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"Behav Brain Res" Category Publications:

Title Authors PubMed ID
1 Effects of perirhinal cortex and hippocampal lesions on rats' performance on two object-recognition tasks. Cole E, Ziadé J, Simundic A, Mumby DG 31877339
PSYCHOLOGY
2 Parallel contributions of cerebellar, striatal and M1 mechanisms to motor sequence learning Penhune VB; Steele CJ; 22004979
PSYCHOLOGY
3 Repeated administration of estradiol promotes mechanisms of sexual excitation and inhibition: Glutamate signaling in the ventromedial hypothalamus attenuates excitation. Jones SL, Farisello L, Mayer-Heft N, Pfaus JG 26008158
PSYCHOLOGY
4 The neural substrates for the rewarding and dopamine-releasing effects of medial forebrain bundle stimulation have partially discrepant frequency responses. Cossette MP, Conover K, Shizgal P 26477378
CSBN
5 Effects of chronic prenatal MK-801 treatment on object recognition, cognitive flexibility, and drug-induced locomotor activity in juvenile and adult rat offspring. Gallant S, Welch L, Martone P, Shalev U 28390877
PSYCHOLOGY

 

Title:Effects of perirhinal cortex and hippocampal lesions on rats' performance on two object-recognition tasks.
Authors:Cole E,  Ziadé J,  Simundic A,  Mumby DG
Link:https://www.ncbi.nlm.nih.gov/pubmed/31877339?dopt=Abstract
DOI:10.1016/j.bbr.2019.112450
Publication:Behavioural brain research
Keywords:Hippocampus;  Novel-object preference;  Object-recognition;  Perirhinal cortex;  Rat; 
PMID:31877339 Category:Behav Brain Res Date Added:2019-12-27
Dept Affiliation: PSYCHOLOGY
1 Department of Psychology, Concordia University, Montréal, QC, Canada. Electronic address: e_cole@live.concordia.ca.
2 Department of Psychology, Concordia University, Montréal, QC, Canada.

Description:

Effects of perirhinal cortex and hippocampal lesions on rats' performance on two object-recognition tasks.

Behav Brain Res. 2019 Dec 23;:112450

Authors: Cole E, Ziadé J, Simundic A, Mumby DG

Abstract

The effects of hippocampal (HPC) damage on rats' novel object preference (NOP) performance have been rather consistent, in that HPC lesions do not disrupt novelty preferences on the test. Conversely, there have been inconsistent findings regarding the effects of perirhinal cortex (PRh) lesions on rats' novel-object preferences. Given the concerns that have been raised regarding the internal validity of the NOP test, viz. that the magnitude of the novel-object preference does not necessarily reflect the strength in memory for an object, it could explain the discrepant findings. The goal of the present experiment was to examine the effects of PRh and HPC lesions on rats' object-recognition memory using a new modified delayed nonmatching-to-sample (mDNMS) task, as it circumvents the interpretational problems associated with the NOP test. Rats received PRh, HPC, or Sham lesions and were trained on the mDNMS task using a short delay (~30?s). Both PRh and HPC rats acquired the task at the same rate as Sham rats, and reached a similar level of accuracy, indicating intact object-recognition. Thereafter, rats were tested on the NOP test using a 180-s delay. Rats with HPC lesions exhibited significant novel-object preferences, however, both the PRh and Sham rats failed to show a novelty preference. The discrepancy in both the PRh and Sham rats' performance on the mDNMS task and NOP test raises concerns regarding the internal validity of the NOP test, in that the magnitude of a rat's novel-object preference does not accurately reflect the persistence or accuracy of a rat's memory for the sample object.

PMID: 31877339 [PubMed - as supplied by publisher]




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