Keyword search (4,163 papers available)

"Villringer A" Authored Publications:

Title Authors PubMed ID
1 Patterns of Structural Disconnection Driving Proprioceptive Deficits in Chronic Stroke Kaeja M; Gajiyeva L; Iturria-Medina Y; Villringer A; Sehm B; Steele C; 41392885
SOH
2 Decreased long-range temporal correlations in the resting-state functional magnetic resonance imaging blood-oxygen-level-dependent signal reflect motor sequence learning up to 2 weeks following training Jäger AP; Bailey A; Huntenburg JM; Tardif CL; Villringer A; Gauthier CJ; Nikulin V; Bazin PL; Steele CJ; 38124341
SOH
3 The impact of lesion side on bilateral upper limb coordination after stroke Shih PC; Steele CJ; Hoepfel D; Muffel T; Villringer A; Sehm B; 38093308
PSYCHOLOGY
4 Modeling venous bias in resting state functional MRI metrics Huck J; Jäger AT; Schneider U; Grahl S; Fan AP; Tardif C; Villringer A; Bazin PL; Steele CJ; Gauthier CJ; 37498014
PERFORM
5 Visuo-motor transformations in the intraparietal sulcus mediate the acquisition of endovascular medical skill Paul KI; Mueller K; Rousseau PN; Glathe A; Taatgen NA; Cnossen F; Lanzer P; Villringer A; Steele CJ; 36529202
PSYCHOLOGY
6 Mental rotation ability predicts the acquisition of basic endovascular skills Paul KI; Glathe A; Taatgen NA; Steele CJ; Villringer A; Lanzer P; Cnossen F; 34789742
PSYCHOLOGY
7 Motor sequences; separating the sequence from the motor. A longitudinal rsfMRI study Jäger AP; Huntenburg JM; Tremblay SA; Schneider U; Grahl S; Huck J; Tardif CL; Villringer A; Gauthier CJ; Bazin PL; Steele CJ; 34704176
PERFORM
8 Alpha and beta neural oscillations differentially reflect age-related differences in bilateral coordination Shih PC; Steele CJ; Nikulin VV; Gundlach C; Kruse J; Villringer A; Sehm B; 33979705
PSYCHOLOGY
9 White matter microstructural changes in short-term learning of a continuous visuomotor sequence Tremblay SA; Jäger AT; Huck J; Giacosa C; Beram S; Schneider U; Grahl S; Villringer A; Tardif CL; Bazin PL; Steele CJ; Gauthier CJ; 33885965
PERFORM
10 Modulation of premotor cortex response to sequence motor learning during escitalopram intake. Molloy EN; Mueller K; Beinhölzl N; Blöchl M; Piecha FA; Pampel A; Steele CJ; Scharrer U; Zheleva G; Regenthal R; Sehm B; Nikulin VV; Möller HE; Villringer A; Sacher J; 33148103
PSYCHOLOGY
11 High resolution atlas of the venous brain vasculature from 7 T quantitative susceptibility maps. Huck J, Wanner Y, Fan AP, Jäger AT, Grahl S, Schneider U, Villringer A, Steele CJ, Tardif CL, Bazin PL, Gauthier CJ 31278570
PSYCHOLOGY
12 Advanced MRI techniques to improve our understanding of experience-induced neuroplasticity. Tardif CL, Gauthier CJ, Steele CJ, Bazin PL, Schäfer A, Schaefer A, Turner R, Villringer A 26318050
PERFORM
13 Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke. Fan AP, Khalil AA, Fiebach JB, Zaharchuk G, Villringer A, Villringer K, Gauthier CJ 30732551
PHYSICS
14 Kinematic profiles suggest differential control processes involved in bilateral in-phase and anti-phase movements. Shih PC, Steele CJ, Nikulin V, Villringer A, Sehm B 30824858
PSYCHOLOGY
15 Investigation of the confounding effects of vasculature and metabolism on computational anatomy studies. Tardif CL, Steele CJ, Lampe L, Bazin PL, Ragert P, Villringer A, Gauthier CJ 28159689
PERFORM

 

Title:Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke.
Authors:Fan APKhalil AAFiebach JBZaharchuk GVillringer AVillringer KGauthier CJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/30732551?dopt=Abstract
Publication:
Keywords:
PMID:30732551 Category:J Cereb Blood Flow Metab Date Added:2019-06-04
Dept Affiliation: PHYSICS
1 Department of Radiology, Stanford University, Stanford, CA, USA.
2 Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany.
3 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
4 Berlin School of Mind and Brain, Humboldt-Universitaet zu Berlin, Berlin, Germany.
5 Department of Physics, Concordia University, Montreal, Canada.
6 Montreal Heart Institute, Montreal, Canada.

Description:

Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke.

J Cereb Blood Flow Metab. 2019 Feb 07;:271678X19827944

Authors: Fan AP, Khalil AA, Fiebach JB, Zaharchuk G, Villringer A, Villringer K, Gauthier CJ

Abstract

Recent clinical trials of new revascularization therapies in acute ischemic stroke have highlighted the importance of physiological imaging to identify optimal treatments for patients. Oxygen extraction fraction (OEF) is a hallmark of at-risk tissue in stroke, and can be quantified from the susceptibility effect of deoxyhemoglobin molecules in venous blood on MRI phase scans. We measured OEF within cerebral veins using advanced quantitative susceptibility mapping (QSM) MRI reconstructions in 20 acute stroke patients. Absolute OEF was elevated in the affected (29.3?±?3.4%) versus the contralateral hemisphere (25.5?±?3.1%) of patients with large diffusion-perfusion lesion mismatch ( P?=?0.032). In these patients, OEF negatively correlated with relative CBF measured by dynamic susceptibility contrast MRI ( P?=?0.004), suggesting compensation for reduced flow. Patients with perfusion-diffusion match or no hypo-perfusion showed less OEF difference between hemispheres. Nine patients received longitudinal assessment and showed OEF ratio (affected to contralateral) of 1.2?±?0.1 at baseline that normalized (decreased) to 1.0?±?0.1 at follow-up three days later ( P?=?0.03). Our feasibility study demonstrates that QSM MRI can non-invasively quantify OEF in stroke patients, relates to perfusion status, and is sensitive to OEF changes over time. Clinical trial registration: Longitudinal MRI examinations of patients with brain ischemia and blood brain barrier permeability; clinicaltrials.org : NCT02077582.

PMID: 30732551 [PubMed - as supplied by publisher]





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