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PubMed Publications| Keyword search (4,163 papers available) |  |
"Juneau G" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Controlling Temozolomide Efficacy by Light-Dependent Inhibition of O sup 6 /sup ‑Methylguanine DNA Methyltransferase | Lopez-Miranda IR; Sim JI; Juneau G; Wilds CJ; Beharry AA; | 41531960 CHEMBIOCHEM |
| 2 | A chloromethyl-triazole fluorescent chemosensor for O6-methylguanine DNA methyltransferase | Ayan S; Rotaru AM; Kaye EG; Juneau G; Das S; Wilds CJ; Beharry AA; | 38502038 CHEMBIOCHEM |
| 3 | Beyond ribose and phosphate: Selected nucleic acid modifications for structure-function investigations and therapeutic applications | Liczner C; Duke K; Juneau G; Egli M; Wilds CJ; | 33981365 CHEMBIOCHEM |
| Title: | Beyond ribose and phosphate: Selected nucleic acid modifications for structure-function investigations and therapeutic applications | ||||
| Authors: | Liczner C, Duke K, Juneau G, Egli M, Wilds CJ | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/33981365/ | ||||
| DOI: | 10.3762/bjoc.17.76 | ||||
| Publication: | Beilstein journal of organic chemistry | ||||
| Keywords: | antisense; chemically modified oligonucleotides; crystallography; siRNA; structure; | ||||
| PMID: | 33981365 | Category: | Date Added: | 2021-05-19 | |
| Dept Affiliation: |
CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University, Montréal, Québec H4B 1R6, Canada. 2 Department of Biochemistry, Vanderbilt Institute of Chemical Biology, and Center for Structural Biology, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, United States. |
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Description: |
Over the past 25 years, the acceleration of achievements in the development of oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the market for the treatment of various diseases. Oligonucleotides with alterations to their scaffold, prepared with modified nucleosides and solid-phase synthesis, have yielded molecules with interesting biophysical properties that bind to their targets and are tolerated by the cellular machinery to elicit a therapeutic outcome. Structural techniques, such as crystallography, have provided insights to rationalize numerous properties including binding affinity, nuclease stability, and trends observed in the gene silencing. In this review, we discuss the chemistry, biophysical, and structural properties of a number of chemically modified oligonucleotides that have been explored for gene silencing. |
