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PubMed Publications| Keyword search (4,163 papers available) |  |
"Kuzmin E" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | PARPAL: PARalog Protein Redistribution using Abundance and Localization in Yeast Database | Greco BM; Zapata G; Dandage R; Papkov M; Pereira V; Lefebvre F; Bourque G; Parts L; Kuzmin E; | 40580499 BIOLOGY |
| 2 | Single-cell imaging of protein dynamics of paralogs reveals sources of gene retention | Dandage R; Papkov M; Greco BM; Pereira V; Fishman D; Friesen H; Wang K; Styles EB; Kraus O; Grys B; Zapata G; Lefebvre F; Bourque G; Boone C; Andrews BJ; Parts L; Kuzmin E; | 40585364 BIOLOGY |
| 3 | Benchmarking macaque brain gene expression for horizontal and vertical translation | Luppi AI; Liu ZQ; Hansen JY; Cofre R; Niu M; Kuzmin E; Froudist-Walsh S; Palomero-Gallagher N; Misic B; | 40020056 BIOLOGY |
| 4 | Dynamics of karyotype evolution | Kuzmin E; Baker TM; Van Loo P; Glass L; | 38717409 CSFG |
| 5 | Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring | Kuzmin E; Baker TM; Lesluyes T; Monlong J; Abe KT; Coelho PP; Schwartz M; Del Corpo J; Zou D; Morin G; Pacis A; Yang Y; Martinez C; Barber J; Kuasne H; Li R; Bourgey M; Fortier AM; Davison PG; Omeroglu A; Guiot MC; Morris Q; Kleinman CL; Huang S; Gingras AC; Ragoussis J; Bourque G; Van Loo P; Park M; | 38517886 BIOLOGY |
| 6 | Trans-regulatory variant network contributes to missing heritability | Pereira V; Kuzmin E; | 38216282 BIOLOGY |
| 7 | Single-cell imaging of protein dynamics of paralogs reveals mechanisms of gene retention | Dandage R; Papkov M; Greco BM; Fishman D; Friesen H; Wang K; Styles E; Kraus O; Grys B; Boone C; Andrews B; Parts L; Kuzmin E; | 38045359 BIOLOGY |
| 8 | Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain | Hansen JY; Markello RD; Tuominen L; Nørgaard M; Kuzmin E; Palomero-Gallagher N; Dagher A; Misic B; | 36209794 CSBN |
| Title: | Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain | ||||
| Authors: | Hansen JY, Markello RD, Tuominen L, Nørgaard M, Kuzmin E, Palomero-Gallagher N, Dagher A, Misic B | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/36209794/ | ||||
| DOI: | 10.1016/j.neuroimage.2022.119671 | ||||
| Publication: | NeuroImage | ||||
| Keywords: | |||||
| PMID: | 36209794 | Category: | Date Added: | 2022-10-10 | |
| Dept Affiliation: |
CSBN
1 McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, Canada. Electronic address: justine.hansen@mail.mcgill.ca. 2 McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, Canada. 3 Department of Psychiatry, The Royal's Institute of Mental Health Research, University of Ottawa, ON, Canada. 4 Neurobiology Research Unit & CIMBI, Copenhagen University Hospital, Copenhagen, Denmark; Center for Reproducible Neuroscience, Department of Psychology, Stanford University, Stanford, California, USA. 5 Department of Biology, Centre for Applied Synthetic Biology, Concordia University, Montréal, Canada; Department of Human Genetics, Rosalind & Morris Goodman Cancer Institute, McGill University, Montréal, Canada. 6 Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH, Aachen, Germany; C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. 7 McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, Canada. Electronic address: bratislav.misic@mcgill.ca. |
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Description: |
Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter receptors and transporters play a key role in shaping brain function. Due to the lack of comprehensive neurotransmitter receptor/transporter density datasets, microarray gene expression measuring mRNA transcripts is often used as a proxy for receptor densities. In the present report, we comprehensively test the spatial correlation between gene expression and protein density for a total of 27 neurotransmitter receptors, receptor binding-sites, and transporters across 9 different neurotransmitter systems, using both PET and autoradiography radioligand-based imaging modalities. We find poor spatial correspondences between gene expression and density for all neurotransmitter receptors and transporters except four single-protein metabotropic receptors (5-HT1A, CB1, D2, and MOR). These expression-density associations are related to gene differential stability and can vary between cortical and subcortical structures. Altogether, we recommend using direct measures of receptor and transporter density when relating neurotransmitter systems to brain structure and function. |
