PERFORM Publications

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Title		Authors	PubMed ID
1	Controlling Temozolomide Efficacy by Light-Dependent Inhibition of O sup 6 /sup ‑Methylguanine DNA Methyltransferase	Lopez-Miranda IR; Sim JI; Juneau G; Wilds CJ; Beharry AA;	41531960 CHEMBIOCHEM
2	DNA Replication across α-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase η	Tomar R; Ghodke PP; Patra A; Smyth E; Pontarelli A; Copp W; Guengerich FP; Chaput JJ; Wilds CJ; Stone MP; Egli M;	39259676 CHEMBIOCHEM
3	Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1	Kozlov G; Jiang J; Rutherford T; Noronha AM; Wilds CJ; Gehring K;	39016322 CHEMBIOCHEM
4	A chloromethyl-triazole fluorescent chemosensor for O6-methylguanine DNA methyltransferase	Ayan S; Rotaru AM; Kaye EG; Juneau G; Das S; Wilds CJ; Beharry AA;	38502038 CHEMBIOCHEM
5	C5-Propynyl modified 2'-fluoroarabinonucleic acids form stable duplexes with RNA that are RNase H competent	Pontarelli A; Wilds CJ;	37667655 CHEMBIOCHEM
6	Oligonucleotides Containing C5-Propynyl Modified Arabinonucleic Acids: Synthesis, Biophysical and Antisense Properties	Pontarelli A; Wilds CJ;	36857293 CHEMBIOCHEM
7	Preparation of a Convertible Spacer Containing a Disulfide Group for Versatile Functionalization of Oligonucleotides	Pontarelli A; Liu JT; Oh JK; Wilds CJ;	36840706 CHEMBIOCHEM
8	Structural basis of 3'-end poly(A) RNA recognition by LARP1	Kozlov G; Mattijssen S; Jiang J; Nyandwi S; Sprules T; Iben JR; Coon SL; Gaidamakov S; Noronha AM; Wilds CJ; Maraia RJ; Gehring K;	35979957 CHEMBIOCHEM
9	Synthesis of a Convertible Linker Containing a Disulfide Group for Oligonucleotide Functionalization	Pontarelli A; Liu JT; Movasat H; Ménard S; Oh JK; Wilds CJ;	35863757 CHEMBIOCHEM
10	Arabinonucleic Acids Containing C5-Propynyl Modifications Form Stable Hybrid Duplexes with RNA that are Efficiently Degraded by E. coli RNase H	Pontarelli A; Wilds CJ;	35452799 CHEMBIOCHEM
11	Generation of oligonucleotide conjugates via one-pot diselenide-selenoester ligation-deselenization/alkylation	Liczner C; Hanna CC; Payne RJ; Wilds CJ;	35126973 CHEMBIOCHEM
12	Beyond ribose and phosphate: Selected nucleic acid modifications for structure-function investigations and therapeutic applications	Liczner C; Duke K; Juneau G; Egli M; Wilds CJ;	33981365 CHEMBIOCHEM
13	Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing.	Copp W, Pontarelli A, Wilds CJ	33506614 CHEMBIOCHEM
14	O6-Alkylguanine DNA Alkyltransferase Mediated Disassembly of a DNA Tetrahedron.	Copp W, Wilds CJ	32543755 CHEMBIOCHEM
15	Hydrated electrons induce the formation of interstrand cross-links in DNA modified by cisplatin adducts	Behmand B; Noronha AM; Wilds CJ; Marignier JL; Mostafavi M; Wagner JR; Hunting DJ; Sanche L;	32211848 CHEMBIOCHEM
16	O4-alkyl-2'-deoxythymidine cross-linked DNA to probe recognition and repair by O6-alkylguanine DNA alkyltransferases.	McManus FP, O'Flaherty DK, Noronha AM, Wilds CJ	22850722 CHEMBIOCHEM
17	Preparation of covalently linked complexes between DNA and O(6)-alkylguanine-DNA alkyltransferase using interstrand cross-linked DNA.	McManus FP, Khaira A, Noronha AM, Wilds CJ	23347328 CHEMBIOCHEM
18	Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η opposite Intrastrand Cross-Linked DNA.	O'Flaherty DK, Guengerich FP, Egli M, Wilds CJ	26624500 CHEMBIOCHEM
19	O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage.	O'Flaherty DK, Wilds CJ	26692563 CHEMISTRY
20	Stabilization of i-motif structures by 2'-β-fluorination of DNA.	Assi HA, Harkness RW, Martin-Pintado N, Wilds CJ, Campos-Olivas R, Mittermaier AK, González C, Damha MJ	27166371 CHEMBIOCHEM
21	Sequence-dependent nanometer-scale conformational dynamics of individual RecBCD-DNA complexes.	Carter AR, Seaberg MH, Fan HF, Sun G, Wilds CJ, Li HW, Perkins TT	27220465 CHEMBIOCHEM
22	Lesion Orientation of O4-Alkylthymidine Influences Replication by Human DNA Polymerase η.	O'Flaherty DK, Patra A, Su Y, Guengerich FP, Egli M, Wilds CJ	27574558 CHEMBIOCHEM
23	Preparation of Intrastrand {G}O(6) -Alkylene-O(6) {G} Cross-Linked Oligonucleotides.	O'Flaherty DK, Wilds CJ	27584704 CHEMBIOCHEM
24	O6-2'-Deoxyguanosine-butylene-O6-2'-deoxyguanosine DNA Interstrand Cross-Links Are Replication-Blocking and Mutagenic DNA Lesions.	Xu W, Kool D, O'Flaherty DK, Keating AM, Sacre L, Egli M, Noronha A, Wilds CJ, Zhao L	27768841 CHEMBIOCHEM
25	Site-specific covalent capture of human O6-alkylguanine-DNA-alkyltransferase using single-stranded intrastrand cross-linked DNA.	O'Flaherty DK, Wilds CJ	27886318 CHEMBIOCHEM
26	Structural basis of interstrand cross-link repair by O6-alkylguanine DNA alkyltransferase.	Denisov AY, McManus FP, O'Flaherty DK, Noronha AM, Wilds CJ	28937154 CHEMBIOCHEM
27	Influence of nucleotide modifications at the C2' position on the Hoogsteen base-paired parallel-stranded duplex of poly(A) RNA.	Copp W, Denisov AY, Xie J, Noronha AM, Liczner C, Safaee N, Wilds CJ, Gehring K	28973475 CHEMBIOCHEM
28	AGT Activity Towards Intrastrand Crosslinked DNA is Modulated by the Alkylene Linker.	O'Flaherty DK, Wilds CJ	28980757 CHEMBIOCHEM
29	Altering Residue 134 Confers an Increased Substrate Range of Alkylated Nucleosides to the E. coli OGT Protein.	Schoonhoven NM, O'Flaherty DK, McManus FP, Sacre L, Noronha AM, Kornblatt MJ, Wilds CJ	29137116 CHEMBIOCHEM
30	Covalent capture of OGT's active site using engineered human-E. coli chimera and intrastrand DNA cross-links.	Copp W, O'Flaherty DK, Wilds CJ	30430154 CHEMBIOCHEM

Title:	AGT Activity Towards Intrastrand Crosslinked DNA is Modulated by the Alkylene Linker.
Authors:	O'Flaherty DK, Wilds CJ
Link:	https://www.ncbi.nlm.nih.gov/pubmed/28980757?dopt=Abstract
Publication:
Keywords:
PMID:	28980757	Category:	Chembiochem	Date Added:	2019-05-31
Dept Affiliation:	CHEMBIOCHEM 1 Department of Chemistry and Biochemistry, Concordia University Montreal, 7141 Sherbrooke Street W., Montreal, Quebec, H4B 1R6, Canada. 2 Present address: Howard Hughes Medical Institute, Department of Molecular Biology and, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, 02114, USA.

Description:

AGT Activity Towards Intrastrand Crosslinked DNA is Modulated by the Alkylene Linker.

Chembiochem. 2017 12 05;18(23):2351-2357

Authors: O'Flaherty DK, Wilds CJ

Abstract

DNA oligomers containing dimethylene and trimethylene intrastrand crosslinks (IaCLs) between the O4 and O6 atoms of neighboring thymidine (T) and 2'-deoxyguanosine (dG) residues were prepared by solid-phase synthesis. UV thermal denaturation (Tm ) experiments revealed that these IaCLs had a destabilizing effect on the DNA duplex relative to the control. Circular dichroism spectroscopy suggested these IaCLs induced minimal structural distortions. Susceptibility to dealkylation by reaction with various O6 -alkylguanine DNA alkyltransferases (AGTs) from human and Escherichia coli was evaluated. It was revealed that only human AGT displayed activity towards the IaCL DNA, with reduced efficiency as the IaCL shortened (from four to two methylene linkages). Changing the site of attachment of the ethylene linkage at the 5'-end of the IaCL to the N3 atom of T had minimal influence on duplex stability and structure, and was refractory to AGT activity.

PMID: 28980757 [PubMed - indexed for MEDLINE]

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