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PubMed Publications| Keyword search (4,163 papers available) |  |
"Kumar R" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Developing and Sustaining Dementia Capable Communities: An Analysis of the Current Evidence | Biglieri S; Ahmed N; Main S; Tupling OL; Vijayakumar R; Boger J; Daum C; Dupuis S; Koch M; Liu L; Lopez K; Mann J; Martin M; McAiney C; Nasir HJ; Nasir N; Pearce B; Weldrick R; Vanderlinden K; Middleton L; | 41432943 ENCS |
| 2 | Interrogation of Bacillus anthracis SrtA active site loop forming open/close lid conformations through extensive MD simulations for understanding binding selectivity of SrtA inhibitors | Selvaraj C; Selvaraj G; Mohamed Ismail R; Vijayakumar R; Baazeem A; Wei DQ; Singh SK; | 34220215 BIOLOGY |
| 3 | Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography-High-Resolution Mass Spectrometry | Slobodchikova I; Sivakumar R; Rahman MS; Vuckovic D; | 31344861 CBAMS |
| 4 | Tuning of Morphology and Stability of Gold Nanostars Through pH Adjustment. | Kumar R, Badilescu S, Packirisamy M | 30913757 ENCS |
| 5 | Directing the Viedma ripening of ethylenediammonium sulfate using "Tailor-made" chiral additives. | Nguyen TP, Cheung PS, Werber L, Gagnon J, Sivakumar R, Lennox C, Sossin A, Mastai Y, Cuccia LA | 27722259 CHEMBIOCHEM |
| Title: | Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography-High-Resolution Mass Spectrometry | ||||
| Authors: | Slobodchikova I, Sivakumar R, Rahman MS, Vuckovic D | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/31344861/ | ||||
| DOI: | 10.3390/toxins11080433 | ||||
| Publication: | Toxins | ||||
| Keywords: | biomonitoring; glucuronidation; high-resolution mass spectrometry (HRMS); human; metabolism; microsomal incubation; mycotoxins; | ||||
| PMID: | 31344861 | Category: | Toxins (Basel) | Date Added: | 2019-08-07 |
| Dept Affiliation: |
CBAMS
1 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. 2 Centre for Biological Applications of Mass Spectrometry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. 3 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. dajana.vuckovic@concordia.ca. 4 Centre for Biological Applications of Mass Spectrometry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. dajana.vuckovic@concordia.ca. |
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Description: |
Routine mycotoxin biomonitoring methods do not include many mycotoxin phase I and phase II metabolites, which may significantly underestimate mycotoxin exposure especially for heavily metabolized mycotoxins. Additional research efforts are also needed to measure metabolites in vivo after exposure and to establish which mycotoxin metabolites should be prioritized for the inclusion during large-scale biomonitoring efforts. The objective of this study was to perform human in vitro microsomal incubations of 17 mycotoxins and systematically characterize all resulting metabolites using liquid chromatography-high-resolution mass spectrometry (LC-HRMS). The results obtained were then used to build a comprehensive LC-MS library and expand a validated 17-mycotoxin method for exposure monitoring to screening of additional 188 metabolites, including 100 metabolites reported for the first time. The final method represents one of the most comprehensive LC-HRMS methods for mycotoxin biomonitoring or metabolism/fate studies. |
