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PubMed Publications| Keyword search (4,164 papers available) |  |
"Tremblay SA" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease | Sanami S; Tremblay SA; Potvin-Jutras Z; Rezaei A; Sabra D; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41680492 SOH |
| 2 | Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults | Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41543005 SOH |
| 3 | The Impact of Coronary Artery Disease on Brain Vascular and Metabolic Health: Links to Cognitive Function | Sanami S; Tremblay SA; Rezaei A; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41452711 SOH |
| 4 | Multivariate white matter microstructure alterations in older adults with coronary artery disease | Tremblay SA; Potvin-Jutras Z; Sabra D; Rezaei A; Sanami S; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Leppert IR; Tardif CL; Steele CJ; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 40829939 SOH |
| 5 | Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer s disease | Tremblay SA; Nathan Spreng R; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ; | 40086421 PSYCHOLOGY |
| 6 | Alzheimer's Imaging Consortium | Tremblay SA; Spreng RN; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ; | 39782998 CONCORDIA |
| 7 | Biomarkers | Tremblay SA; Spreng RN; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ; | 39785351 CONCORDIA |
| 8 | Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status | Wearn A; Tremblay SA; Tardif CL; Leppert IR; Gauthier CJ; Baracchini G; Hughes C; Hewan P; Tremblay-Mercier J; Rosa-Neto P; Poirier J; Villeneuve S; Schmitz TW; Turner GR; Spreng RN; | 38830849 SOH |
| 9 | MVComp toolbox: MultiVariate Comparisons of brain MRI features accounting for common information across metrics | Tremblay SA; Alasmar Z; Pirhadi A; Carbonell F; Iturria-Medina Y; Gauthier CJ; Steele CJ; | 38463982 SOH |
| 10 | Motor sequences; separating the sequence from the motor. A longitudinal rsfMRI study | Jäger AP; Huntenburg JM; Tremblay SA; Schneider U; Grahl S; Huck J; Tardif CL; Villringer A; Gauthier CJ; Bazin PL; Steele CJ; | 34704176 PERFORM |
| 11 | White matter microstructural changes in short-term learning of a continuous visuomotor sequence | Tremblay SA; Jäger AT; Huck J; Giacosa C; Beram S; Schneider U; Grahl S; Villringer A; Tardif CL; Bazin PL; Steele CJ; Gauthier CJ; | 33885965 PERFORM |
| 12 | State-Dependent Entrainment of Prefrontal Cortex Local Field Potential Activity Following Patterned Stimulation of the Cerebellar Vermis. | Tremblay SA, Chapman CA, Courtemanche R | 31736718 HKAP |
| Title: | Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease | ||||
| Authors: | Sanami S, Tremblay SA, Potvin-Jutras Z, Rezaei A, Sabra D, Gagnon C, Intzandt B, Mainville-Berthiaume A, Wright L, Gayda M, Iglesies-Grau J, Nigam A, Bherer L, Gauthier CJ | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41680492/ | ||||
| DOI: | 10.1007/s11357-026-02128-8 | ||||
| Publication: | GeroScience | ||||
| Keywords: | Cardiorespiratory fitness; Cerebral blood flow; Cerebral metabolic rate of oxygen; Cerebrovascular reactivity; Coronary artery disease; Oxygen extraction fraction; | ||||
| PMID: | 41680492 | Category: | Date Added: | 2026-02-13 | |
| Dept Affiliation: |
SOH
1 Physics Department, Concordia University, SP Building, Room 367.067141 Sherbrooke St. W, Montreal, QC, H4B 1R6, Canada. 2 Centre EPIC and Research Center, Montreal Heart Institute, Montreal, QC, H1T 1N6, Canada. 3 School of Health, Concordia University, Montreal, QC, H4B 1R6, Canada. 4 Department of Biomedical Science, Faculty of Medicine, Université de Montreal, Montreal, QC, H2V 0B3, Canada. 5 Kinesiology & Health Science, Faculty of Health, York University, Toronto, ON, M3J 1P3, Canada. 6 Dr Sandra Black Centre for Brain Resilience and Recovery, Sunnybrook Research Institute, Toronto, ON, M4N 3M5, Canada. 7 Department of Psychology, Concordia University, Montreal, QC, H4B 1R6, Canada. 8 Department of Medicine, Université de Montreal, Montreal, QC, H2V 0B3, Canada. 9 Department of Nutrition, Université de Montréal, Montreal, QC, H2V 0B3, Canada. 10 Research Center, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, H3W 1W5, Canada. 11 Physics Department, Concordia University, SP Building, Room 367.067141 Sherbrooke St. W, Montreal, QC, H4B 1R6, Canada. claudine.gauthier@concordia.ca. 12 Centre EPIC and Research Center, Montreal Heart Institute, Montreal, QC, H1T 1N6, Canada. claudine.gauthier@concordia.ca. 13 School of Health, Concordia University, Montreal, QC, H4B 1R6, Canada. claudine.gauthier@concordia.ca. |
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Description: |
This study investigated whether higher cardiorespiratory fitness (VO2peak) is associated with better cerebral vascular and metabolic health-specifically cerebral blood flow (CBF), cerebrovascular reactivity (CVR), cerebral metabolic rate of oxygen (CMRO2), and oxygen extraction fraction (OEF) across healthy older adults and patients with coronary artery disease (CAD). Thirty-seven healthy adults (65.3 ± 8.3 years old) and 35 CAD patients (66.4 ± 9.3 years old) underwent calibrated fMRI using hypercapnic and hyperoxic gas challenges (including carbogen) to quantify gray matter CBF, CVR, CMRO2, and OEF. VO2peak was obtained from a maximal cycle ergometer cardiopulmonary exercise test. Associations between VO2peak and brain biomarkers were evaluated with group terms to test CAD-specific effects. Across all participants, VO2peak was positively associated with CBF (ß = 0.32, p = 0.02) and CVR (ß = 0.002, p = 0.04) in gray matter, indicating an association between aerobic fitness and vascular health. Metabolic effects differed by group: in CAD patients, VO2peak correlated positively with CMRO2 (ß = 0.08, p = 0.02), suggesting higher fitness may be associated with preserved oxidative metabolism, while in healthy controls, VO2peak was negatively associated with OEF (ß = -3.6, p = 0.02), consistent with aging-related adaptations driven by improved CBF without CMRO2 changes. VO2peak is positively associated with cerebral vascular function in older adults and shows group-specific metabolic benefits: in CAD, higher VO2peak relates to preserved CMRO2, whereas in healthy individuals it is linked primarily to enhanced perfusion and reduced extraction. These findings support aerobic exercise as a promising strategy to mitigate CAD-related brain alterations and highlight VO2peak as a potentially modifiable target for prevention and rehabilitation. |
