Keyword search (4,164 papers available)

"Levesque ML" Authored Publications:

Title Authors PubMed ID
1 Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins. Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L 28032437
PSYCHOLOGY
2 Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins. Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L 30089832
PSYCHOLOGY

 

Title:Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins.
Authors:Casey KF,  Levesque ML,  Szyf M,  Ismaylova E,  Verner MP,  Suderman M,  Vitaro F,  Brendgen M,  Dionne G,  Boivin M,  Tremblay RE,  Booij L
Link:https://www.ncbi.nlm.nih.gov/pubmed/28032437?dopt=Abstract
DOI:10.1002/hbm.23503
Publication:Human brain mapping
Keywords:MRI;  birth weight;  brain development;  brain morphometry;  child development;  epigenetics;  genome-wide;  neurodevelopment;  twin designs; 
PMID:28032437 Category:Hum Brain Mapp Date Added:2019-06-20
Dept Affiliation: PSYCHOLOGY
1 CHU Sainte-Justine Research Center, Montreal, Québec, Canada.
2 Department of Psychiatry, University of Montreal, Montreal, Québec, Canada.
3 Department of Pharmacology and Therapeutics, McGill University, Montreal, Québec, Canada.
4 Department of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
5 Psychoeducation, University of Montreal, Montreal, Québec, Canada.
6 Department of Psychology, UQAM, Montreal, Québec, Canada.
7 School of Psychology, University of Laval, Québec City, Québec, Canada.
8 Institute of Genetic, Neurobiological, and Social Foundations of Child Development, Tomsk State University, Tomsk, Siberia, Russian Federation.
9 Department of Psychology & Pediatrics, University of Montreal, Montreal, Québec, Canada.
10 School of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Ireland.
11 Department of Psychology, Concordia University, Montreal, Québec, Canada.
12 Department of Psychiatry, McGill University, Montreal, Québec, Canada.

Description:

Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins.

Hum Brain Mapp. 2017 04;38(4):2037-2050

Authors: Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L

Abstract

BACKGROUND: Several studies have shown that the in utero environment, which can be indexed by birth weight (BW), is associated with cortical morphology in adolescence and adulthood. Work in monozygotic (MZ) twins suggests that this association is driven by non-shared environmental factors. This correlation could be the result of in utero impacts on DNA methylation. The aim of the present study with MZ twins is to replicate the association between discordance in BW and brain morphology and test whether discordance in DNA methylation mediates this relationship.

METHODS: One hundred and four adolescent MZ twins (52 pairs, of which 42% were male pairs) who have been followed regularly since birth underwent T1 weighted structural MRI, and epigenome-wide assessment of DNA methylation from saliva at age 15.

RESULTS: Co-twins had very similar measures of DNA methylation and cortical morphology. Higher BW members of a twin pair had increased total cortical surface area, and decreased cortical thickness compared to their lower BW sibling. BW Discordance was positively associated with both cortical surface area and cortical volume discordance. Genes involved in neurodevelopment were tentatively identified as mediators of both the BW - cortical volume, and BW- cortical surface area relationships.

CONCLUSIONS: The association between BW and cortical morphology in adolescence appears to be attributable to in utero environmental effects, and DNA methylation may play a role in mediating this relationship. Hum Brain Mapp 38:2037-2050, 2017. © 2017 Wiley Periodicals, Inc.

PMID: 28032437 [PubMed - indexed for MEDLINE]




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