Keyword search (4,163 papers available)

"Sciascia JM" Authored Publications:

Title Authors PubMed ID
1 Comparing ABA, AAB, and ABC Renewal of Appetitive Pavlovian Conditioned Responding in Alcohol- and Sucrose-Trained Male Rats. Khoo SY, Sciascia JM, Brown A, Chaudhri N 32116588
PSYCHOLOGY
2 The medial prefrontal cortex is required for responding to alcohol-predictive cues but only in the absence of alcohol delivery. Khoo SY, Sciascia JM, Pettorelli A, Maddux JN, Chaudhri N 31070082
PSYCHOLOGY
3 Vendor differences in alcohol consumption and the contribution of dopamine receptors to Pavlovian-conditioned alcohol-seeking in Long-Evans rats. Sparks LM, Sciascia JM, Ayorech Z, Chaudhri N 24096535
PSYCHOLOGY
4 Alcohol-Seeking Triggered by Discrete Pavlovian Cues is Invigorated by Alcohol Contexts and Mediated by Glutamate Signaling in the Basolateral Amygdala. Sciascia JM, Reese RM, Janak PH, Chaudhri N 25953360
PSYCHOLOGY

 

Title:Alcohol-Seeking Triggered by Discrete Pavlovian Cues is Invigorated by Alcohol Contexts and Mediated by Glutamate Signaling in the Basolateral Amygdala.
Authors:Sciascia JM,  Reese RM,  Janak PH,  Chaudhri N
Link:https://www.ncbi.nlm.nih.gov/pubmed/25953360?dopt=Abstract
Publication:
Keywords:
PMID:25953360 Category:Neuropsychopharmacology Date Added:2019-05-31
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology/FRQS Groupe de Recherche en Neurobiologie Comportementale, Department of Psychology, Concordia University, Montreal, QC, Canada.
2 Departments of Psychological and Brain Sciences and Neuroscience, Johns Hopkins University, Baltimore, MD, USA.

Description:

Alcohol-Seeking Triggered by Discrete Pavlovian Cues is Invigorated by Alcohol Contexts and Mediated by Glutamate Signaling in the Basolateral Amygdala.

Neuropsychopharmacology. 2015 Nov;40(12):2801-12

Authors: Sciascia JM, Reese RM, Janak PH, Chaudhri N

Abstract

The environmental context in which a discrete Pavlovian conditioned stimulus (CS) is experienced can profoundly impact conditioned responding elicited by the CS. We hypothesized that alcohol-seeking behavior elicited by a discrete CS that predicted alcohol would be influenced by context and require glutamate signaling in the basolateral amygdala (BLA). Male, Long-Evans rats were allowed to drink 15% ethanol (v/v) until consumption stabilized. Next, rats received Pavlovian conditioning sessions in which a 10?s CS (15 trials/session) was paired with ethanol (0.2?ml/CS). Entries into a port where ethanol was delivered were measured. Pavlovian conditioning occurred in a specific context (alcohol context) and was alternated with sessions in a different context (non-alcohol context) where neither the CS nor ethanol was presented. At test, the CS was presented without ethanol in the alcohol context or the non-alcohol context, following a bilateral microinfusion (0.3?µl/hemisphere) of saline or the AMPA glutamate receptor antagonist NBQX (2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt) in the BLA (0, 0.3, or 1.0?µg/0.3?µl). The effect of NBQX (0, 0.3?µg/0.3?µl) in the caudate putamen (CPu) on CS responding in the non-alcohol context was also tested. The discrete alcohol CS triggered more alcohol-seeking behavior in the alcohol context than the non-alcohol context. NBQX in the BLA reduced CS responding in both contexts but had no effect in the CPu. These data indicate that AMPA glutamate receptors in the BLA are critical for alcohol-seeking elicited by a discrete CS and that behavior triggered by the CS is strongly invigorated by an alcohol context.

PMID: 25953360 [PubMed - indexed for MEDLINE]




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