PERFORM Publications

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Title		Authors	PubMed ID
1	The Smart in Smart Cities: A Framework for Image Classification Using Deep Learning	Al-Qudah R; Khamayseh Y; Aldwairi M; Khan S;	35746171 ENCS
2	Is subthreshold depression in adolescence clinically relevant?	Noyes BK; Munoz DP; Khalid-Khan S; Brietzke E; Booij L;	35429521 PSYCHOLOGY
3	Biallelic variants in TRAPPC10 cause a microcephalic TRAPPopathy disorder in humans and mice	Rawlins LE; Almousa H; Khan S; Collins SC; Milev MP; Leslie J; Saint-Dic D; Khan V; Hincapie AM; Day JO; McGavin L; Rowley C; Harlalka GV; Vancollie VE; Ahmad W; Lelliott CJ; Gul A; Yalcin B; Crosby AH; Sacher M; Baple EL;	35298461 BIOLOGY
4	Maturation of temporal saccade prediction from childhood to adulthood: predictive saccades, reduced pupil size and blink synchronization	Calancie OG; Brien DC; Huang J; Coe BC; Booij L; Khalid-Khan S; Munoz DP;	34759032 PSYCHOLOGY
5	Reductions of Anxiety Symptoms, State Anxiety, and Anxious Arousal in Youth Playing the Videogame MindLight Compared to Online Cognitive Behavioral Therapy	Tsui TYL; DeFrance K; Khalid-Khan S; Granic I; Hollenstein T;	34403591 PSYCHOLOGY
6	Methodological and clinical challenges associated with biomarkers for psychiatric disease: A scoping review.	Kirkpatrick RH; Munoz DP; Khalid-Khan S; Booij L;	33221025 PSYCHOLOGY
7	DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents.	Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L	32479312 PSYCHOLOGY
8	Are biophenotyes the key to select antinflammatory-responsive individuals with major depression?	Brietzke E, Booij L, Wieck A, Soares CN, Roberts N, Khalid-Khan S	31476416 PSYCHOLOGY
9	Eating disorders and substance use in adolescents: How substance users differ from nonsubstance users in an outpatient eating disorders treatment clinic.	Kirkpatrick R, Booij L, Vance A, Marshall B, Kanellos-Sutton M, Marchand P, Khalid-Khan S	30638270 PSYCHOLOGY
10	Use of routinely available clinical, nutritional, and functional criteria to classify cachexia in advanced cancer patients.	Vigano AAL, Morais JA, Ciutto L, Rosenthall L, di Tomasso J, Khan S, Olders H, Borod M, Kilgour RD	27793524 HKAP
11	Hypertension management research priorities from patients, caregivers, and healthcare providers: A report from the Hypertension Canada Priority Setting Partnership Group.	Khan N, Bacon SL, Khan S, Perlmutter S, Gerlinsky C, Dermer M, Johnson L, Alves F, McLean D, Laupacis A, Pui M, Berg A, Flowitt F, Hypertension Canada Priority Setting Partnership Group	28944609 HKAP

Title:	DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents.
Authors:	Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L
Link:	https://www.ncbi.nlm.nih.gov/pubmed/32479312?dopt=Abstract
DOI:	10.1016/j.jad.2020.03.062
Publication:	Journal of affective disorders
Keywords:	Adolescent depression; Brain structure; DNA methylation; Epigenetics; Functional connectivity;
PMID:	32479312	Category:	J Affect Disord	Date Added:	2020-06-02
Dept Affiliation:	PSYCHOLOGY 1 Department of Psychology, Concordia University, Montreal, Canada; CHU Sainte-Justine Hospital Research Centre, University of Montreal, Montreal, Canada; Department of Psychology, Queen's University, Kingston, Canada. 2 Department of Psychology, Queen's University, Kingston, Canada. 3 Department of Psychology, Concordia University, Montreal, Canada. 4 Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany. 5 Department of Psychiatry, Trinity College School of Medicine and Trinity College Institute of Neuroscience, Dublin, Ireland. 6 Department of Psychology, Concordia University, Montreal, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada; Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary. 7 Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada. 8 Department of Psychiatry, Division of Child Psychiatry, Hotel Dieu Hospital, Queen's University, Kingston, Canada. 9 Department of Psychology, Concordia University, Montreal, Canada; CHU Sainte-Justine Hospital Research Centre, University of Montreal, Montreal, Canada; Department of Psychology, Queen's University, Kingston, Canada. Electronic address: linda.booij@concordia.ca.

Description:

DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents.

J Affect Disord. 2020 Jun 15;271:160-168

Authors: Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L

Abstract

BACKGROUND: Studies in adult depressed patients have indicated that altered DNA methylation patterns at genes related to serotonin and HPA axis functioning (e.g., SLC6A4, FKBP5) are associated with changes in frontolimbic functional connectivity and structure. Here, we examined whether these associations can be generalized to adolescents.

METHODS: 25 adolescents with depression (Mean age = 15.72 ± 0.94 SD; 20 girls) and 20 healthy controls (Mean age = 16.05 ± 1.5 SD; 16 girls) underwent a functional and structural magnetic resonance imaging protocol, which included a resting-state assessment and measures of brain morphometry. DNA was obtained from saliva. Levels of SLC6A4 and FKBP5 methylation were determined using pyrosequencing.

RESULTS: SLC6A4 methylation was linked to amygdala-frontal operculum resting-state functional connectivity (rs-FC), regardless of diagnosis, and was differentially associated with inferior orbitofrontal gyrus (IFOG) gray matter (GM) volume in adolescents with depression and controls. Replicating and extending previous findings in adults, FKBP5 methylation was associated with IFOG GM volume in depressed and healthy adolescents, as well as orbitofrontal cortex (OFC)-rostral prefrontal cortex (RPFC) connectivity in healthy adolescents only.

LIMITATIONS: Effects of medication use or genotype cannot be ruled out. Further, the relatively small sample size and predominately female sample may limit generalizability.

CONCLUSIONS: These findings suggest that previously observed associations between SLC6A4 and FKBP5 methylation and frontolimbic processes in adult depressed patients can be in part generalized to adolescent patients. Further, findings suggest that measuring peripheral methylation at these genes deserves further attention as potential markers of typical and atypical development.

PMID: 32479312 [PubMed - as supplied by publisher]

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