Keyword search (4,164 papers available)

"Jiang Y" Authored Publications:

Title Authors PubMed ID
1 Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles antifungal activities Li W; Whiteway M; Hang S; Yu J; Lu H; Jiang Y; 40707518
BIOLOGY
2 Adaptive finite-time synchronized control of multi-robotic fiber placement system with model uncertainties and disturbances Zhang R; Wang Y; Xie W; Li P; Tan H; Jiang Y; 40461302
ENCS
3 Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in Candida Albicans Zhen C; Wang L; Feng Y; Whiteway M; Hang S; Yu J; Lu H; Jiang Y; 38995235
BIOLOGY
4 Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species Li W; Feng Y; Feng Z; Wang L; Whiteway M; Lu H; Jiang Y; 38929106
BIOLOGY
5 Understanding Fluconazole Tolerance in Candida albicans: Implications for Effective Treatment of Candidiasis and Combating Invasive Fungal Infections Feng Y; Lu H; Whiteway M; Jiang Y; 37918789
BIOLOGY
6 Candidiasis: from cutaneous to systemic, new perspectives of potential targets and therapeutic strategies Lu H; Hong T; Jiang Y; Whiteway M; Zhang S; 37307922
BIOLOGY
7 A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols Lu H; Li W; Whiteway M; Wang H; Zhu S; Ji Z; Feng Y; Yan L; Fang T; Li L; Ni T; Zhang X; Lv Q; Ding Z; Qiu L; Zhang D; Jiang Y; 36475771
BIOLOGY
8 Calcium-calcineurin signaling pathway in Candida albicans: A potential drug target Li W; Shrivastava M; Lu H; Jiang Y; 33989979
BIOLOGY
9 Candida albicans targets that potentially synergize with fluconazole. Lu H, Shrivastava M, Whiteway M, Jiang Y 33587857
BIOLOGY
10 Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits. Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG 32610139
PERFORM

 

Title:Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.
Authors:Tamming RJDumeaux VJiang YShafiq SLanglois LEllegood JQiu LRLerch JPBérubé NG
Link:https://www.ncbi.nlm.nih.gov/pubmed/32610139?dopt=Abstract
DOI:10.1016/j.celrep.2020.107838
Publication:Cell reports
Keywords:ATRXH3K27me3chromatinhippocampusintellectual disabilitylong-term spatial memorymiR-137presynaptic vesiclessex differencessynapse
PMID:32610139 Category:Cell Rep Date Added:2020-07-02
Dept Affiliation: PERFORM
1 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Biochemistry, Western University, London, ON, Canada.
2 Department of Paediatrics, Western University, London, ON, Canada; PERFORM Centre, Concordia University, Montreal, QC, Canada.
3 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada.
4 Children's Health Research Institute, London, ON, Canada; Department of Paediatrics, Western University, London, ON, Canada; Department of Anatomy & Cell Biology, Western University, London, ON, Canada.
5 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Anatomy & Cell Biology, Western University, London, ON, Canada.
6 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada.
7 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada; Wellcome Centre for Integrative Neuroimaging, The University of Oxford, Oxford, UK.
8 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, The University of Toronto, Toronto, ON, Canada; Wellcome Centre for Integrative Neuroimaging, The University of Oxford, Oxford, UK.
9 Children's Health Research Institute, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Paediatrics, Western University, London, ON, Canada; Department of Anatomy & Cell Biology, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada. Electronic address: nberube@uwo.ca.

Description:

Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.

Cell Rep. 2020 Jun 30;31(13):107838

Authors: Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Abstract

ATRX gene mutations have been identified in syndromic and non-syndromic intellectual disabilities in humans. ATRX is known to maintain genomic stability in neuroprogenitor cells, but its function in differentiated neurons and memory processes remains largely unresolved. Here, we show that the deletion of neuronal Atrx in mice leads to distinct hippocampal structural defects, fewer presynaptic vesicles, and an enlarged postsynaptic area at CA1 apical dendrite-axon junctions. We identify male-specific impairments in long-term contextual memory and in synaptic gene expression, linked to altered miR-137 levels. We show that ATRX directly binds to the miR-137 locus and that the enrichment of the suppressive histone mark H3K27me3 is significantly reduced upon the loss of ATRX. We conclude that the ablation of ATRX in excitatory forebrain neurons leads to sexually dimorphic effects on miR-137 expression and on spatial memory, identifying a potential therapeutic target for neurological defects caused by ATRX dysfunction.

PMID: 32610139 [PubMed - as supplied by publisher]





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