Keyword search (4,163 papers available)

"Lafferty CK" Authored Publications:

Title Authors PubMed ID
1 All-optical approaches to studying psychiatric disease Lafferty CK; Christinck TD; Britt JP; 34314828
CSBN
2 Off-Target Influences of Arch-Mediated Axon Terminal Inhibition on Network Activity and Behavior. Lafferty CK, Britt JP 32269514
CSBN
3 Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking. Lafferty CK, Yang AK, Mendoza JA, Britt JP 32187545
CSBN
4 Cannabis Exposure Enhances Subcortical Control of Nucleus Accumbens Activity. Lafferty CK; Britt JP; 32164914
CSBN
5 Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability. Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP 31699294
CSBN
6 Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value. Mendoza JA, Lafferty CK, Yang AK, Britt JP 31693885
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7 Coordinated Reductions in Excitatory Input to the Nucleus Accumbens Underlie Food Consumption. Reed SJ, Lafferty CK, Mendoza JA, Yang AK, Davidson TJ, Grosenick L, Deisseroth K, Britt JP 30146308
PSYCHOLOGY

 

Title:Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking.
Authors:Lafferty CK,  Yang AK,  Mendoza JA,  Britt JP
Link:https://www.ncbi.nlm.nih.gov/pubmed/32187545?dopt=Abstract
DOI:10.1016/j.celrep.2020.02.095
Publication:Cell reports
Keywords:basolateral amygdala;  behavioral inhibition;  direct pathway;  fiber photometry;  indirect pathway;  nucleus accumbens;  optogenetics;  paraventricular nucleus of the thalamus;  place preference;  self-stimulation; 
PMID:32187545 Category:Cell Rep Date Added:2020-03-19
Dept Affiliation: CSBN
1 Department of Psychology, McGill University, Montreal, QC, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.
2 Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.
3 Department of Psychology, McGill University, Montreal, QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada. Electronic address: jonathan.britt@mcgill.ca.

Description:

Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking.

Cell Rep. 2020 Mar 17;30(11):3729-3742.e3

Authors: Lafferty CK, Yang AK, Mendoza JA, Britt JP

Abstract

The nucleus accumbens (NAc) contributes to behavioral inhibition and compulsions, but circuit mechanisms are unclear. Recent evidence suggests that amygdala and thalamic inputs exert opposing control over behavior, much like direct and indirect pathway output neurons. Accordingly, opponent processes between these NAc inputs or cell types may underlie efficient reward seeking. We assess the contributions of these circuit elements to mouse operant behavior during recurring conditions when reward is and is not available. Although direct pathway stimulation is rewarding and indirect pathway stimulation aversive, the activity of both cell types is elevated during periods of behavioral suppression, and the inhibition of either cell-type selectively increases unproductive reward seeking. Amygdala and thalamic inputs are also necessary for behavioral suppression, even though they both support self-stimulation and innervate different NAc subregions. These data suggest that efficient reward seeking relies on complementary activity across NAc cell types and inputs rather than opponent processes between them.

PMID: 32187545 [PubMed - as supplied by publisher]




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