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Title		Authors	PubMed ID
1	Effect of (Z)-isomer content on [11C]ABP688 binding potential in humans.	Smart K, Cox SML, Kostikov A, Shalai A, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M	30607444 CSBN
2	Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors.	Smart K, Cox SML, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M	30627817 CSBN
3	Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease.	Pascoal TA, Mathotaarachchi S, Shin M, Park AY, Mohades S, Benedet AL, Kang MS, Massarweh G, Soucy JP, Gauthier S, Rosa-Neto P, Alzheimer’s Disease Neuroimaging Initiative	29396637 PERFORM

Title:	Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors.
Authors:	Smart K, Cox SML, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M
Link:	https://www.ncbi.nlm.nih.gov/pubmed/30627817?dopt=Abstract
Publication:
Keywords:
PMID:	30627817	Category:	Eur J Nucl Med Mol Imaging	Date Added:	2019-05-31
Dept Affiliation:	CSBN 1 Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, QC, H3A 1A1, Canada. 2 Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. 3 Institute of Mental Health Research, affiliated with the University of Ottawa, Ottawa, ON, K1Z 7K4, Canada. 4 Department of Psychology, Université Laval, Quebec City, QC, G1V 0A6, Canada. 5 CHU Ste-Justine Research Center, Montreal, QC, H3T 1C5, Canada. 6 Department of Psychiatry and Addiction, Université de Montréal, Montreal, QC, H3T 1J4, Canada. 7 Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada. 8 Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, QC, H3A 1A1, Canada. marco.leyton@mcgill.ca. 9 CHU Ste-Justine Research Center, Montreal, QC, H3T 1C5, Canada. marco.leyton@mcgill.ca. 10 Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada. marco.leyton@mcgill.ca. 11 Department of Psychology, McGill University, Montreal, QC, H3G 1G1, Canada. marco.leyton@mcgill.ca. 12 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, H4B 1R6, Canada. marco.leyton@mcgill.ca.

Description:

Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors.

Eur J Nucl Med Mol Imaging. 2019 May;46(5):1179-1183

Authors: Smart K, Cox SML, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M

Abstract

PURPOSE: The purpose of this study was to assess, in a large sample of healthy young adults, sex differences in the binding potential of [11C]ABP688, a positron emission tomography (PET) tracer selective for the metabotropic glutamate type 5 (mGlu5) receptor.

METHODS: High resolution [11C]ABP688 PET scans were acquired in 74 healthy volunteers (25 male, 49 female, mean age 20?±?3.0). Mean binding potential (BPND?=?fND * (Bavail / KD)) values were calculated in the prefrontal cortex, striatum, and limbic regions using the simplified reference tissue model with cerebellar grey matter as the reference region.

RESULTS: [11C]ABP688 BPND was significantly higher in men compared to women in the prefrontal cortex (p?<?0.01), striatum (p?<?0.001), and hippocampus (p?<?0.05). Whole-brain BPND was 17% higher in men. BPND was not related to menstrual phase in women.

CONCLUSIONS: Binding availability of mGlu5 receptors as measured by PET [11C]ABP688 is higher in healthy men than women. This likely represents a source of variability in [11C]ABP688 studies and could have relevance for sex differences in cognitive-behavioral functions and neuropsychiatric disorders.

PMID: 30627817 [PubMed - in process]

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