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PubMed Publications| Keyword search (4,163 papers available) |  |
"Sen S" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | The effect of 14 days Actovegin administration with or without high intensity training on exercise capacity and skeletal muscle mitochondrial respiration | Hassø RK; Lindtofte S; Kosik B; Bergdahl A; Larsen S; | 41553522 HKAP |
| 2 | Actovegin improves skeletal muscle mitochondrial respiration and functional aerobic capacity in a type 1 diabetic male murine model | Kosik B; Larsen S; Bergdahl A; | 37913525 HKAP |
| 3 | Dopamine dysregulation in Parkinson's disease flattens the pleasurable urge to move to musical rhythms | Pando-Naude V; Matthews TE; Højlund A; Jakobsen S; Østergaard K; Johnsen E; Garza-Villarreal EA; Witek MAG; Penhune V; Vuust P; | 37724707 PSYCHOLOGY |
| 4 | Why process-level Scope 3 accounting is needed for delivering supply chain greenhouse gas emission reduction | Emborg M; Lloyd S; Olsen S; | 37641449 JMSB |
| 5 | Developing EMR-based algorithms to Identify hospital adverse events for health system performance evaluation and improvement: Study protocol | Wu G; Eastwood C; Zeng Y; Quan H; Long Q; Zhang Z; Ghali WA; Bakal J; Boussat B; Flemons W; Forster A; Southern DA; Knudsen S; Popowich B; Xu Y; | 36197944 ENCS |
| 6 | Structural basis of 3'-end poly(A) RNA recognition by LARP1 | Kozlov G; Mattijssen S; Jiang J; Nyandwi S; Sprules T; Iben JR; Coon SL; Gaidamakov S; Noronha AM; Wilds CJ; Maraia RJ; Gehring K; | 35979957 CHEMBIOCHEM |
| 7 | War and reintegration for girls and young women in northern Uganda: A scoping review | Savard M; Michaelsen S; | 34479000 EDUCATION |
| 8 | L’obésité chez l’adulte : ligne directrice de pratique clinique. | Wharton S, Lau DCW, Vallis M, Sharma AM, Biertho L, Campbell-Scherer D, Adamo K, Alberga A, Bell R, Boulé N, Boyling E, Brown J, Calam B, Clarke C, Crowshoe L, Divalentino D, Forhan M, Freedhoff Y, Gagner M, Glazer S, Grand C, Green M, Hahn M, Hawa R, Henderson R, Hong D, Hung P, Janssen I, Jacklin K, Johnson-Stoklossa C, Kemp A, Kirk S, Kuk J, Langlois MF, Lear S, McInnes A, Macklin D, Naji L, Manjoo P, Morin MP, Nerenberg K, Patton I, Pedersen S, Pereira L, Piccinini-Vallis H, Poddar M, Poirier P, Prud | 33288515 HKAP |
| 9 | Obesity in adults: a clinical practice guideline. | Wharton S, Lau DCW, Vallis M, Sharma AM, Biertho L, Campbell-Scherer D, Adamo K, Alberga A, Bell R, Boulé N, Boyling E, Brown J, Calam B, Clarke C, Crowshoe L, Divalentino D, Forhan M, Freedhoff Y, Gagner M, Glazer S, Grand C, Green M, Hahn M, Hawa R, Henderson R, Hong D, Hung P, Janssen I, Jacklin K, Johnson-Stoklossa C, Kemp A, Kirk S, Kuk J, Langlois MF, Lear S, McInnes A, Macklin D, Naji L, Manjoo P, Morin MP, Nerenberg K, Patton I, Pedersen S, Pereira L, Piccinini-Vallis H, Poddar M, Poirier P, Prud | 32753461 HKAP |
| 10 | Size reductions and genomic changes within two generations in wild walleye populations: associated with harvest? | Bowles E, Marin K, Mogensen S, MacLeod P, Fraser DJ | 32684951 CONCORDIA |
| 11 | Origin and evolution of the genus Piper in Peninsular India. | Sen S, Dayanandan S, Davis T, Ganesan R, Jagadish MR, Mathew PJ, Ravikanth G | 31132521 CSFG |
| Title: | Structural basis of 3'-end poly(A) RNA recognition by LARP1 | ||||
| Authors: | Kozlov G, Mattijssen S, Jiang J, Nyandwi S, Sprules T, Iben JR, Coon SL, Gaidamakov S, Noronha AM, Wilds CJ, Maraia RJ, Gehring K | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/35979957/ | ||||
| DOI: | 10.1093/nar/gkac696 | ||||
| Publication: | Nucleic acids research | ||||
| Keywords: | |||||
| PMID: | 35979957 | Category: | Date Added: | 2022-08-18 | |
| Dept Affiliation: |
CHEMBIOCHEM
1 Department of Biochemistry, McGill University, Montréal, Canada. 2 Centre de recherche en biologie structurale, McGill University, Montréal, Canada. 3 Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States. 4 Quebec/Eastern Canada NMR Centre, McGill University, Montréal, Canada. 5 Department of Chemistry and Biochemistry, Concordia University, Montréal, Canada. |
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Description: |
La-related proteins (LARPs) comprise a family of RNA-binding proteins involved in a wide range of posttranscriptional regulatory activities. LARPs share a unique tandem of two RNA-binding domains, La motif (LaM) and RNA recognition motif (RRM), together referred to as a La-module, but vary in member-specific regions. Prior structural studies of La-modules reveal they are pliable platforms for RNA recognition in diverse contexts. Here, we characterize the La-module of LARP1, which plays an important role in regulating synthesis of ribosomal proteins in response to mTOR signaling and mRNA stabilization. LARP1 has been well characterized functionally but no structural information exists for its La-module. We show that unlike other LARPs, the La-module in LARP1 does not contain an RRM domain. The LaM alone is sufficient for binding poly(A) RNA with submicromolar affinity and specificity. Multiple high-resolution crystal structures of the LARP1 LaM domain in complex with poly(A) show that it is highly specific for the RNA 3'-end, and identify LaM residues Q333, Y336 and F348 as the most critical for binding. Use of a quantitative mRNA stabilization assay and poly(A) tail-sequencing demonstrate functional relevance of LARP1 RNA binding in cells and provide novel insight into its poly(A) 3' protection activity. |
