDH
7 Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies Krohn L; Öztürk TN; Vanderperre B; Ouled Amar Bencheikh B; Ruskey JA; Laurent SB; Spiegelman D; Postuma RB; Arnulf I; Hu MTM; Dauvilliers Y; Högl B; Stefani A; Monaca CC; Plazzi G; Antelmi E; Ferini-Strambi L; Heidbreder A; Rudakou U; Cochen De Cock V; Young P; Wolf P; Oliva P; Zhang XK; Greenbaum L; Liong C; Gagnon JF; Desautels A; Hassin-Baer S; Montplaisir JY; Dupré N; Rouleau GA; Fon EA; Trempe JF; Lamoureux G; Alcalay RN; Gan-Or Z; 31658403
CERMM
8 Brain perfusion during rapid-eye-movement sleep successfully identifies amnestic mild cognitive impairment. Brayet P, Petit D, Baril AA, Gosselin N, Gagnon JF, Soucy JP, Gauthier S, Kergoat MJ, Carrier J, Rouleau I, Montplaisir J 28522082
PERFORM
9 Brain cholinergic alterations in idiopathic REM sleep behaviour disorder: a PET imaging study with 18F-FEOBV. Bedard MA, Aghourian M, Legault-Denis C, Postuma RB, Soucy JP, Gagnon JF, Pelletier A, Montplaisir J 31078078
PERFORM
10 Effects of exercise training on cognition in chronic obstructive pulmonary disease: A systematic review. Desveaux L, Harrison SL, Gagnon JF, Goldstein RS, Brooks D, Pepin V 29857994
HKAP

 

Title:Evidence of a Relation Between Hippocampal Volume, White Matter Hyperintensities, and Cognition in Subjective Cognitive Decline and Mild Cognitive Impairment
Authors:Caillaud MHudon CBoller BBrambati SDuchesne SLorrain DGagnon JFMaltezos SMellah SPhillips NBelleville S
Link:https://pubmed.ncbi.nlm.nih.gov/31758692/
DOI:10.1093/geronb/gbz120
Publication:The journals of gerontology. Series B, Psychological sciences and social sciences
Keywords:Alzheimer's diseaseBiomarkersNeuroimagingNeuropsychology
PMID:31758692 Category:J Gerontol B Psychol Sci Soc Sci Date Added:2019-11-24
Dept Affiliation: CRDH
1 Research Centre, Institut universitaire de gériatrie de Montréal, Québec, Canada.
2 Department of Psychology, Université de Montréal, Québec, Canada.
3 CERVO Brain Research Centre, Institut universitaire en santé mentale de Québec, Canada.
4 Department of Psychology, Université de Laval, Québec, Canada.
5 Departement of Psychology, Université du Québec à Trois-Rivières, Québec, Canada.
6 Department of Radiology, Université de Laval, Québec, Canada.
7 Research Centre, Centre de recherche sur le vieillissement de Sherbrooke, Québec, Canada.
8 Department of Psychology, Université de Sherbrooke, Québec, Canada.
9 Department of Psychology, Université du Québec à Montréal, Québec, Canada.
10 Department of Psychology, Centre for Research in Human Development (CRDH), Concordia University, Montreal, Québec, Canada.

Description:

Objective: The concepts of mild cognitive impairment (MCI) and subjective cognitive decline (SCD) have been proposed to identify individuals in the early stages of Alzheimer's disease (AD), or other neurodegenerative diseases. One approach to validate these concepts is to investigate the relationship between pathological brain markers and cognition in those individuals.

Method: We included 126 participants from the Consortium for the Early Identification of Alzheimer's disease-Quebec (CIMA-Q) cohort (67 SCD, 29 MCI, and 30 cognitively healthy controls [CH]). All participants underwent a complete cognitive assessment and structural magnetic resonance imaging. Group comparisons were done using cognitive data, and then correlated with hippocampal volumes and white matter hyperintensities (WMHs).

Results: Significant differences were found between participants with MCI and CH on episodic and executive tasks, but no differences were found when comparing SCD and CH. Scores on episodic memory tests correlated with hippocampal volumes in both MCI and SCD, whereas performance on executive tests correlated with WMH in all of our groups.

Discussion: As expected, the SCD group was shown to be cognitively healthy on tasks where MCI participants showed impairment. However, SCD's hippocampal volume related to episodic memory performances, and WMH to executive functions. Thus, SCD represents a valid research concept and should be used, alongside MCI, to better understand the preclinical/prodromal phase of AD.





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