Keyword search (4,163 papers available)

"Lahlou S" Authored Publications:

Title Authors PubMed ID
1 Augmenting glutamatergic, but not dopaminergic, activity in the nucleus accumbens shell disrupts responding to a discrete alcohol cue in an alcohol context Valyear MD; Brown A; Deyab G; Villaruel FR; Lahlou S; Caporicci-Dinucci N; Chaudhri N; 38185906
PSYCHOLOGY
2 Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts. Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N 32724058
PSYCHOLOGY
3 Modeling Relapse to Pavlovian Alcohol-Seeking in Rats Using Reinstatement and Spontaneous Recovery Paradigms. LeCocq MR, Lahlou S, Chahine M, Padillo LN, Chaudhri N 29969151
CSBN

 

Title:Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts.
Authors:Valyear MD,  Glovaci I,  Zaari A,  Lahlou S,  Trujillo-Pisanty I,  Andrew Chapman C,  Chaudhri N
Link:https://www.ncbi.nlm.nih.gov/pubmed/32724058
DOI:10.1038/s41467-020-17543-4
Publication:Nature communications
Keywords:
PMID:32724058 Category:Nat Commun Date Added:2020-07-30
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada.
2 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada. nadia.chaudhri@concordia.ca.

Description:

Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts.

Nat Commun. 2020 Jul 28;11(1):3764

Authors: Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N

Abstract

Context can influence reactions to environmental cues and this elemental process has implications for substance use disorder. Using an animal model, we show that an alcohol-associated context elevates entry into a fluid port triggered by a conditioned stimulus (CS) that predicted alcohol (CS-triggered alcohol-seeking). This effect persists across multiple sessions and, after it diminishes in extinction, the alcohol context retains the capacity to augment reinstatement. Systemically administered eticlopride and chemogenetic inhibition of ventral tegmental area (VTA) dopamine neurons reduce CS-triggered alcohol-seeking. Chemogenetically silencing VTA dopamine terminals in the nucleus accumbens (NAc) core reduces CS-triggered alcohol-seeking, irrespective of context, whereas silencing VTA dopamine terminals in the NAc shell selectively reduces the elevation of CS-triggered alcohol-seeking in an alcohol context. This dissociation reveals new roles for divergent mesolimbic dopamine circuits in the control of responding to a discrete cue for alcohol and in the amplification of this behaviour in an alcohol context.

PMID: 32724058 [PubMed - as supplied by publisher]




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