Keyword search (4,163 papers available)

"Shetty C" Authored Publications:

Title Authors PubMed ID
1 Imidazole-Mediated Dual Location Disassembly of Acid-Degradable Intracellular Drug Delivery Block Copolymer Nanoassemblies Jazani AM; Shetty C; Movasat H; Bawa KK; Oh JK; 34050688
CHEMBIOCHEM
2 Dual Reduction/Acid-Responsive Disassembly and Thermoresponsive Tunability of Degradable Double Hydrophilic Block Copolymer. Maruya-Li K, Shetty C, Moini Jazani A, Arezi N, Oh JK 32118189
CHEMBIOCHEM
3 PLA-Based Triblock Copolymer Micelles Exhibiting Dual Acidic pH/Reduction Responses at Dual Core and Core/Corona Interface Locations. Bawa KK, Jazani AM, Shetty C, Oh JK 30286258
CHEMBIOCHEM

 

Title:Dual Reduction/Acid-Responsive Disassembly and Thermoresponsive Tunability of Degradable Double Hydrophilic Block Copolymer.
Authors:Maruya-Li K,  Shetty C,  Moini Jazani A,  Arezi N,  Oh JK
Link:https://www.ncbi.nlm.nih.gov/pubmed/32118189?dopt=Abstract
DOI:10.1021/acsomega.9b04430
Publication:ACS omega
Keywords:
PMID:32118189 Category:ACS Omega Date Added:2020-03-03
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University, Montreal, Quebec H4B 1R6, Canada.

Description:

Dual Reduction/Acid-Responsive Disassembly and Thermoresponsive Tunability of Degradable Double Hydrophilic Block Copolymer.

ACS Omega. 2020 Feb 25;5(7):3734-3742

Authors: Maruya-Li K, Shetty C, Moini Jazani A, Arezi N, Oh JK

Abstract

We report a thermoresponsive double hydrophilic block copolymer degradable in response to dual reduction and acidic pH at dual locations. The copolymer consists of a poly(ethylene oxide) block covalently connected through an acid-labile acetal linkage with a thermoresponsive polymethacrylate block containing pendant oligo(ethylene oxide) and disulfide groups. The copolymer undergoes temperature-driven self-assembly in water to form nanoassemblies with acetal linkages at the core/corona interface and disulfide pendants in the core, exhibiting dual reduction/acid responses at dual locations. The physically assembled nanoaggregates are converted to disulfide-core-crosslinked nanogels through disulfide-thiol exchange reaction, retaining enhanced colloidal stability, yet degraded to water-soluble unimers upon reduction/acid-responsive degradation. Further, the copolymer exhibits improved tunability of thermoresponsive property upon the cleavage of junction acetal and pendant disulfide linkages individually and in combined manner. This work suggests that dual location dual reduction/acid-responsive degradation is a versatile strategy toward effective drug delivery exhibiting disulfide-core-crosslinking capability and disassembly as well as improved thermoresponsive tunability.

PMID: 32118189 [PubMed]




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