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PubMed Publications| Keyword search (4,164 papers available) |  |
"Rahman MS" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Quantifying imbalanced classification methods for leukemia detection | Depto DS; Rizvee MM; Rahman A; Zunair H; Rahman MS; Mahdy MRC; | 36516574 ENCS |
| 2 | A comparative analysis of deep learning architectures on high variation malaria parasite classification dataset. | Rahman A, Zunair H, Reme TR, Rahman MS, Mahdy MRC | 33465520 ENCS |
| 3 | Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography-High-Resolution Mass Spectrometry | Slobodchikova I; Sivakumar R; Rahman MS; Vuckovic D; | 31344861 CBAMS |
| 4 | Detecting glycogen in peripheral blood mononuclear cells with periodic acid schiff staining. | Tabatabaei Shafiei M, Carvajal Gonczi CM, Rahman MS, East A, François J, Darlington PJ | 25548935 PERFORM |
| Title: | Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography-High-Resolution Mass Spectrometry | ||||
| Authors: | Slobodchikova I, Sivakumar R, Rahman MS, Vuckovic D | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/31344861/ | ||||
| DOI: | 10.3390/toxins11080433 | ||||
| Publication: | Toxins | ||||
| Keywords: | biomonitoring; glucuronidation; high-resolution mass spectrometry (HRMS); human; metabolism; microsomal incubation; mycotoxins; | ||||
| PMID: | 31344861 | Category: | Toxins (Basel) | Date Added: | 2019-08-07 |
| Dept Affiliation: |
CBAMS
1 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. 2 Centre for Biological Applications of Mass Spectrometry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. 3 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. dajana.vuckovic@concordia.ca. 4 Centre for Biological Applications of Mass Spectrometry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada. dajana.vuckovic@concordia.ca. |
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Description: |
Routine mycotoxin biomonitoring methods do not include many mycotoxin phase I and phase II metabolites, which may significantly underestimate mycotoxin exposure especially for heavily metabolized mycotoxins. Additional research efforts are also needed to measure metabolites in vivo after exposure and to establish which mycotoxin metabolites should be prioritized for the inclusion during large-scale biomonitoring efforts. The objective of this study was to perform human in vitro microsomal incubations of 17 mycotoxins and systematically characterize all resulting metabolites using liquid chromatography-high-resolution mass spectrometry (LC-HRMS). The results obtained were then used to build a comprehensive LC-MS library and expand a validated 17-mycotoxin method for exposure monitoring to screening of additional 188 metabolites, including 100 metabolites reported for the first time. The final method represents one of the most comprehensive LC-HRMS methods for mycotoxin biomonitoring or metabolism/fate studies. |
