Keyword search (4,163 papers available)

"Lanphear BP" Authored Publications:

Title Authors PubMed ID
1 Prenatal exposure to polybrominated diphenyl ethers (PBDEs) and cognitive ability in early childhood. Azar N, Booij L, Muckle G, Arbuckle TE, Séguin JR, Asztalos E, Fraser WD, Lanphear BP, Bouchard MF 33395941
PSYCHOLOGY

 

Title:Prenatal exposure to polybrominated diphenyl ethers (PBDEs) and cognitive ability in early childhood.
Authors:Azar N,  Booij L,  Muckle G,  Arbuckle TE,  Séguin JR,  Asztalos E,  Fraser WD,  Lanphear BP,  Bouchard MF
Link:https://www.ncbi.nlm.nih.gov/pubmed/33395941
DOI:10.1016/j.envint.2020.106296
Publication:Environment international
Keywords:Cognitive ability;  Neurodevelopment;  Polybrominated diphenyl ethers;  Pregnancy cohort; 
PMID:33395941 Category:Environ Int Date Added:2021-01-06
Dept Affiliation: PSYCHOLOGY
1 Department of Psychology, Concordia University, Montréal, Québec, Canada; Sainte-Justine University Hospital Research Center, Québec, Canada.
2 Department of Psychology, Concordia University, Montréal, Québec, Canada; Sainte-Justine University Hospital Research Center, Québec, Canada; Department of Psychiatry and Addictology, Université de Montréal, Montréal, Québec, Canada.
3 School of Psychology, Université Laval, Ville de Québec, Québec, Canada.
4 Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada.
5 Sainte-Justine University Hospital Research Center, Québec, Canada; Department of Psychiatry and Addictology, Université de Montréal, Montréal, Québec, Canada.
6 Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.
7 Sainte-Justine University Hospital Research Center, Québec, Canada; Centre de recherche du CHUS (CHU de Sherbrooke), Université de Sherbrooke, Sherbrooke, Québec, Canada.
8 Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada; BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
9 Sainte-Justine University Hospital Research Center, Québec, Canada; Department of Environmental and Occupational Health, School of Public Health of the University of Montreal, Montréal, Québec, Canada. Electronic address: maryse.bouchard@umontreal.ca.

Description:

Prenatal exposure to polybrominated diphenyl ethers (PBDEs) and cognitive ability in early childhood.

Environ Int. 2021 Jan; 146:106296

Authors: Azar N, Booij L, Muckle G, Arbuckle TE, Séguin JR, Asztalos E, Fraser WD, Lanphear BP, Bouchard MF

Abstract

BACKGROUND: Prenatal exposure to polybrominated diphenyl ethers (PBDEs) has been associated with adverse neurodevelopmental outcomes in children, but evidence remains mixed regarding sex differences in this association.

OBJECTIVE: To examine the prospective association between prenatal PBDE exposure and cognitive ability in young children, as well as potential sex differences.

METHODS: The study was conducted in a multi-site Canadian pregnancy cohort recruited in 2008-11. PBDEs were measured in maternal plasma samples collected early in pregnancy. Cognitive ability was assessed using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) in children at age 3 years (mean = 3.4). Multiple linear regression was used to analyze the association between maternal PBDE plasma concentrations (lipid-standardized and log10-transformed) and Verbal, Performance, and Full Scale IQ scores on the whole sample and stratified by sex, adjusting for confounders.

RESULTS: The sample was composed of 592 children (291 boys and 301 girls). A tenfold increase in maternal blood PBDE concentration (sum of BDE-47, -99, -100, and -153) was associated with lower Full Scale scores in boys (-3.4 points; 95% CI: -7.0, 0.1), after adjusting for confounders. BDE-47 was the congener with the highest concentrations in maternal blood and a tenfold increase in exposure was associated with significantly lower Full Scale IQ scores in boys (-4.4 points; 95% CI: -7.9, -0.9), after adjusting for confounders. Verbal and Performance IQ scores were similarly associated with PBDE exposure. Maternal blood PBDE concentrations were not associated with IQ scores in girls.

CONCLUSIONS: Prenatal exposure to background levels of PBDEs, especially BDE-47, was associated with lower IQ scores in boys, but not in girls. Our results support that exposure to PBDEs during early development may be sex-dependent and detrimental to a child's neurodevelopmental trajectory.

PMID: 33395941 [PubMed - in process]




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