Keyword search (4,163 papers available)

"Sultana T" Authored Publications:

Title Authors PubMed ID
1 Rosemary essential oil and its components 1,8-cineole and α-pinene induce ROS-dependent lethality and ROS-independent virulence inhibition in Candida albicans Shahina Z; Al Homsi R; Price JDW; Whiteway M; Sultana T; Dahms TES; 36383525
CSFG
2 Metabolic networks of the human gut microbiota. Selber-Hnatiw S, Sultana T, Tse W, Abdollahi N, Abdullah S, Al Rahbani J, Alazar D, Alrumhein NJ, Aprikian S, Arshad R, Azuelos JD, Bernadotte D, Beswick N, Chazbey H, Church K, Ciubotaru E, D'Amato L, Del Corpo T, Deng J, Di Giulio BL, Diveeva D, Elahie E, Frank JGM, Furze E, Garner R, Gibbs V, Goldberg-Hall R, Goldman CJ, Goltsios FF, Gorjipour K, Grant T, Greco B, Guliyev N, Habrich A, Hyland H, Ibrahim N, Iozzo T, Jawaheer-Fenaoui A, Jaworski JJ, Jhajj MK, Jones J, Joyette R, Kaudeer S, Kelley S, Ki 31799915
BIOLOGY
3 Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans. Shahina Z, El-Ganiny AM, Minion J, Whiteway M, Sultana T, Dahms TES 29456868
CHEMBIOCHEM

 

Title:Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans.
Authors:Shahina Z,  El-Ganiny AM,  Minion J,  Whiteway M,  Sultana T,  Dahms TES
Link:https://www.ncbi.nlm.nih.gov/pubmed/29456868?dopt=Abstract
Publication:
Keywords:
PMID:29456868 Category:Fungal Biol Biotechnol Date Added:2019-05-31
Dept Affiliation: CHEMBIOCHEM
1 1Department of Chemistry and Biochemistry, University of Regina, 3737 Wascana Parkway, Regina, SK Canada.
2 2Microbiology and Immunology Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
3 3Regina Qu'Appelle Health Region, Regina, SK Canada.
4 4Centre for Structural and Functional Genomics, Concordia University, Montreal, QC Canada.

Description:

Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans.

Fungal Biol Biotechnol. 2018;5:3

Authors: Shahina Z, El-Ganiny AM, Minion J, Whiteway M, Sultana T, Dahms TES

Abstract

Background: Cinnamon (Cinnamomum zeylanicum) bark extract exhibits potent inhibitory activity against Candida albicans but the antifungal mechanisms of this essential oil remain largely unexplored.

Results: We analyzed the impact of cinnamon bark oil on C. albicans RSY150, and clinical strains isolated from patients with candidemia and candidiasis. The viability of RSY150 was significantly compromised in a dose dependent manner when exposed to cinnamon bark oil, with extensive cell surface remodelling at sub inhibitory levels (62.5 µg/mL). Atomic force microscopy revealed cell surface exfoliation, altered ultrastructure and reduced cell wall integrity for both RSY150 and clinical isolates exposed to cinnamon bark oil. Cell wall damage induced by cinnamon bark oil was confirmed by exposure to stressors and the sensitivity of cell wall mutants involved in cell wall organization, biogenesis, and morphogenesis. The essential oil triggered cell cycle arrest by disrupting beta tubulin distribution, which led to mitotic spindle defects, ultimately compromising the cell membrane and allowing leakage of cellular components. The multiple targets of cinnamon bark oil can be attributed to its components, including cinnamaldehyde (74%), and minor components (< 6%) such as linalool (3.9%), cinamyl acetate (3.8%), a-caryophyllene (5.3%) and limonene (2%). Complete inhibition of the mitotic spindle assembly was observed in C. albicans treated with cinnamaldehyde at MIC (112 µg/mL).

Conclusions: Since cinnamaldehyde disrupts both the cell wall and tubulin polymerization, it may serve as an effective antifungal, either by chemical modification to improve its specificity and efficacy or in combination with other antifungal drugs.

PMID: 29456868 [PubMed]




BookR developed by Sriram Narayanan
for the Concordia University School of Health
Copyright © 2011-2026
Cookie settings
Concordia University