Keyword search (4,164 papers available)

"Kwan DH" Authored Publications:

Title Authors PubMed ID
1 Functional and structural characterization of an IclR family transcription factor for the development of dicarboxylic acid biosensors Pham C; Nasr MA; Skarina T; Di Leo R; Kwan DH; Martin VJJ; Stogios PJ; Mahadevan R; Savchenko A; 38696354
BIOLOGY
2 Divergent directed evolution of a TetR-type repressor towards aromatic molecules Nasr MA; Martin VJJ; Kwan DH; 37377432
BIOLOGY
3 A "biphasic glycosyltransferase high-throughput screen" identifies novel anthraquinone glycosides in the diversification of phenolic natural products Mohideen FI; Kwan DH; 36682498
CHEMBIOCHEM
4 Engineering the Enzyme Toolbox to Tailor Glycosylation in Small Molecule Natural Products and Protein Biologics Ouadhi S; López DMV; Mohideen FI; Kwan DH; 36444941
ENCS
5 A Versatile Transcription Factor Biosensor System Responsive to Multiple Aromatic and Indole Inducers Nasr MA; Timmins LR; Martin VJJ; Kwan DH; 35316041
CHEMBIOCHEM
6 In Vitro Reconstitution of the dTDP-l-Daunosamine Biosynthetic Pathway Provides Insights into Anthracycline Glycosylation Mohideen FI; Nguyen LH; Richard JD; Ouadhi S; Kwan DH; 34751552
CHEMBIOCHEM
7 Resources and Methods for Engineering "Designer" Glycan-Binding Proteins. Warkentin R, Kwan DH 33450899
CHEMBIOCHEM
8 Enzymatic Synthesis of a Fluorogenic Reporter Substrate and the Development of a High-Throughput Assay for Fucosyltransferase VIII Provide a Toolkit to Probe and Inhibit Core Fucosylation. Soroko M, Kwan DH 32441090
CHEMBIOCHEM
9 Structure-Guided Directed Evolution of Glycosidases: A Case Study in Engineering a Blood Group Antigen-Cleaving Enzyme. Kwan DH 28935105
CSFG

 

Title:Resources and Methods for Engineering "Designer" Glycan-Binding Proteins.
Authors:Warkentin R,  Kwan DH
Link:https://www.ncbi.nlm.nih.gov/pubmed/33450899
DOI:10.3390/molecules26020380
Publication:Molecules (Basel, Switzerland)
Keywords:carbohydrates;  directed evolution;  glycan immobilization;  glycan-binding protein;  glycans;  glycobiology;  lectins;  protein engineering; 
PMID:33450899 Category:Molecules Date Added:2021-01-17
Dept Affiliation: CHEMBIOCHEM
1 Department of Biology, Centre for Applied Synthetic Biology, and Centre for Structural and Functional Genomics, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada.
2 PROTEO, Quebec Network for Research on Protein Function, Structure, and Engineering, Quebec City, QC G1V 0A6, Canada.
3 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada.

Description:

Resources and Methods for Engineering "Designer" Glycan-Binding Proteins.

Molecules. 2021 Jan 13; 26(2):

Authors: Warkentin R, Kwan DH

Abstract

This review provides information on available methods for engineering glycan-binding proteins (GBP). Glycans are involved in a variety of physiological functions and are found in all domains of life and viruses. Due to their wide range of functions, GBPs have been developed with diagnostic, therapeutic, and biotechnological applications. The development of GBPs has traditionally been hindered by a lack of available glycan targets and sensitive and selective protein scaffolds; however, recent advances in glycobiology have largely overcome these challenges. Here we provide information on how to approach the design of novel "designer" GBPs, starting from the protein scaffold to the mutagenesis methods, selection, and characterization of the GBPs.

PMID: 33450899 [PubMed - as supplied by publisher]




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