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PubMed Publications| Keyword search (4,163 papers available) |  |
"Vu TT" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Strengthening and Targeted Rehabilitation for Optimal Neuromuscular Gains for chronic BACK pain (STRONG-BACK): protocol for a randomised controlled trial in participants with primary nociceptive pain drivers | Fortin M; Rosenstein B; Bertrand C; Vaillancourt N; Wright A; Montpetit C; Macedo L; Elliott J; Cook CE; Tousignant-Laflamme Y; Ma J; Pagé MG; Dover G; Dang-Vu TT; Weber MH; | 41876162 SOH |
| 2 | The effectiveness of Cognitive behavioral therapy for insomnia on sleep EEG hyperarousal: a multicentric polysomnographic study | Sforza M; Morin CM; Dang-Vu TT; Pomares FB; Perrault AA; Gouin JP; Bušková J; Janku K; Vgontzas A; Fernandez-Mendoza J; Bastien CH; Riemann D; Baglioni C; Carollo G; Casoni F; Zucconi M; Castronovo V; Galbiati A; Ferini-Strambi L; | 41688421 SOH |
| 3 | Obstructive Sleep Apnea Risk and Mental Health Conditions Among Older Canadian Adults in the Canadian Longitudinal Study on Aging | Kendzerska T; Mallick R; Li W; Robillard R; Taler V; Webber C; Saymeh M; Dang-Vu TT; Tanuseputro P; Fiedorowicz JG; | 41632160 HKAP |
| 4 | Sleep spindles and slow oscillations predict neurofilament‐light, neurogranin 36, Chitinase‐3‐like protein‐1 and cognition in mild to moderate Alzheimer's Disease | Paez A; Dogaheh SB; Gillman SO; Carnes A; Dakterzada F; Barbe F; Piñol-Ripoll G; Dang-Vu TT; | 41512123 CONCORDIA |
| 5 | The interplay between orexin, neurodegeneration, cognition and sleep microarchitecture in mild to moderate Alzheimer's Disease | Paez A; Piñol-Ripoll G; Dogaheh SB; Gillman SO; Dakterzada F; Carnes A; Barbe F; Dang-Vu TT; | 41512277 CONCORDIA |
| 6 | Drug Development | Cunningham NP; Tremblay-Mercier J; Baril AA; Dang-Vu TT; Lim A; Geddes MR; Badawy M; Poirier J; Ducharme S; Villeneuve S; | 41450269 CONCORDIA |
| 7 | Public Health | Gurve D; Centen AP; Slack PJ; Dang-Vu TT; Belleville S; Anderson ND; Montero-Odasso M; Nygaard HB; Chertkow H; Feldman HH; Brewster PWH; Lim A; | 41434309 PERFORM |
| 8 | Effects of cognitive-behavioral therapy for insomnia during sedative-hypnotics withdrawal on sleep and cognition in older adults | Barbaux L; Cross NE; Perrault AA; Es-Sounni M; Desrosiers C; Clerc D; Andriamampionona F; Lussier D; Tannenbaum C; Guimond A; Grenier S; Gouin JP; Dang-Vu TT; | 41092866 SOH |
| 9 | Identification of five sleep-biopsychosocial profiles with specific neural signatures linking sleep variability with health, cognition, and lifestyle factors | Perrault AA; Kebets V; Kuek NMY; Cross NE; Tesfaye R; Pomares FB; Li J; Chee MWL; Dang-Vu TT; Yeo BTT; | 41056215 HKAP |
| 10 | The complex association between bedtime screen use and adult sleep health | Vézina-Im LA; Morin CM; Chen S; Ivers H; Carney CE; Chaput JP; Dang-Vu TT; Davidson JR; Robillard R; | 40713469 HKAP |
| 11 | Effect of a single dose of lorazepam on resting state functional connectivity in healthy adults | Ferland MC; Wang R; Therrien-Blanchet JM; Remahi S; Côté S; Fréchette AJ; Dang-Vu TT; Liu H; Lepage JF; Théoret H; | 40646404 PERFORM |
| 12 | Effect of chronic benzodiazepine and benzodiazepine receptor agonist use on sleep architecture and brain oscillations in older adults with chronic insomnia | Barbaux L; Perrault AA; Cross NE; Weiner OM; Es-Sounni M; Pomares FB; Tarelli L; McCarthy M; Maltezos A; Smith D; Gong K; O' Byrne J; Yue V; Desrosiers C; Clerc D; Andriamampionona F; Lussier D; Gilbert S; Tannenbaum C; Gouin JP; Dang-Vu TT; | 40570297 CSBN |
| 13 | Efficacy of cognitive behavioral therapy for insomnia and lemborexant medication for different subtypes of chronic insomnia: study protocol for a randomized controlled trial | Chen SJ; Ivers H; Dang-Vu TT; Shapiro CM; Carney CE; Robillard R; Morin CM; | 40346496 HKAP |
| 14 | Phase-Amplitude Coupling of NREM Sleep Oscillations Shows Between-Night Stability and is Related to Overnight Memory Gains | Cross N; O' Byrne J; Weiner OM; Giraud J; Perrault AA; Dang-Vu TT; | 40214027 PERFORM |
| 15 | Mirtazapine for chronic insomnia in older adults: a randomised double-blind placebo-controlled trial-the MIRAGE study | Nguyen PV; Dang-Vu TT; Forest G; Desjardins S; Forget MF; Vu TT; Nguyen QD; Kouassi E; Desmarais P; | 40135470 HKAP |
| 16 | Sleep neuroimaging: Review and future directions | Pereira M; Chen X; Paltarzhytskaya A; Pache?o Y; Muller N; Bovy L; Lei X; Chen W; Ren H; Song C; Lewis LD; Dang-Vu TT; Czisch M; Picchioni D; Duyn J; Peigneux P; Tagliazucchi E; Dresler M; | 39940102 HKAP |
| 17 | Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease | Páez A; Gillman SO; Dogaheh SB; Carnes A; Dakterzada F; Barbé F; Dang-Vu TT; Ripoll GP; | 39878233 CONCORDIA |
| 18 | Cognitive-behavioural therapy for insomnia mechanism of action: Exploring the homeostatic K-complex involvement | Sforza M; Morin CM; Dang-Vu TT; Pomares FB; Perrault AA; Gouin JP; Bušková J; Janku K; Vgontzas A; Fernandez-Mendoza J; Bastien CH; Riemann D; Baglioni C; Carollo G; Casoni F; Zucconi M; Castronovo V; Galbiati A; Ferini-Strambi L; | 39739397 SOH |
| 19 | Trends in nighttime insomnia symptoms in Canada from 2007 to 2021 | Chaput JP; Morin CM; Robillard R; Carney CE; Dang-Vu TT; Davidson JR; Tomkinson GR; Lang JJ; | 39556998 HKAP |
| 20 | Delphi consensus recommendations for the management of chronic insomnia in Canada | Morin CM; Khullar A; Robillard R; Desautels A; Mak MSB; Dang-Vu TT; Chow W; Habert J; Lessard S; Alima L; Ayas NT; MacFarlane J; Kendzerska T; Lee EK; Carney CE; | 39481275 HKAP |
| 21 | Prevalence of insomnia and use of sleep aids among adults in Canada | Morin CM; Vézina-Im LA; Chen SJ; Ivers H; Carney CE; Chaput JP; Dang-Vu TT; Davidson JR; Belleville G; Lorrain D; Horn O; Robillard R; | 39369578 HKAP |
| 22 | Efficacy and safety of insomnia treatment with lemborexant in older adults: analyses from three clinical trials | Gotfried MH; Auerbach SH; Dang-Vu TT; Mishima K; Kumar D; Moline M; Malhotra M; | 39120786 HKAP |
| 23 | NREM sleep brain networks modulate cognitive recovery from sleep deprivation | Lee K; Wang Y; Cross NE; Jegou A; Razavipour F; Pomares FB; Perrault AA; Nguyen A; Aydin Ü; Uji M; Abdallah C; Anticevic A; Frauscher B; Benali H; Dang-Vu TT; Grova C; | 39005401 PERFORM |
| 24 | Predicting response to stepped-care cognitive behavioral therapy for insomnia using pre-treatment heart rate variability in cancer patients | Garneau J; Savard J; Dang-Vu TT; Gouin JP; | 38991424 HKAP |
| 25 | Sleep spindles predict stress-related increases in sleep disturbances | Dang-Vu TT; Salimi A; Boucetta S; Wenzel K; O' Byrne J; Brandewinder M; Berthomier C; Gouin JP; | 25713529 PERFORM |
| 26 | High-frequency heart rate variability during worry predicts stress-related increases in sleep disturbances | Gouin JP; Wenzel K; Boucetta S; O' Byrne J; Salimi A; Dang-Vu TT; | 25819418 PERFORM |
| 27 | Efficacy of Lemborexant in Adults ≥ 65 Years of Age with Insomnia Disorder | Arnold V; Ancoli-Israel S; Dang-Vu TT; Mishima K; Pinner K; Malhotra M; Moline M; | 38748321 HKAP |
| 28 | A multidimensional investigation of sleep and biopsychosocial profiles with associated neural signatures | Perrault AA; Kebets V; Kuek NMY; Cross NE; Tesfaye R; Pomares FB; Li J; Chee MWL; Dang-Vu TT; Yeo BTT; | 38659875 HKAP |
| 29 | A Pilot Randomized Trial of Combined Cognitive-Behavioral Therapy and Exercise Training Versus Exercise Training Alone for the Management of Chronic Insomnia in Obstructive Sleep Apnea | Cammalleri A; Perrault AA; Hillcoat A; Carrese-Chacra E; Tarelli L; Patel R; Baltzan M; Chouchou F; Dang-Vu TT; Gouin JP; Pepin V; | 38663849 PERFORM |
| 30 | A multidimensional investigation of sleep and biopsychosocialprofiles with associated neural signatures | Perrault AA; Kebets V; Kuek NMY; Cross NE; Tesfaye R; Pomares FB; Li J; Chee MWL; Dang-Vu TT; Thomas Yeo BT; | 38559143 HKAP |
| 31 | Methodological approach to sleep state misperception in insomnia disorder: Comparison between multiple nights of actigraphy recordings and a single night of polysomnography recording | Maltezos A; Perrault AA; Walsh NA; Phillips EM; Gong K; Tarelli L; Smith D; Cross NE; Pomares FB; Gouin JP; Dang-Vu TT; | 38325157 HKAP |
| 32 | White matter integrity in narcolepsy: the structural blueprint for functional complaints? | Gool JK; Dang-Vu TT; van der Werf YD; | 38263318 HKAP |
| 33 | Factors influencing older adults' participation in telehealth interventions for primary prevention and health promotion: A rapid review | Turcotte S; Bouchard C; Rousseau J; DeBroux Leduc R; Bier N; Kairy D; Dang-Vu TT; Sarimanukoglu K; Dubé F; Bourgeois Racine C; Rioux C; Shea C; Filiatrault J; | 38014903 CONCORDIA |
| 34 | The effects of acute exercise and a nap on heart rate variability and memory in young sedentary adults | Mograss M; Frimpong E; Vilcourt F; Chouchou F; Zvionow T; Dang-Vu TT; | 37855092 PERFORM |
| 35 | Insomnia symptoms among older adults during the first year of the COVID-19 pandemic: A longitudinal study | Gong K; Garneau J; Grenier S; Vasiliadis HM; Dang-Vu TT; Dialahy IZ; Gouin JP; | 37380593 HKAP |
| 36 | Respiratory sinus arrhythmia moderates the interpersonal consequences of brooding rumination | Caldwell W; MacNeil S; Wrosch C; McGrath JJ; Dang-Vu TT; Morin AJS; Gouin JP; | 36844897 HKAP |
| 37 | Trajectories of psychological distress during the COVID-19 pandemic among community-dwelling older adults in Quebec: A longitudinal study | Matovic S; Grenier S; Jauvin F; Gravel C; Vasiliadis HM; Vasil N; Belleville S; Rainville P; Dang-Vu TT; Aubertin-Leheudre M; Knäuper B; Dialahy IZ; Gouin JP; | 36703303 HKAP |
| 38 | Online physical exercise intervention in older adults during lockdown: Can we improve the recipe? | Granet J; Peyrusqué E; Ruiz F; Buckinx F; Abdelkader LB; Dang-Vu TT; Sirois MJ; Gouin JP; Pageaux B; Aubertin-Leheudre M; | 36635450 PERFORM |
| 39 | Economic burden of insomnia symptoms in Canada | Chaput JP; Janssen I; Sampasa-Kanyinga H; Carney CE; Dang-Vu TT; Davidson JR; Robillard R; Morin CM; | 36319579 PERFORM |
| 40 | Insomnia disorder increases the risk of subjective memory decline in middle-aged and older adults: a longitudinal analysis of the Canadian Longitudinal Study on Aging | Zhao JL; Cross N; Yao CW; Carrier J; Postuma RB; Gosselin N; Kakinami L; Dang-Vu TT; | 35877203 PERFORM |
| 41 | Effects of cognitive behavioral therapy for insomnia on subjective and objective measures of sleep and cognition | Perrault AA; Pomares FB; Smith D; Cross NE; Gong K; Maltezos A; McCarthy M; Madigan E; Tarelli L; McGrath JJ; Savard J; Schwartz S; Gouin JP; Dang-Vu TT; | 35691208 PERFORM |
| 42 | Web-Based Physical Activity Interventions Are Feasible and Beneficial Solutions to Prevent Physical and Mental Health Declines in Community-Dwelling Older Adults During Isolation Periods | Granet J; Peyrusqué E; Ruiz F; Buckinx F; Abdelkader LB; Dang-Vu TT; Sirois MJ; Gouin JP; Pageaux B; Aubertin-Leheudre M; | 35675174 PERFORM |
| 43 | A portrait of obstructive sleep apnea risk factors in 27,210 middle-aged and older adults in the Canadian Longitudinal Study on Aging | Thompson C; Legault J; Moullec G; Baltzan M; Cross N; Dang-Vu TT; Martineau-Dussault MÈ; Hanly P; Ayas N; Lorrain D; Einstein G; Carrier J; Gosselin N; | 35332170 PERFORM |
| 44 | An altered balance of integrated and segregated brain activity is a marker of cognitive deficits following sleep deprivation | Cross NE; Pomares FB; Nguyen A; Perrault AA; Jegou A; Uji M; Lee K; Razavipour F; Ali OBK; Aydin U; Benali H; Grova C; Dang-Vu TT; | 34735431 PERFORM |
| 45 | The effects of evening high-intensity exercise on sleep in healthy adults: A systematic review and meta-analysis | Frimpong E; Mograss M; Zvionow T; Dang-Vu TT; | 34416428 PERFORM |
| 46 | Data-driven beamforming technique to attenuate ballistocardiogram artefacts in electroencephalography-functional magnetic resonance imaging without detecting cardiac pulses in electrocardiography recordings | Uji M; Cross N; Pomares FB; Perrault AA; Jegou A; Nguyen A; Aydin U; Lina JM; Dang-Vu TT; Grova C; | 34101939 PERFORM |
| 47 | Neural correlates of resilience to the effects of hippocampal atrophy on memory. | Belleville S, Mellah S, Cloutier S, Dang-Vu TT, Duchesne S, Maltezos S, Phillips N, Hudon C, CIMA-Q group | 33360019 HKAP |
| 48 | Cortical gradients of functional connectivity are robust to state-dependent changes following sleep deprivation. | Cross N; Paquola C; Pomares FB; Perrault AA; Jegou A; Nguyen A; Aydin U; Bernhardt BC; Grova C; Dang-Vu TT; | 33186718 PERFORM |
| 49 | Behavioral and Psychological Symptoms that Predict Cognitive Decline or Impairment in Cognitively Normal Middle-Aged or Older Adults: a Meta-Analysis. | Hudon C, Escudier F, De Roy J, Croteau J, Cross N, Dang-Vu TT, Zomahoun HTV, Grenier S, Gagnon JF, Parent A, Bruneau MA, Belleville S, Consortium for the Early Identification of Alzheimer’s Disease – Quebec | 32394109 HKAP |
| 50 | More than a quarter century of the most prescribed sleeping pill: Systematic review of zolpidem use by older adults. | Machado FV, Louzada LL, Cross NE, Camargos EF, Dang-Vu TT, Nóbrega OT | 32360985 PERFORM |
| 51 | Exercising before a nap benefits memory better than napping or exercising alone. | Mograss M, Crosetta M, Abi-Jaoude J, Frolova E, Robertson E, Pepin V, Dang-Vu TT | 32236442 PERFORM |
| 52 | Failure of fear extinction in insomnia: An evolutionary perspective. | Perogamvros L, Castelnovo A, Samson D, Dang-Vu TT | 32143023 PERFORM |
| 53 | Effects of Dance/Movement Training vs. Aerobic Exercise Training on cognition, physical fitness and quality of life in older adults: A randomized controlled trial. | Esmail A, Vrinceanu T, Lussier M, Predovan D, Berryman N, Houle J, Karelis A, Grenier S, Minh Vu TT, Villalpando JM, Bherer L | 31987547 PERFORM |
| 54 | Effects of menopause on sleep quality and sleep disorders: Canadian Longitudinal Study on Aging. | Zolfaghari S, Yao C, Thompson C, Gosselin N, Desautels A, Dang-Vu TT, Postuma RB, Carrier J | 31851117 PERFORM |
| 55 | Brain Rhythms During Sleep and Memory Consolidation: Neurobiological Insights. | Marshall L, Cross N, Binder S, Dang-Vu TT | 31799908 PERFORM |
| 56 | Beyond sleepy: structural and functional changes of the default-mode network in idiopathic hypersomnia. | Pomares FB, Boucetta S, Lachapelle F, Steffener J, Montplaisir J, Cha J, Kim H, Dang-Vu TT | 31328786 PERFORM |
| 57 | Spindle Oscillations in Sleep Disorders: A Systematic Review. | Weiner OM, Dang-Vu TT | 27034850 PERFORM |
| 58 | Structural Brain Alterations Associated with Rapid Eye Movement Sleep Behavior Disorder in Parkinson's Disease. | Boucetta S, Salimi A, Dadar M, Jones BE, Collins DL, Dang-Vu TT | 27245317 PERFORM |
| 59 | Cerebral Activity Associated with Transient Sleep-Facilitated Reduction in Motor Memory Vulnerability to Interference. | Albouy G, King BR, Schmidt C, Desseilles M, Dang-Vu TT, Balteau E, Phillips C, Degueldre C, Orban P, Benali H, Peigneux P, Luxen A, Karni A, Doyon J, Maquet P, Korman M | 27725727 PERFORM |
| 60 | High-Frequency Heart Rate Variability Reactivity and Trait Worry Interact to Predict the Development of Sleep Disturbances in Response to a Naturalistic Stressor. | MacNeil S, Deschênes SS, Caldwell W, Brouillard M, Dang-Vu TT, Gouin JP | 28527014 PERFORM |
| 61 | Sleep spindles may predict response to cognitive-behavioral therapy for chronic insomnia | Dang-Vu TT; Hatch B; Salimi A; Mograss M; Boucetta S; O' Byrne J; Brandewinder M; Berthomier C; Gouin JP; | 29157588 PERFORM |
| 62 | The Role of Sleep in Learning Placebo Effects. | Chouchou F, Dang-Vu TT, Rainville P, Lavigne G | 30146053 PERFORM |
| 63 | Cortical reactivations during sleep spindles following declarative learning. | Jegou A, Schabus M, Gosseries O, Dahmen B, Albouy G, Desseilles M, Sterpenich V, Phillips C, Maquet P, Grova C, Dang-Vu TT | 30928690 PERFORM |
| 64 | Sleep deprivation impairs inhibitory control during wakefulness in adult sleepwalkers. | Labelle MA, Dang-Vu TT, Petit D, Desautels A, Montplaisir J, Zadra A | 26087833 PERFORM |
| 65 | Cortical Thinning and Altered Cortico-Cortical Structural Covariance of the Default Mode Network in Patients with Persistent Insomnia Symptoms. | Suh S, Kim H, Dang-Vu TT, Joo E, Shin C | 26414892 PERFORM |
| 66 | What Is the Link Between Hallucinations, Dreams, and Hypnagogic-Hypnopompic Experiences? | Waters F, Blom JD, Dang-Vu TT, Cheyne AJ, Alderson-Day B, Woodruff P, Collerton D | 27358492 PERFORM |
| 67 | Psychiatric Illness and Parasomnias: a Systematic Review. | Waters F, Moretto U, Dang-Vu TT | 28534293 PERFORM |
| 68 | Association between insomnia disorder and cognitive function in middle-aged and older adults: a cross-sectional analysis of the Canadian Longitudinal Study on Aging | Cross NE; Carrier J; Postuma RB; Gosselin N; Kakinami L; Thompson C; Chouchou F; Dang-Vu TT; | 31089710 PERFORM |
| 69 | Relationships between lower body strength and the energy cost of treadmill walking in a cohort of healthy older adults: a cross-sectional analysis. | Berryman N, Bherer L, Nadeau S, Lauzière S, Lehr L, Bobeuf F, Kergoat MJ, Vu TT, Bosquet L | 27815704 PERFORM |
| 70 | Altered Regional Cerebral Blood Flow in Idiopathic Hypersomnia. | Boucetta S, Montplaisir J, Zadra A, Lachapelle F, Soucy JP, Gravel P, Dang-Vu TT | 28958044 PERFORM |
| 71 | Altered brain perfusion patterns in wakefulness and slow-wave sleep in sleepwalkers. | Desjardins MÈ, Baril AA, Soucy JP, Dang-Vu TT, Desautels A, Petit D, Montplaisir J, Zadra A | 29514303 PERFORM |
| Title: | The interplay between orexin, neurodegeneration, cognition and sleep microarchitecture in mild to moderate Alzheimer's Disease | ||||
| Authors: | Paez A, Piñol-Ripoll G, Dogaheh SB, Gillman SO, Dakterzada F, Carnes A, Barbe F, Dang-Vu TT | ||||
| Link: | pubmed.ncbi.nlm.nih.gov/41512277/ | ||||
| DOI: | 10.1002/alz70856_107602 | ||||
| Publication: | Alzheimer s & dementia : the journal of the Alzheimer s Association | ||||
| Keywords: | |||||
| PMID: | 41512277 | Category: | Date Added: | 2026-01-09 | |
| Dept Affiliation: |
CONCORDIA
1 University of Oxford, Oxford, Oxfordshire, United Kingdom.2 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada.3 Concordia University, Montreal, QC, Canada.4 Institut de Recerca Biomédica de Lleida (IRBLLeida), Lleida, Spain.5 Cognitive Disorder Unit, Hospital Universitari Santa Maria, Lleida, Spain.6 Hospital Universitari Santa Maria de Lleida, IRBLleida, Lleida, Spain.7 Hospital Universitari Santa Maria LLeida, LLeida, Spain.8 Centre de recherche de l'Institut universitaire de gériatrie de Montréal, Montreal, QC, Canada. |
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Description: |
Background: Cerebrospinal fluid (CSF) orexin levels are higher in MCI and AD and associated with sleep deterioration, increasing risk of cognitive decline and Alzheimer's disease (AD) progression. Orexin-A is a key sleep-wake cycle regulator. Dual orexin receptor antagonists improve sleep in AD and insomnia and may reduce tau and Aß deposition in older adults. However, little research has investigated associations between sleep microarchitecture, orexin, neurodegeneration biomarkers, cognitive decline, or mental health in AD. Methods: Using data from a prospective cohort study of mild-to-moderate AD (n = 60, 30-female, mean age-74.7), we analysed non-REM sleep spindles, slow oscillations (SO), and their associations with CSF orexin, AD biomarkers, cognition, and mental health over three years. Participants underwent polysomnography (PSG) and CSF draws at baseline, neuropsychological assessment with the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) and Neuropsychiatric Inventory (NPI) at baseline and 12 months, and Mini-Mental Status Examination (MMSE) at baseline, 12, 24, and 36 months. PSG was scored along American Academy of Sleep Medicine guidelines. Spindle and SO detection were performed using in-house, open-source software packages developed at Concordia University, following Moelle (2011) recommendations for spindles and Staresina's (2015) recommendations for SO. Associations between SO and spindle characteristics (duration, density, power, amplitude) and orexin, Aß42 and tau at baseline, and baseline orexin and cognition from baseline to 36 months were investigated with false discovery rate-adjusted generalised linear models, controlling for age, sex, apnea-hypopnea index. Results: We found previously unreported, predictive associations between SO, duration, density, amplitude, and CSF orexin. Orexin also predicted increased ptau181, total-tau, ptau/Aß42, total-tau/Aß42. Increased orexin predicted worse cognitive performance (higher ADAS-cog, lower MMSE) from baseline to 36-months and increased neuropsychiatric symptom severity (NPI) from baseline to 12 months. Orexin also moderates relationships between spindles, SO, cognition, and mental health. Conclusions: Orexin levels are associated with neurodegeneration biomarkers and cognitive deterioration in AD and moderate relationships between sleep microarchitecture and cognitive changes over time. Orexin may thus constitute a potential target for sleep-related interventions for cognition in neurodegenerative disorders. |
