PERFORM Publications

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Title		Authors	PubMed ID
1	Efficient self-supervised Barlow Twins from limited tissue slide cohorts for colonic pathology diagnostics	Notton C; Sharma V; Quoc-Huy Trinh V; Chen L; Xu M; Varma S; Hosseini MS;	41793844 CONCORDIA
2	Parvalbumin interneuron loss mediates repeated anesthesia-induced memory deficits in mice	Roque PS; Thörn Perez C; Hooshmandi M; Wong C; Eslamizade MJ; Heshmati S; Brown N; Sharma V; Lister KC; Goyon VM; Neagu-Lund L; Shen C; Daccache N; Sato H; Sato T; Mogil JS; Nader K; Gkogkas CG; Iordanova MD; Prager-Khoutorsky M; McBride HM; Lacaille JC; Wykes L; Schricker T; Khoutorsky A;	36394958 PSYCHOLOGY
3	Obestatin and growth hormone reveal the interaction of central obesity and other cardiometabolic risk factors of metabolic syndrome.	Yu AP, Ugwu FN, Tam BT, Lee PH, Ma V, Pang S, Chow AS, Cheng KK, Lai CW, Wong CS, Siu PM	32218464 HKAP

Title:	Obestatin and growth hormone reveal the interaction of central obesity and other cardiometabolic risk factors of metabolic syndrome.
Authors:	Yu AP, Ugwu FN, Tam BT, Lee PH, Ma V, Pang S, Chow AS, Cheng KK, Lai CW, Wong CS, Siu PM
Link:	https://www.ncbi.nlm.nih.gov/pubmed/32218464?dopt=Abstract
DOI:	10.1038/s41598-020-62271-w
Publication:	Scientific reports
Keywords:
PMID:	32218464	Category:	Sci Rep	Date Added:	2020-03-29
Dept Affiliation:	HKAP 1 Division of Kinesiology, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. 2 Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China. 3 Department of Health, Kinesiology and Applied Physiology, Concordia University, Montreal, QC, Canada. 4 School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China. 5 Singapore Institute of Technology, Singapore, Singapore. 6 Division of Kinesiology, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. pmsiu@hku.hk.

Description:

Obestatin and growth hormone reveal the interaction of central obesity and other cardiometabolic risk factors of metabolic syndrome.

Sci Rep. 2020 Mar 26;10(1):5495

Authors: Yu AP, Ugwu FN, Tam BT, Lee PH, Ma V, Pang S, Chow AS, Cheng KK, Lai CW, Wong CS, Siu PM

Abstract

Metabolic syndrome (MetS) is a multi-factorial disorder including central obesity (CO), insulin resistance, hyperglycemia, dyslipidemia and hypertension which increases the risk of diabetes mellitus and cardiovascular diseases. CO is considered as an essential component of MetS according to International Diabetes Federation (IDF), which may further modulate distinct signalling pathways compared with the other four MetS risk factors. Given that ghrelin signalling and the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis regulates energy balance and metabolic homeostasis, this study examined the changes in various ghrelin products and circulating hormones in response to the interaction between CO and other MetS components including blood pressure, fasting blood glucose, triglycerides, and high-density lipoprotein cholesterol in 133 Hong Kong Chinese adults. Circulating obestatin and GH were increased and reduced, respectively, by either CO or the other 4-risk factor cluster. These changes were further augmented by the presence of all MetS risk factors. However, changes of ghrelin levels were not mediated by CO but the other MetS risk factors. Our findings suggest that CO does not predict all the dysregulation of signalling pathways in individuals with MetS. Although CO and other MetS may share common signalling targets (i.e., obestatin and GH), CO does not contribute to the perturbation of ghrelin signalling.

PMID: 32218464 [PubMed - as supplied by publisher]

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