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"Cereb Cortex" Category Publications:

Title Authors PubMed ID
1 Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior. Reynolds LM, Yetnikoff L, Pokinko M, Wodzinski M, Epelbaum JG, Lambert LC, Cossette MP, Arvanitogiannis A, Flores C 30295713
PSYCHOLOGY
2 Optogenetic Activation of the Infralimbic Cortex Suppresses the Return of Appetitive Pavlovian-Conditioned Responding Following Extinction. Villaruel FR, Lacroix F, Sanio C, Sparks DW, Chapman CA, Chaudhri N 29045570
PSYCHOLOGY
3 Dissociation of Appetitive Overexpectation and Extinction in the Infralimic Cortex. Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD 30371757
CSBN
4 Corrigendum: Dissociation of Appetitive Overexpectation and Extinction in the Infralimbic Cortex. Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD 30590441
CSBN
5 Metabotropic Glutamate Receptor Type 5 (mGluR5) Cortical Abnormalities in Focal Cortical Dysplasia Identified In Vivo With [11C]ABP688 Positron-Emission Tomography (PET) Imaging. DuBois JM, Rousset OG, Guiot MC, Hall JA, Reader AJ, Soucy JP, Rosa-Neto P, Kobayashi E 27578494
PERFORM
6 Age Differences in the Neural Mechanisms of Intertemporal Choice Under Subjective Decision Conflict Eppinger B; Heekeren HR; Li SC; 29028956
PERFORM

 

Title:Optogenetic Activation of the Infralimbic Cortex Suppresses the Return of Appetitive Pavlovian-Conditioned Responding Following Extinction.
Authors:Villaruel FR,  Lacroix F,  Sanio C,  Sparks DW,  Chapman CA,  Chaudhri N
Link:https://www.ncbi.nlm.nih.gov/pubmed/29045570?dopt=Abstract
Publication:
Keywords:
PMID:29045570 Category:Cereb Cortex Date Added:2019-05-31
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology/FRQS Groupe de Recherche en Neurobiologie Comportementale, Department of Psychology, Concordia University, Montreal, Quebec, Canada.

Description:

Optogenetic Activation of the Infralimbic Cortex Suppresses the Return of Appetitive Pavlovian-Conditioned Responding Following Extinction.

Cereb Cortex. 2018 Dec 01;28(12):4210-4221

Authors: Villaruel FR, Lacroix F, Sanio C, Sparks DW, Chapman CA, Chaudhri N

Abstract

The infralimbic medial prefrontal cortex (IL) is important for suppressing learned behavior after extinction, but whether this function extends to responses acquired through appetitive Pavlovian conditioning is unclear. We trained male, Long-Evans rats to associate a white-noise conditional stimulus (CS; 10 s; 14 presentations per session) with 10% liquid sucrose (0.2 mL per CS presentation), and recorded entries into the fluid port during the CS. The CS was presented without sucrose in subsequent extinction and test sessions. Increasing IL activity with pretest microinfusions of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA; 0, 0.3 nmol; 0.3 µl/side) reduced the reinstatement of CS-elicited port entries. The same result was obtained when IL neurons that expressed Channelrhodopsin-2 (ChR2) were optically stimulated during CS presentations at test (473 nm, 5 ms pulses at 20 Hz for 10.2 s, unilateral). Optical stimulation of ChR2-expressing IL neurons during CS presentations also reduced spontaneous recovery and context-induced renewal. Furthermore, optical stimulation (1) during intertrial intervals had no impact on renewal, (2) depolarized ChR2-expressing IL pyramidal neurons in vitro, and (3) preferentially increased Fos in ChR2-expressing neurons. These novel converging data highlight a critical role for the IL in suppressing the return of appetitive Pavlovian-conditioned responding following extinction.

PMID: 29045570 [PubMed - in process]




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