Keyword search (4,163 papers available)

"Li M" Authored Publications:

Title Authors PubMed ID
1 Report of the outcome of 6 years Blood Blister-like Aneurysm treatment using the clipping technique: a single center experience Ahrari I; Rahmanian A; Eqbal M; Ghavipisheh M; Namjoo-Moghadam A; Ahrari S; Mohammad Hosseini E; Jamali M; 40154532
HKAP
2 A protocol for trustworthy EEG decoding with neural networks Borra D; Magosso E; Ravanelli M; 39549492
ENCS
3 Generalization limits of Graph Neural Networks in identity effects learning D' Inverno GA; Brugiapaglia S; Ravanelli M; 39426036
ENCS
4 SpeechBrain-MOABB: An open-source Python library for benchmarking deep neural networks applied to EEG signals Borra D; Paissan F; Ravanelli M; 39265481
ENCS
5 DNA Replication across α-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase η Tomar R; Ghodke PP; Patra A; Smyth E; Pontarelli A; Copp W; Guengerich FP; Chaput JJ; Wilds CJ; Stone MP; Egli M; 39259676
CHEMBIOCHEM
6 Urban sprawl in Canada: Values in all 33 Census Metropolitan Areas and corresponding 469 Census Subdivisions between 1991 and 2011 Pourali M; Townsend C; Kross A; Guindon A; Jaeger JAG; 35242923
LIBRARY
7 Who Cares? Preferences for Formal and Informal Care Among Older Adults in Québec Lee K; Revelli M; Dickson D; Marier P; 34886702
CONCORDIA
8 Beyond ribose and phosphate: Selected nucleic acid modifications for structure-function investigations and therapeutic applications Liczner C; Duke K; Juneau G; Egli M; Wilds CJ; 33981365
CHEMBIOCHEM
9 Overestimation of Postpartum Depression Prevalence Based on a 5-item Version of the EPDS: Systematic Review and Individual Participant Data Meta-analysis Thombs BD; Levis B; Lyubenova A; Neupane D; Negeri Z; Wu Y; Sun Y; He C; Krishnan A; Vigod SN; Bhandari PM; Imran M; Rice DB; Azar M; Chiovitti MJ; Saadat N; Riehm KE; Boruff JT; Cuijpers P; Gilbody S; Ioannidis JPA; Kloda LA; Patten SB; Shrier I; Ziegelstein RC; Comeau L; Mitchell ND; Tonelli M; Barnes J; Beck CT; Bindt C; Figueiredo B; Helle N; Howard LM; Kohlhoff J; Kozinszky Z; Leonardou AA; Radoš SN; Quispel C; Rochat TJ; Stein A; Stewart RC; Tadinac M; Tandon SD; Tendais I; Töreki A; Tran TD; Trevillion K; Turner K; Vega-Dienstmaier JM; Benedetti A; 33104415
LIBRARY
10 Depression prevalence based on the Edinburgh Postnatal Depression Scale compared to Structured Clinical Interview for DSM DIsorders classification: Systematic review and individual participant data meta-analysis Lyubenova A; Neupane D; Levis B; Wu Y; Sun Y; He C; Krishnan A; Bhandari PM; Negeri Z; Imran M; Rice DB; Azar M; Chiovitti MJ; Saadat N; Riehm KE; Boruff JT; Ioannidis JPA; Cuijpers P; Gilbody S; Kloda LA; Patten SB; Shrier I; Ziegelstein RC; Comeau L; Mitchell ND; Tonelli M; Vigod SN; Aceti F; Barnes J; Bavle AD; Beck CT; Bindt C; Boyce PM; Bunevicius A; Chaudron LH; Favez N; Figueiredo B; Garcia-Esteve L; Giardinelli L; Helle N; Howard LM; Kohlhoff J; Kusminskas L; Kozinszky Z; Lelli L; Leonardou AA; Meuti V; Radoš SN; García PN; Pawlby SJ; Quispel C; Robertson-Blackmore E; Rochat TJ; Sharp DJ; Siu BWM; Stein A; Stewart RC; Tadinac M; Tandon SD; Tendais I; Töreki A; Torres-Giménez A; Tran TD; Trevillion K; Turner K; Vega-Dienstmaier JM; Benedetti A; Thombs BD; 33089942
CONCORDIA
11 Probability of major depression diagnostic classification based on the SCID, CIDI and MINI diagnostic interviews controlling for Hospital Anxiety and Depression Scale - Depression subscale scores: An individual participant data meta-analysis of 73 primary studies Wu Y; Levis B; Sun Y; Krishnan A; He C; Riehm KE; Rice DB; Azar M; Yan XW; Neupane D; Bhandari PM; Imran M; Chiovitti MJ; Saadat N; Boruff JT; Cuijpers P; Gilbody S; McMillan D; Ioannidis JPA; Kloda LA; Patten SB; Shrier I; Ziegelstein RC; Henry M; Ismail Z; Loiselle CG; Mitchell ND; Tonelli M; Al-Adawi S; Beraldi A; Braeken APBM; Büel-Drabe N; Bunevicius A; Carter G; Chen CK; Cheung G; Clover K; Conroy RM; Cukor D; da Rocha E Silva CE; Dabscheck E; Daray FM; Douven E; Downing MG; Feinstein A; Ferentinos PP; Fischer FH; Flint AJ; Fujimori M; Gallagher P; Gandy M; Goebel S; Grassi L; Härter M; Jenewein J; Jetté N; Julião M; Kim JM; Kim SW; Kjærgaard M; Köhler S; Loosman WL; Löwe B; Martin-Santos R; Massardo L; Matsuoka Y; Mehnert A; Michopoulos I; Misery L; Navines R; O' Donnell ML; Öztürk A; Peceliuniene J; Pintor L; Ponsford JL; Quinn TJ; Reme SE; Reuter K; Rooney AG; Sánchez-González R; Schwarzbold ML; Senturk Cankorur V; Shaaban J; Sharpe L; Sharpe M; Simard S; Singer S; Stafford L; Stone J; Sultan S; Teixeira AL; Tiringer I; Turner A; Walker J; Walterfang M; Wang LJ; White J; Wong DK; Benedetti A; Thombs BD; 31911325
LIBRARY
12 Comparison of major depression diagnostic classification probability using the SCID, CIDI, and MINI diagnostic interviews among women in pregnancy or postpartum: An individual participant data meta-analysis Levis B; McMillan D; Sun Y; He C; Rice DB; Krishnan A; Wu Y; Azar M; Sanchez TA; Chiovitti MJ; Bhandari PM; Neupane D; Saadat N; Riehm KE; Imran M; Boruff JT; Cuijpers P; Gilbody S; Ioannidis JPA; Kloda LA; Patten SB; Shrier I; Ziegelstein RC; Comeau L; Mitchell ND; Tonelli M; Vigod SN; Aceti F; Alvarado R; Alvarado-Esquivel C; Bakare MO; Barnes J; Beck CT; Bindt C; Boyce PM; Bunevicius A; Couto TCE; Chaudron LH; Correa H; de Figueiredo FP; Eapen V; Fernandes M; Figueiredo B; Fisher JRW; Garcia-Esteve L; Giardinelli L; Helle N; Howard LM; Khalifa DS; Kohlhoff J; Kusminskas L; Kozinszky Z; Lelli L; Leonardou AA; Lewis BA; Maes M; Meuti V; Nakic Radoš S; Navarro García P; Nishi D; Okitundu Luwa E-Andjafono D; Robertson-Blackmore E; Rochat TJ; Rowe HJ; Siu BWM; Skalkidou A; Stein A; Stewart RC; Su KP; Sundström-Poromaa I; Tadinac M; Tandon SD; Tendais I; Thiagayson P; Töreki A; Torres-Giménez A; Tran TD; Trevillion K; Turner K; Vega-Dienstmaier JM; Wynter K; Yonkers KA; Benedetti A; Thombs BD; 31568624
LIBRARY
13 Simulation and computer modeling of asphaltene in different solvents on oil-water interfaces using a molecular dynamic methodology. Yuan J, Elektorowicz M, Chen Z, Segun GA, Vakili M, Zhong L, Wang B, Zhu J, Wu Y 31542686
ENCS
14 Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η opposite Intrastrand Cross-Linked DNA. O'Flaherty DK, Guengerich FP, Egli M, Wilds CJ 26624500
CHEMBIOCHEM
15 Diagnostic accuracy of the Depression subscale of the Hospital Anxiety and Depression Scale (HADS-D) for detecting major depression: protocol for a systematic review and individual patient data meta-analyses. Thombs BD, Benedetti A, Kloda LA, Levis B, Azar M, Riehm KE, Saadat N, Cuijpers P, Gilbody S, Ioannidis JP, McMillan D, Patten SB, Shrier I, Steele RJ, Ziegelstein RC, Loiselle CG, Henry M, Ismail Z, Mitchell N, Tonelli M 27075844
LIBRARY
16 SnowyOwl: accurate prediction of fungal genes by using RNA-Seq and homology information to select among ab initio models. Reid I, O'Toole N, Zabaneh O, Nourzadeh R, Dahdouli M, Abdellateef M, Gordon PM, Soh J, Butler G, Sensen CW, Tsang A 24980894
CSFG
17 A Lithium-Sulfur Battery using a 2D Current Collector Architecture with a Large-Sized Sulfur Host Operated under High Areal Loading and Low E/S Ratio. Li M, Zhang Y, Bai Z, Liu WW, Liu T, Gim J, Jiang G, Yuan Y, Luo D, Feng K, Yassar RS, Wang X, Chen Z, Lu J 30368935
ENCS
18 Lesion Orientation of O4-Alkylthymidine Influences Replication by Human DNA Polymerase η. O'Flaherty DK, Patra A, Su Y, Guengerich FP, Egli M, Wilds CJ 27574558
CHEMBIOCHEM
19 O6-2'-Deoxyguanosine-butylene-O6-2'-deoxyguanosine DNA Interstrand Cross-Links Are Replication-Blocking and Mutagenic DNA Lesions. Xu W, Kool D, O'Flaherty DK, Keating AM, Sacre L, Egli M, Noronha A, Wilds CJ, Zhao L 27768841
CHEMBIOCHEM
20 The Effect of Synbiotic Supplementation on Growth Parameters in Mild to Moderate FTT Children Aged 2-5 Years. Aflatoonian M, Taghavi Ardakani A, Modarresi SZ, Modaresi V, Karimi M, Ordooei M, Vakili M, Pakseresht B 30627885
CHEMBIOCHEM
21 Multimodal 18F-Fluciclovine PET/MRI and Ultrasound-Guided Neurosurgery of an Anaplastic Oligodendroglioma. Karlberg A, Berntsen EM, Johansen H, Myrthue M, Skjulsvik AJ, Reinertsen I, Esmaeili M, Dai HY, Xiao Y, Rivaz H, Borghammer P, Solheim O, Eikenes L 28844925
PERFORM
22 The spinal and cerebral profile of adult spinal-muscular atrophy: A multimodal imaging study. Querin G, El Mendili MM, Lenglet T, Behin A, Stojkovic T, Salachas F, Devos D, Le Forestier N, Del Mar Amador M, Debs R, Lacomblez L, Meninger V, Bruneteau G, Cohen-Adad J, Lehéricy S, Laforêt P, Blancho S, Benali H, Catala M, Li M, Marchand-Pauvert V, Hogrel JY, Bede P, Pradat PF 30522974
NA
23 A comparison of muscle activation and knee mechanics during gait between patients with non-traumatic and post-traumatic knee osteoarthritis. Robbins SM, Morelli M, Martineau PA, St-Onge N, Boily M, Dimentberg R, Antoniou J 30898621
PERFORM

 

Title:O6-2'-Deoxyguanosine-butylene-O6-2'-deoxyguanosine DNA Interstrand Cross-Links Are Replication-Blocking and Mutagenic DNA Lesions.
Authors:Xu WKool DO'Flaherty DKKeating AMSacre LEgli MNoronha AWilds CJZhao L
Link:https://www.ncbi.nlm.nih.gov/pubmed/27768841?dopt=Abstract
Publication:
Keywords:
PMID:27768841 Category:Chem Res Toxicol Date Added:2019-05-31
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University , 7141 Sherbrooke Street West, Montréal, Québec H4B 1R6, Canada.
2 Department of Biochemistry, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-0146, United States.

Description:

O6-2'-Deoxyguanosine-butylene-O6-2'-deoxyguanosine DNA Interstrand Cross-Links Are Replication-Blocking and Mutagenic DNA Lesions.

Chem Res Toxicol. 2016 11 21;29(11):1872-1882

Authors: Xu W, Kool D, O'Flaherty DK, Keating AM, Sacre L, Egli M, Noronha A, Wilds CJ, Zhao L

Abstract

DNA interstrand cross-links (ICLs) are cytotoxic DNA lesions derived from reactions of DNA with a number of anti-cancer reagents as well as endogenous bifunctional electrophiles. Deciphering the DNA repair mechanisms of ICLs is important for understanding the toxicity of DNA cross-linking agents and for developing effective chemotherapies. Previous research has focused on ICLs cross-linked with the N7 and N2 atoms of guanine as well as those formed at the N6 atom of adenine; however, little is known about the mutagenicity of O6-dG-derived ICLs. Although less abundant, O6-alkylated guanine DNA lesions are chemically stable and highly mutagenic. Here, O6-2'-deoxyguanosine-butylene-O6-2'-deoxyguanosine (O6-dG-C4-O6-dG) is designed as a chemically stable ICL, which can be induced by the action of bifunctional alkylating agents. We investigate the DNA replication-blocking and mutagenic properties of O6-dG-C4-O6-dG ICLs during an important step in ICL repair, translesion DNA synthesis (TLS). The model replicative DNA polymerase (pol) Sulfolobus solfataricus P2 DNA polymerase B1 (Dpo1) is able to incorporate a correct nucleotide opposite the cross-linked template guanine of ICLs with low efficiency and fidelity but cannot extend beyond the ICLs. Translesion synthesis by human pol ? is completely inhibited by O6-dG-C4-O6-dG ICLs. Moderate bypass activities are observed for human pol ? and S. solfataricus P2 DNA polymerase IV (Dpo4). Among the pols tested, pol ? exhibits the highest bypass activity; however, 70% of the bypass products are mutagenic containing substitutions or deletions. The increase in the size of unhooked repair intermediates elevates the frequency of deletion mutation. Lastly, the importance of pol ? in O6-dG-derived ICL bypass is demonstrated using whole cell extracts of Xeroderma pigmentosum variant patient cells and those complemented with pol ?. Together, this study provides the first set of biochemical evidence for the mutagenicity of O6-dG-derived ICLs.

PMID: 27768841 [PubMed - indexed for MEDLINE]





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