Keyword search (4,163 papers available)

"Sibon I" Authored Publications:

Title Authors PubMed ID
1 Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers. Booij L, Welfeld K, Leyton M, Dagher A, Boileau I, Sibon I, Baker GB, Diksic M, Soucy JP, Pruessner JC, Cawley-Fiset E, Casey KF, Benkelfat C 26905412
PSYCHOLOGY

 

Title:Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers.
Authors:Booij L,  Welfeld K,  Leyton M,  Dagher A,  Boileau I,  Sibon I,  Baker GB,  Diksic M,  Soucy JP,  Pruessner JC,  Cawley-Fiset E,  Casey KF,  Benkelfat C
Link:https://www.ncbi.nlm.nih.gov/pubmed/26905412?dopt=Abstract
Publication:
Keywords:
PMID:26905412 Category:Transl Psychiatry Date Added:2019-05-31
Dept Affiliation: PSYCHOLOGY
1 Department of Psychology, Concordia University, Montreal, QC, Canada.
2 CHU Sainte Justine Hospital Research Center, University of Montreal, Montreal, QC, Canada.
3 Department of Psychiatry, McGill University, Montreal, QC, Canada.
4 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.
5 McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
6 Center for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
7 Pole de Neurosciences Cliniques, Hôpital Pellegrin, CHU Bordeaux, Bordeaux, France.
8 Neurobiology Research Unit, Department of Psychiatry, Institute of Neuroscience and Mental Health, University of Alberta, Edmonton, AB, Canada.
9 Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada.

Description:

Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers.

Transl Psychiatry. 2016 Feb 23;6:e740

Authors: Booij L, Welfeld K, Leyton M, Dagher A, Boileau I, Sibon I, Baker GB, Diksic M, Soucy JP, Pruessner JC, Cawley-Fiset E, Casey KF, Benkelfat C

Abstract

Dysregulation of the stress response system is a potential etiological factor in the development of and relapse to multiple neuropsychiatric disorders. Previously we reported that repeated intermittent d-amphetamine administration can lead to progressively greater dopamine release, thereby providing evidence of drug-induced neurochemical sensitization. Here, we test the hypothesis that repeated exposure to d-amphetamine increases dopaminergic responses to stress; that is, produces cross-sensitization. Using positron emission tomography, we measured in 17 healthy male volunteers (mean ± s.d. = 22.1 ± 3.4 years) [(11)C]raclopride binding responses to a validated psychosocial stress task before and 2 weeks after a regimen of repeated d-amphetamine (3 × 0.3 mg kg(-1), by mouth; n = 8) or placebo (3 × lactose, by mouth; n = 9). Mood and physiological measurements were recorded throughout each session. Before the d-amphetamine regimen, exposure to the stress task increased behavioral and physiological indices of stress (anxiety, heart rate, cortisol, all P ? 0.05). Following the d-amphetamine regimen, the stress-induced cortisol responses were augmented (P < 0.04), and voxel-based analyses showed larger stress-induced decreases in [(11)C]raclopride non-displaceable binding potential across the striatum. In the placebo group, re-exposure to stress led to smaller clusters of decreased [(11)C]raclopride binding, primarily in the sensorimotor striatum (P < 0.05). Together, this study provides evidence for drug × stress cross-sensitization; moreover, random exposure to stimulants and/or stress cumulatively, while enhancing dopamine release in striatal areas, may contribute to a lowered set point for psychopathologies in which altered dopamine neurotransmission is invoked.

PMID: 26905412 [PubMed - indexed for MEDLINE]




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