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PubMed Publications| Keyword search (4,163 papers available) |  |
"Prem Ponka" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Do Mammalian Cells Really Need to Export and Import Heme? | Prem Ponka | 28254242 CERMM |
| Title: | Do Mammalian Cells Really Need to Export and Import Heme? | ||||
| Authors: | Prem Ponka | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/28254242/ | ||||
| DOI: | 10.1016/j.tibs.2017.01.006 | ||||
| Publication: | Trends in biochemical sciences | ||||
| Keywords: | |||||
| PMID: | 28254242 | Category: | Trends Biochem Sci | Date Added: | 2019-05-31 |
| Dept Affiliation: |
CERMM
1 Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, H3T 1E2, Canada; Department of Physiology, McGill University, Montréal, QC, H3G 1Y6, Canada. Electronic address: prem.ponka@mcgill.ca. 2 Spartan Bioscience Inc., Ottawa, ON, K2H 1B2, Canada; High Impact Editing, Ottawa, ON, K1B 3Y6, Canada. 3 Department of Chemistry and Biochemistry, Centre for Research in Molecular Modeling and PROTEO, Concordia University, Montréal, QC, H4B 1R, Canada. 4 Department of Chemistry, McGill University, Montréal, QC, H3A 0B8, Canada. 5 Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, H3T 1E2, Canada; Department of Physiology, McGill University, Montréal, QC, H3G 1Y6, Canada. |
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Description: |
Heme is a cofactor that is essential to almost all forms of life. The production of heme is a balancing act between the generation of the requisite levels of the end-product and protection of the cell and/or organism against any toxic substrates, intermediates and, in this case, end-product. In this review, we provide an overview of our understanding of the formation and regulation of this metallocofactor and discuss new research on the cell biology of heme homeostasis, with a focus on putative... |
