Keyword search (4,163 papers available)

"Shi S" Authored Publications:

Title Authors PubMed ID
1 Development of an evaporation-driven sampling system for the in situ long-term monitoring of heavy metals in surface water Li X; Ma H; Shi S; Tian X; Nie L; Han X; Sun J; Chen Z; Li J; Chen K; 41886856
ENCS
2 Design, Analysis, and Prototyping of a Multifunctional Digital Twin-Enabled Aerospace Drilling End-Effector Deployable by a Collaborative Robot Kazemiesfahani M; Dilfanian E; Monsarrat B; Hajzargarbashi S; 41471503
ENCS
3 Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator. Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA 31604953
BIOLOGY
4 Expression of catalytically efficient xylanases from thermophilic fungus Malbranchea cinnamomea for synergistically enhancing hydrolysis of lignocellulosics. Basotra N, Joshi S, Satyanarayana T, Pati PK, Tsang A, Chadha BS 29174359
CSFG

 

Title:Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator.
Authors:Riglar DT,  Richmond DL,  Potvin-Trottier L,  Verdegaal AA,  Naydich AD,  Bakshi S,  Leoncini E,  Lyon LG,  Paulsson J,  Silver PA
Link:https://www.ncbi.nlm.nih.gov/pubmed/31604953?dopt=Abstract
DOI:10.1038/s41467-019-12638-z
Publication:Nature communications
Keywords:
PMID:31604953 Category:Nat Commun Date Added:2019-10-13
Dept Affiliation: BIOLOGY
1 Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
2 Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
3 Department of Infectious Disease, Imperial College London, London, UK.
4 Image and Data Analysis Core, Harvard Medical School, Boston, MA, USA.
5 Biology Department, Concordia University, Montreal, QC, Canada.
6 Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA, USA.
7 Department of Engineering, Cambridge University, Cambridge, UK.
8 Department of Systems Biology, Harvard Medical School, Boston, MA, USA. Pamela_Silver@hms.harvard.edu.
9 Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. Pamela_Silver@hms.harvard.edu.

Description:

Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator.

Nat Commun. 2019 Oct 11;10(1):4665

Authors: Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA

Abstract

Synthetic gene oscillators have the potential to control timed functions and periodic gene expression in engineered cells. Such oscillators have been refined in bacteria in vitro, however, these systems have lacked the robustness and precision necessary for applications in complex in vivo environments, such as the mammalian gut. Here, we demonstrate the implementation of a synthetic oscillator capable of keeping robust time in the mouse gut over periods of days. The oscillations provide a marker of bacterial growth at a single-cell level enabling quantification of bacterial dynamics in response to inflammation and underlying variations in the gut microbiota. Our work directly detects increased bacterial growth heterogeneity during disease and differences between spatial niches in the gut, demonstrating the deployment of a precise engineered genetic oscillator in real-life settings.

PMID: 31604953 [PubMed - in process]




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