Keyword search (4,164 papers available)

"Valyear MD" Authored Publications:

Title Authors PubMed ID
1 Palatability attributed to alcohol and alcohol-paired flavors Valyear MD; Eustachon NM; Britt JP; 38430645
CSBN
2 Augmenting glutamatergic, but not dopaminergic, activity in the nucleus accumbens shell disrupts responding to a discrete alcohol cue in an alcohol context Valyear MD; Brown A; Deyab G; Villaruel FR; Lahlou S; Caporicci-Dinucci N; Chaudhri N; 38185906
PSYCHOLOGY
3 A new circuit underlying the renewal of appetitive Pavlovian responses: Commentary on Brown and Chaudhri (2022) Valyear MD; Britt JP; 36700576
CSBN
4 Learning processes in relapse to alcohol use: lessons from animal models Valyear MD; LeCocq MR; Brown A; Villaruel FR; Segal D; Chaudhri N; 36264342
PSYCHOLOGY
5 Supplementary dataset of context-dependent conditioned responding to an alcohol-predictive cue in female and male rats Segal D; Valyear MD; Chaudhri N; 35330738
PSYCHOLOGY
6 The role of context on responding to an alcohol-predictive cue in female and male rats Segal D; Valyear MD; Chaudhri N; 34742865
PSYCHOLOGY
7 Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts. Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N 32724058
PSYCHOLOGY
8 Context controls the timing of responses to an alcohol-predictive conditioned stimulus. Valyear MD, Chaudhri N 32017964
PSYCHOLOGY
9 Alcohol-seeking and relapse: A focus on incentive salience and contextual conditioning. Valyear MD, Villaruel FR, Chaudhri N 28473252
PSYCHOLOGY

 

Title:Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts.
Authors:Valyear MD,  Glovaci I,  Zaari A,  Lahlou S,  Trujillo-Pisanty I,  Andrew Chapman C,  Chaudhri N
Link:https://www.ncbi.nlm.nih.gov/pubmed/32724058
DOI:10.1038/s41467-020-17543-4
Publication:Nature communications
Keywords:
PMID:32724058 Category:Nat Commun Date Added:2020-07-30
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada.
2 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada. nadia.chaudhri@concordia.ca.

Description:

Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts.

Nat Commun. 2020 Jul 28;11(1):3764

Authors: Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N

Abstract

Context can influence reactions to environmental cues and this elemental process has implications for substance use disorder. Using an animal model, we show that an alcohol-associated context elevates entry into a fluid port triggered by a conditioned stimulus (CS) that predicted alcohol (CS-triggered alcohol-seeking). This effect persists across multiple sessions and, after it diminishes in extinction, the alcohol context retains the capacity to augment reinstatement. Systemically administered eticlopride and chemogenetic inhibition of ventral tegmental area (VTA) dopamine neurons reduce CS-triggered alcohol-seeking. Chemogenetically silencing VTA dopamine terminals in the nucleus accumbens (NAc) core reduces CS-triggered alcohol-seeking, irrespective of context, whereas silencing VTA dopamine terminals in the NAc shell selectively reduces the elevation of CS-triggered alcohol-seeking in an alcohol context. This dissociation reveals new roles for divergent mesolimbic dopamine circuits in the control of responding to a discrete cue for alcohol and in the amplification of this behaviour in an alcohol context.

PMID: 32724058 [PubMed - as supplied by publisher]




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