PERFORM Publications

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Title		Authors	PubMed ID
1	Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins.	Hayward DA, Pomares F, Casey KF, Ismaylova E, Levesque M, Greenlaw K, Vitaro F, Brendgen M, Rénard F, Dionne G, Boivin M, Tremblay RE, Booij L	32881198 PSYCHOLOGY
2	Accuracy and spatial properties of distributed magnetic source imaging techniques in the investigation of focal epilepsy patients.	Pellegrino G, Hedrich T, Porras-Bettancourt M, Lina JM, Aydin Ü, Hall J, Grova C, Kobayashi E	32386115 PERFORM
3	Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins.	Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L	28032437 PSYCHOLOGY
4	Intracranial EEG potentials estimated from MEG sources: A new approach to correlate MEG and iEEG data in epilepsy.	Grova C, Aiguabella M, Zelmann R, Lina JM, Hall JA, Kobayashi E	26931511 PERFORM
5	Source localization of the seizure onset zone from ictal EEG/MEG data.	Pellegrino G, Hedrich T, Chowdhury R, Hall JA, Lina JM, Dubeau F, Kobayashi E, Grova C	27059157 PERFORM
6	Clinical yield of magnetoencephalography distributed source imaging in epilepsy: A comparison with equivalent current dipole method.	Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C	29024165 PERFORM
7	Reproducibility of EEG-MEG fusion source analysis of interictal spikes: Relevance in presurgical evaluation of epilepsy.	Chowdhury RA, Pellegrino G, Aydin Ü, Lina JM, Dubeau F, Kobayashi E, Grova C	29164737 PERFORM
8	Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry.	Khalili-Mahani N, Rombouts SA, van Osch MJ, Duff EP, Carbonell F, Nickerson LD, Becerra L, Dahan A, Evans AC, Soucy JP, Wise R, Zijdenbos AP, van Gerven JM	28145075 PERFORM

Title:	Clinical yield of magnetoencephalography distributed source imaging in epilepsy: A comparison with equivalent current dipole method.
Authors:	Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C
Link:	https://www.ncbi.nlm.nih.gov/pubmed/29024165?dopt=Abstract
DOI:	10.1002/hbm.23837
Publication:	Human brain mapping
Keywords:	MEG; dipole; distributed source; interictal epileptiform discharges; magnetic source imaging; presurgical evaluation; source localization; spike; surgery;
PMID:	29024165	Category:	Hum Brain Mapp	Date Added:	2019-06-04
Dept Affiliation:	PERFORM 1 Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University, Montreal, Quebec, Canada. 2 Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. 3 IRCCS Fondazione San Camillo Hospital, Venice, Italy. 4 Departement de Génie Electrique, Ecole de Technologie Supérieure, Montreal, Quebec, Canada. 5 Centre De Recherches En Mathématiques, Montreal, Quebec, Canada. 6 Centre D'études Avancées En Médecine Du Sommeil, Centre De Recherche De L'hôpital Sacré-Coeur De Montréal, Montreal, Quebec, Canada. 7 Physics Department and PERFORM Centre, Concordia University, Montreal, Quebec, Canada.

Description:

Clinical yield of magnetoencephalography distributed source imaging in epilepsy: A comparison with equivalent current dipole method.

Hum Brain Mapp. 2018 01;39(1):218-231

Authors: Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C

Abstract

OBJECTIVE: Source localization of interictal epileptic discharges (IEDs) is clinically useful in the presurgical workup of epilepsy patients. It is usually obtained by equivalent current dipole (ECD) which localizes a point source and is the only inverse solution approved by clinical guidelines. In contrast, magnetic source imaging using distributed methods (dMSI) provides maps of the location and the extent of the generators, but its yield has not been clinically validated. We systematically compared ECD versus dMSI performed using coherent Maximum Entropy on the Mean (cMEM), a method sensitive to the spatial extent of the generators.

METHODS: 340 source localizations of IEDs derived from 49 focal epilepsy patients with foci well-defined through intracranial EEG, MRI lesions, and surgery were analyzed. The comparison was based on the assessment of the sublobar concordance with the focus and of the distance between the source and the focus.

RESULTS: dMSI sublobar concordance was significantly higher than ECD (81% vs 69%, P?<?0.001), especially for extratemporal lobe sources (dMSI?=?84%; ECD?=?67%, P?<?0.001) and for seizure free patients (dMSI?=?83%; ECD?=?70%, P?<?0.001). The median distance from the focus was 4.88 mm for ECD and 3.44 mm for dMSI (P?<?0.001). ECD dipoles were often wrongly localized in deep brain regions.

CONCLUSIONS: dMSI using cMEM exhibited better accuracy. dMSI also offered the advantage of recovering more realistic maps of the generator, which could be exploited for neuronavigation aimed at targeting invasive EEG and surgical resection. Therefore, dMSI may be preferred to ECD in clinical practice. Hum Brain Mapp 39:218-231, 2018. © 2017 Wiley Periodicals, Inc.

PMID: 29024165 [PubMed - indexed for MEDLINE]

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