Keyword search (4,164 papers available)

"Iordanova MD" Authored Publications:

Title Authors PubMed ID
1 Different behavioral measures of conditioned magazine activity can tell different stories about brain function Volz S; Loewinger G; Marquez I; Fevola S; Kang M; Reverte I; Krishnan A; Gardner MPH; Iordanova MD; Esber GR; 41922165
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2 Reduction in reward-driven behaviour depends on the basolateral but not central nucleus of the amygdala in female rats Lay BPP; Esber GR; Iordanova MD; 40925675
PSYCHOLOGY
3 Disentangling prediction error and value in a formal test of dopamine s role in reinforcement learning Usypchuk AA; Maes EJP; Lozzi M; Avramidis DK; Schoenbaum G; Esber GR; Gardner MPH; Iordanova MD; 40738112
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4 The Rescorla-Wagner Model: It Is Not What You Think It Is Esber G; Schoenbaum G; Iordanova MD; 39805526
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5 OFC neurons do not represent the negative value of a conditioned inhibitor Esber GR; Usypchuk A; Saini S; Deroche M; Iordanova MD; Schoenbaum G; 38042330
CONCORDIA
6 Parvalbumin interneuron loss mediates repeated anesthesia-induced memory deficits in mice Roque PS; Thörn Perez C; Hooshmandi M; Wong C; Eslamizade MJ; Heshmati S; Brown N; Sharma V; Lister KC; Goyon VM; Neagu-Lund L; Shen C; Daccache N; Sato H; Sato T; Mogil JS; Nader K; Gkogkas CG; Iordanova MD; Prager-Khoutorsky M; McBride HM; Lacaille JC; Wykes L; Schricker T; Khoutorsky A; 36394958
PSYCHOLOGY
7 The Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala During the First Extinction Episode Has Persistent Effects on Extinction Expression Lay BPP; Koya E; Hope BT; Esber GR; Iordanova MD; 36336498
PSYCHOLOGY
8 Correction to: Persistent disruption of overexpectation learning after inactivation of the lateral orbitofrontal cortex in male rats Lay BPP; Choudhury R; Esber GR; Iordanova MD; 36006415
PSYCHOLOGY
9 Experimental chambers Persistent disruption of overexpectation learning after inactivation of the lateral orbitofrontal cortex in male rats Lay BPP; Choudhury R; Esber GR; Iordanova MD; 35932299
PSYCHOLOGY
10 Understanding Associative Learning Through Higher-Order Conditioning Gostolupce D; Lay BPP; Maes EJP; Iordanova MD; 35517574
PSYCHOLOGY
11 Agency rescues competition for credit assignment among predictive cues from adverse learning conditions Kang M; Reverte I; Volz S; Kaufman K; Fevola S; Matarazzo A; Alhazmi FH; Marquez I; Iordanova MD; Esber GR; 34376741
PSYCHOLOGY
12 Mechanisms of higher-order learning in the amygdala Gostolupce D; Iordanova MD; Lay BPP; 34197867
PSYCHOLOGY
13 Threat perception: Fear and the retrorubal field Bradfield LA; Iordanova MD; 34033766
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14 Neural substrates of appetitive and aversive prediction error. Iordanova MD, Yau JO, McDannald MA, Corbit LH 33453307
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15 Adaptive behaviour under conflict: deconstructing extinction, reversal, and active avoidance learning. Manning EE, Bradfield LA, Iordanova MD 33035525
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16 Different methods of fear reduction are supported by distinct cortical substrates. Lay BP, Pitaru AA, Boulianne N, Esber GR, Iordanova MD 32589138
PSYCHOLOGY
17 A self-initiated cue-reward learning procedure for neural recording in rodents. Reverte I, Volz S, Alhazmi FH, Kang M, Kaufman K, Chan S, Jou C, Iordanova MD, Esber GR 32135212
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18 Causal evidence supporting the proposal that dopamine transients function as temporal difference prediction errors. Maes EJP, Sharpe MJ, Usypchuk AA, Lozzi M, Chang CY, Gardner MPH, Schoenbaum G, Iordanova MD 31959935
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19 Neural correlates of two different types of extinction learning in the amygdala central nucleus. Iordanova MD, Deroche ML, Esber GR, Schoenbaum G 27531638
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20 Dopamine Signaling Is Critical for Supporting Cue-Driven Behavioral Control. Iordanova MD 31103706
PSYCHOLOGY
21 Thought control with the dopamine transient. Iordanova MD 30338459
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22 Dissociation of Appetitive Overexpectation and Extinction in the Infralimic Cortex. Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD 30371757
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23 Corrigendum: Dissociation of Appetitive Overexpectation and Extinction in the Infralimbic Cortex. Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD 30590441
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24 The serial blocking effect: a testbed for the neural mechanisms of temporal-difference learning. Mahmud A; Petrov P; Esber GR; Iordanova MD; 30979910
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Title:Parvalbumin interneuron loss mediates repeated anesthesia-induced memory deficits in mice
Authors:Roque PS,  Thörn Perez C,  Hooshmandi M,  Wong C,  Eslamizade MJ,  Heshmati S,  Brown N,  Sharma V,  Lister KC,  Goyon VM,  Neagu-Lund L,  Shen C,  Daccache N,  Sato H,  Sato T,  Mogil JS,  Nader K,  Gkogkas CG,  Iordanova MD,  Prager-Khoutorsky M,  McBride HM,  Lacaille JC,  Wykes L,  Schricker T,  Khoutorsky A
Link:https://pubmed.ncbi.nlm.nih.gov/36394958/
DOI:10.1172/JCI159344
Publication:The Journal of clinical investigation
Keywords:Apoptosis;  Memory;  Neuroscience; 
PMID:36394958 Category: Date Added:2022-11-17
Dept Affiliation: PSYCHOLOGY
1 Department of Anesthesia and.
2 School of Human Nutrition, McGill University, Montreal, Canada.
3 Department of Neurosciences, Center for Interdisciplinary Research on Brain and Learning (CIRCA) and Research Group on Neural Signaling and Circuitry (GRSNC), Université de Montréal, Montreal, Canada.
4 Department of Biochemistry, McGill University, Montreal, Canada.
5 Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
6 Montreal Neurological Institute.
7 Department of Psychology, Faculty of Science, and.
8 Alan Edwards Centre for Research on Pain, McGill University, Montreal, Canada.
9 Biomedical Research Institute, Foundation for Research and Technology-Hellas, University Campus, Ioannina, Greece.
10 Department of Psychology/Centre for Studies in Behavioural Neurobiology, Concordia University, Montreal, Canada.
11 Department of Physiology and.
12 Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, Canada.

Description:

Repeated or prolonged, but not short-term, general anesthesia during the early postnatal period causes long-lasting impairments in memory formation in various species. The mechanisms underlying long-lasting impairment in cognitive function are poorly understood. Here, we show that repeated general anesthesia in postnatal mice induces preferential apoptosis and subsequent loss of parvalbumin-positive inhibitory interneurons in the hippocampus. Each parvalbumin interneuron controls the activity of multiple pyramidal excitatory neurons, thereby regulating neuronal circuits and memory consolidation. Preventing the loss of parvalbumin neurons by deleting a proapoptotic protein, mitochondrial anchored protein ligase (MAPL), selectively in parvalbumin neurons rescued anesthesia-induced deficits in pyramidal cell inhibition and hippocampus-dependent long-term memory. Conversely, partial depletion of parvalbumin neurons in neonates was sufficient to engender long-lasting memory impairment. Thus, loss of parvalbumin interneurons in postnatal mice following repeated general anesthesia critically contributes to memory deficits in adulthood.





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