Keyword search (4,164 papers available)

"Gervais NJ" Authored Publications:

Title Authors PubMed ID
1 Effects of early midlife ovarian removal on sleep: Polysomnography-measured cortical arousal, homeostatic drive, and spindle characteristics Brown A; Gervais NJ; Gravelsins L; O' Byrne J; Calvo N; Ramana S; Shao Z; Bernardini M; Jacobson M; Rajah MN; Einstein G; 39178647
HKAP
2 Modulatory effect of 17-β estradiol on performance of ovariectomized rats on the Shock-Probe test. Gervais NJ, Jacob S, Brake WG, Mumby DG 24768650
PSYCHOLOGY
3 Retrograde and anterograde memory following selective damage to the dorsolateral entorhinal cortex. Gervais NJ, Barrett-Bernstein M, Sutherland RJ, Mumby DG 25108197
PSYCHOLOGY
4 Attenuation of dendritic spine density in the perirhinal cortex following 17β-Estradiol replacement in the rat. Gervais NJ, Mumby DG, Brake WG 26104963
CSBN
5 Intra-perirhinal cortex administration of estradiol, but not an ERβ agonist, modulates object-recognition memory in ovariectomized rats. Gervais NJ, Hamel LM, Brake WG, Mumby DG 27321161
PSYCHOLOGY

 

Title:Attenuation of dendritic spine density in the perirhinal cortex following 17β-Estradiol replacement in the rat.
Authors:Gervais NJ,  Mumby DG,  Brake WG
Link:https://www.ncbi.nlm.nih.gov/pubmed/26104963?dopt=Abstract
Publication:
Keywords:
PMID:26104963 Category:Hippocampus Date Added:2019-05-31
Dept Affiliation: CSBN
1 Department of Psychology, Center for Studies in Behavioral Neurobiology (CSBN), Concordia University, Montreal, Quebec, Canada.

Description:

Attenuation of dendritic spine density in the perirhinal cortex following 17ß-Estradiol replacement in the rat.

Hippocampus. 2015 Nov;25(11):1212-6

Authors: Gervais NJ, Mumby DG, Brake WG

Abstract

Intraperirhinal cortex infusion of 17-ß estradiol (E2) impairs object-recognition memory. However, it is not currently known whether this hormone modulates synaptic plasticity in this structure. Most excitatory synapses in the central nervous system are located on dendritic spines, and elevated E2 levels influence the density of these spines in several brain areas. The goal of the present study was to determine whether differences in dendritic spine density in the perirhinal cortex are observed following high E2 replacement in ovariectomized rats. The density of total spines, and mushroom-shaped (i.e. mature) spines were compared between a high E2 replacement (10 µg/kg/day, s.c.) and a no replacement condition. The perirhinal cortex is subdivided into Broadmann's area 35 and 36 and so group comparisons were made within each sub-region separately. High E2 replacement resulted in lower density of mushroom-shaped spines in area 35 relative to no replacement. There was no effect of high E2 replacement on dendritic spine density in area 36. These findings are consistent with the idea that higher E2 levels reduce dendritic spine density in area 35, which may result from spine shrinkage, or reduced synapse formation. This study provides preliminary evidence for a mechanism through which E2 may impair object-recognition memory.

PMID: 26104963 [PubMed - indexed for MEDLINE]




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