PERFORM Publications

Keyword search (4,163 papers available)

Title		Authors	PubMed ID
1	Resources and Methods for Engineering "Designer" Glycan-Binding Proteins.	Warkentin R, Kwan DH	33450899 CHEMBIOCHEM
2	Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease.	Millet-Boureima C; Rozencwaig R; Polyak F; Gamberi C;	33238462 BIOLOGY
3	Gold Nano-Island Platforms for Localized Surface Plasmon Resonance Sensing: A Short Review.	Badilescu S, Raju D, Bathini S, Packirisamy M	33066088 ENCS
4	Angiotensin-I-Converting Enzyme Inhibitory Activity of Coumarins from Angelica decursiva.	Ali MY, Seong SH, Jung HA, Choi JS	31683604 CHEMBIOCHEM
5	Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators.	Said Fatahala S, Hasabelnaby S, Goudah A, Mahmoud GI, Helmy Abd-El Hameed R	28304349 CHEMBIOCHEM
6	Altering Residue 134 Confers an Increased Substrate Range of Alkylated Nucleosides to the E. coli OGT Protein.	Schoonhoven NM, O'Flaherty DK, McManus FP, Sacre L, Noronha AM, Kornblatt MJ, Wilds CJ	29137116 CHEMBIOCHEM

Title:	Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators.
Authors:	Said Fatahala S, Hasabelnaby S, Goudah A, Mahmoud GI, Helmy Abd-El Hameed R
Link:	https://www.ncbi.nlm.nih.gov/pubmed/28304349?dopt=Abstract
Publication:
Keywords:
PMID:	28304349	Category:	Molecules	Date Added:	2019-05-31
Dept Affiliation:	CHEMBIOCHEM 1 Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ain-Helwan, Helwan 11795, Cairo, Egypt. samarradwan1@yahoo.com. 2 Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain-Helwan, Helwan 11795, Cairo, Egypt. sherifajanaa@yahoo.com. 3 Department of Chemistry and Biochemistry, Concordia University, 7141 rue Sherbrooke O., Montréal, H4Bm1R6 QC, Canada. sherifajanaa@yahoo.com. 4 Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza/Egypt, Giza 12211, Egypt. aymangouda@yahoo.com. 5 Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza/Egypt, Giza 12211, Egypt. ssfathallah@yahoo.com. 6 Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ain-Helwan, Helwan 11795, Cairo, Egypt. zeiadomar@yahoo.com.

Description:

Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators.

Molecules. 2017 Mar 17;22(3):

Authors: Said Fatahala S, Hasabelnaby S, Goudah A, Mahmoud GI, Helmy Abd-El Hameed R

Abstract

A new series of pyrrolopyridines and pyrrolopyridopyrimidines have been synthesized from aminocyanopyrroles. The synthesized compounds have been characterized by FTIR, ¹H-NMR and mass spectroscopy. The final compounds have been screened for in vitro pro-inflammatory cytokine inhibitory and in vivo anti-inflammatory activity. The biological results revealed that among all tested compounds some fused pyrroles, namely the pyrrolopyridines 3i and 3l, show promising activity. A docking study of the active synthesized molecules confirmed the biological results and revealed a new binding pose in the COX-2 binding site.

PMID: 28304349 [PubMed - indexed for MEDLINE]

BookR: School of Health Core Facilities Booking

"Molecules" Category Publications:

Search Publications

No results