Keyword search (4,164 papers available)

"Trujillo-Pisanty I" Authored Publications:

Title Authors PubMed ID
1 Does phasic dopamine release cause policy updates? Carter F; Cossette MP; Trujillo-Pisanty I; Pallikaras V; Breton YA; Conover K; Caplan J; Solis P; Voisard J; Yaksich A; Shizgal P; 38039083
PSYCHOLOGY
2 Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts. Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N 32724058
PSYCHOLOGY
3 Dopamine neurons do not constitute an obligatory stage in the final common path for the evaluation and pursuit of brain stimulation reward. Trujillo-Pisanty I, Conover K, Solis P, Palacios D, Shizgal P 32502210
CSBN
4 Robust optical fiber patch-cords for in vivo optogenetic experiments in rats. Trujillo-Pisanty I, Sanio C, Chaudhri N, Shizgal P 26150997
CSBN
5 The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations. Scardochio T, Trujillo-Pisanty I, Conover K, Shizgal P, Clarke PB 26696851
CSBN

 

Title:Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts.
Authors:Valyear MD,  Glovaci I,  Zaari A,  Lahlou S,  Trujillo-Pisanty I,  Andrew Chapman C,  Chaudhri N
Link:https://www.ncbi.nlm.nih.gov/pubmed/32724058
DOI:10.1038/s41467-020-17543-4
Publication:Nature communications
Keywords:
PMID:32724058 Category:Nat Commun Date Added:2020-07-30
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada.
2 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada. nadia.chaudhri@concordia.ca.

Description:

Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts.

Nat Commun. 2020 Jul 28;11(1):3764

Authors: Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N

Abstract

Context can influence reactions to environmental cues and this elemental process has implications for substance use disorder. Using an animal model, we show that an alcohol-associated context elevates entry into a fluid port triggered by a conditioned stimulus (CS) that predicted alcohol (CS-triggered alcohol-seeking). This effect persists across multiple sessions and, after it diminishes in extinction, the alcohol context retains the capacity to augment reinstatement. Systemically administered eticlopride and chemogenetic inhibition of ventral tegmental area (VTA) dopamine neurons reduce CS-triggered alcohol-seeking. Chemogenetically silencing VTA dopamine terminals in the nucleus accumbens (NAc) core reduces CS-triggered alcohol-seeking, irrespective of context, whereas silencing VTA dopamine terminals in the NAc shell selectively reduces the elevation of CS-triggered alcohol-seeking in an alcohol context. This dissociation reveals new roles for divergent mesolimbic dopamine circuits in the control of responding to a discrete cue for alcohol and in the amplification of this behaviour in an alcohol context.

PMID: 32724058 [PubMed - as supplied by publisher]




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