Keyword search (4,164 papers available)

"Hopewell R" Authored Publications:

Title Authors PubMed ID
1 Associations between brain and cognitive resilience, tau load and extent in Alzheimer's disease Mitchell SW; Chan T; Trudel L; Hosseini SA; Macedo AC; Gonçalves MP; Rahmouni N; Hall BJ; Socualaya KMQ; Therriault J; Servaes S; Bezgin G; Zheng Y; Aumont E; Wang YT; Arias JF; Real APB; Jia WL; Hopewell R; Hsiao C; Soucy JP; Vitali P; Pascoal TA; Rosa-Neto P; 41512332
PERFORM
2 Alzheimer s Imaging Consortium Mitchell SW; Chan T; Trudel L; Hosseini SA; Macedo AC; Gonçalves MP; Rahmouni N; Hall BJ; Socualaya KMQ; Therriault J; Servaes S; Bezgin G; Zheng Y; Aumont E; Wang YT; Arias JF; Real APB; Jia WL; Hopewell R; Hsiao C; Soucy JP; Vitali P; Pascoal TA; Rosa-Neto P; 41433447
PERFORM
3 Development of "[11C]kits" for a fast, efficient and reliable production of carbon-11 labeled radiopharmaceuticals for Positron Emission Tomography. Jolly D, Hopewell R, Kovacevic M, Li QY, Soucy JP, Kostikov A 28038410
PERFORM

 

Title:Development of "[11C]kits" for a fast, efficient and reliable production of carbon-11 labeled radiopharmaceuticals for Positron Emission Tomography.
Authors:Jolly D,  Hopewell R,  Kovacevic M,  Li QY,  Soucy JP,  Kostikov A
Link:https://www.ncbi.nlm.nih.gov/pubmed/28038410?dopt=Abstract
DOI:10.1016/j.apradiso.2016.11.020
Publication:Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Keywords:Automated radiolabeling;  Carbon-11 radiotracers;  Kit-like production;  Positron Emission Tomography; 
PMID:28038410 Category:Appl Radiat Isot Date Added:2019-06-20
Dept Affiliation: PERFORM
1 Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4.
2 Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4; Concordia-PERFORM Centre, Concordia University, Montreal, Canada.

Description:

Development of "[11C]kits" for a fast, efficient and reliable production of carbon-11 labeled radiopharmaceuticals for Positron Emission Tomography.

Appl Radiat Isot. 2017 Mar;121:76-81

Authors: Jolly D, Hopewell R, Kovacevic M, Li QY, Soucy JP, Kostikov A

Abstract

Translation of carbon-11 labeled PET tracers to clinical settings is currently impeded by the technical difficulties associated with [11C]CO2 conversion into the highly reactive methylating agents [11C]CH3I and [11C]CH3OTf using automated modules relying on stationary valves. Here we describe development of the first in its kind "[11C]kit" for production of carbon-11 radiotracer using disposable manifolds. This method proved to be very reliable and allows for consecutive production of PET tracers with minimal intervals between the syntheses.

PMID: 28038410 [PubMed - indexed for MEDLINE]




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