PERFORM Publications

Keyword search (4,164 papers available)

Title		Authors	PubMed ID
1	DNA methylation in people with Anorexia Nervosa: Epigenome-wide patterns in actively ill, long-term remitted, and healthy-eater women	Steiger H; Booij L; Thaler L; St-Hilaire A; Israël M; Casey KF; Oliverio S; Crescenzi O; Lee V; Turecki G; Joober R; Szyf M; Breton É;	35703085 PSYCHOLOGY
2	DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents.	Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L	32479312 PSYCHOLOGY
3	Peripheral DNA methylation of HPA axis-related genes in humans: Cross-tissue convergence, two-year stability and behavioural and neural correlates.	Di Sante J, Ismaylova E, Nemoda Z, Gouin JP, Yu WJ, Caldwell W, Vitaro F, Szyf M, Tremblay RE, Booij L	30059826 PSYCHOLOGY
4	Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins.	Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L	28032437 PSYCHOLOGY
5	Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity.	Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L	28774705 PSYCHOLOGY
6	Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression.	Tozzi L, Farrell C, Booij L, Doolin K, Nemoda Z, Szyf M, Pomares FB, Chiarella J, O'Keane V, Frodl T	29182159 PSYCHOLOGY
7	Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins.	Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L	30089832 PSYCHOLOGY
8	A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women	Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E	30693739 PSYCHOLOGY
9	DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic-pituitary-adrenal axis activity and to early life emotional abuse.	Farrell C, Doolin K, O' Leary N, Jairaj C, Roddy D, Tozzi L, Morris D, Harkin A, Frodl T, Nemoda Z, Szyf M, Booij L, O'Keane V	29793048 PSYCHOLOGY

Title:	DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents.
Authors:	Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L
Link:	https://www.ncbi.nlm.nih.gov/pubmed/32479312?dopt=Abstract
DOI:	10.1016/j.jad.2020.03.062
Publication:	Journal of affective disorders
Keywords:	Adolescent depression; Brain structure; DNA methylation; Epigenetics; Functional connectivity;
PMID:	32479312	Category:	J Affect Disord	Date Added:	2020-06-02
Dept Affiliation:	PSYCHOLOGY 1 Department of Psychology, Concordia University, Montreal, Canada; CHU Sainte-Justine Hospital Research Centre, University of Montreal, Montreal, Canada; Department of Psychology, Queen's University, Kingston, Canada. 2 Department of Psychology, Queen's University, Kingston, Canada. 3 Department of Psychology, Concordia University, Montreal, Canada. 4 Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany. 5 Department of Psychiatry, Trinity College School of Medicine and Trinity College Institute of Neuroscience, Dublin, Ireland. 6 Department of Psychology, Concordia University, Montreal, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada; Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary. 7 Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada. 8 Department of Psychiatry, Division of Child Psychiatry, Hotel Dieu Hospital, Queen's University, Kingston, Canada. 9 Department of Psychology, Concordia University, Montreal, Canada; CHU Sainte-Justine Hospital Research Centre, University of Montreal, Montreal, Canada; Department of Psychology, Queen's University, Kingston, Canada. Electronic address: linda.booij@concordia.ca.

Description:

DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents.

J Affect Disord. 2020 Jun 15;271:160-168

Authors: Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L

Abstract

BACKGROUND: Studies in adult depressed patients have indicated that altered DNA methylation patterns at genes related to serotonin and HPA axis functioning (e.g., SLC6A4, FKBP5) are associated with changes in frontolimbic functional connectivity and structure. Here, we examined whether these associations can be generalized to adolescents.

METHODS: 25 adolescents with depression (Mean age = 15.72 ± 0.94 SD; 20 girls) and 20 healthy controls (Mean age = 16.05 ± 1.5 SD; 16 girls) underwent a functional and structural magnetic resonance imaging protocol, which included a resting-state assessment and measures of brain morphometry. DNA was obtained from saliva. Levels of SLC6A4 and FKBP5 methylation were determined using pyrosequencing.

RESULTS: SLC6A4 methylation was linked to amygdala-frontal operculum resting-state functional connectivity (rs-FC), regardless of diagnosis, and was differentially associated with inferior orbitofrontal gyrus (IFOG) gray matter (GM) volume in adolescents with depression and controls. Replicating and extending previous findings in adults, FKBP5 methylation was associated with IFOG GM volume in depressed and healthy adolescents, as well as orbitofrontal cortex (OFC)-rostral prefrontal cortex (RPFC) connectivity in healthy adolescents only.

LIMITATIONS: Effects of medication use or genotype cannot be ruled out. Further, the relatively small sample size and predominately female sample may limit generalizability.

CONCLUSIONS: These findings suggest that previously observed associations between SLC6A4 and FKBP5 methylation and frontolimbic processes in adult depressed patients can be in part generalized to adolescent patients. Further, findings suggest that measuring peripheral methylation at these genes deserves further attention as potential markers of typical and atypical development.

PMID: 32479312 [PubMed - as supplied by publisher]

BookR: School of Health Core Facilities Booking

"Szyf M" Authored Publications:

Search Publications

No results