Keyword search (4,163 papers available)

"Nat Commun" Category Publications:

Title Authors PubMed ID
1 Auditory information enhances post-sensory visual evidence during rapid multisensory decision-making. Franzen L; Delis I; De Sousa G; Kayser C; Philiastides MG; 33116148
CONCORDIA
2 Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts. Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N 32724058
PSYCHOLOGY
3 A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids. Pyne ME, Kevvai K, Grewal PS, Narcross L, Choi B, Bourgeois L, Dueber JE, Martin VJJ 32620756
BIOLOGY
4 Evolving perspectives on the sources of the frequency-following response. Coffey EBJ, Nicol T, White-Schwoch T, Chandrasekaran B, Krizman J, Skoe E, Zatorre RJ, Kraus N 31695046
PSYCHOLOGY
5 Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator. Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA 31604953
BIOLOGY
6 Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease. Hadoux X, Hui F, Lim JKH, Masters CL, Pébay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Lesage F, Sylvestre JP, Rosa-Neto P, Mathotaarachchi S, Gauthier S, Nasreddine ZS, Arbour JD, Rhéaume MA, Beaulieu S, Dirani M, Nguyen CTO, Bui BV, Williamson R, Crowston JG, van Wijngaarden P 31530809
PERFORM
7 Author Correction: Building a global alliance of biofoundries. Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Feuvre RL, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR, Johnson RA, Keasling JD, Kitney RI, Kondo A, Liu C, Martin VJJ, Menolascina F, Ogino C, Patron NJ, Pavan M, Poh CL, Pretorius IS, Rosser SJ, Scrutton NS, Storch M, Tekotte H, Travnik E, Vickers CE, Yew WS, Yuan Y, Zhao H, Freemont PS 31296848
CHEMBIOCHEM
8 Neural correlates of two different types of extinction learning in the amygdala central nucleus. Iordanova MD, Deroche ML, Esber GR, Schoenbaum G 27531638
CSBN
9 The intralumenal fragment pathway mediates ESCRT-independent surface transporter down-regulation. McNally EK, Brett CL 30560896
BIOLOGY
10 A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host. Harding CM, Nasr MA, Scott NE, Goyette-Desjardins G, Nothaft H, Mayer AE, Chavez SM, Huynh JP, Kinsella RL, Szymanski CM, Stallings CL, Segura M, Feldman MF 30792408
BIOLOGY
11 Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae. Fossati E, Ekins A, Narcross L, Zhu Y, Falgueyret JP, Beaudoin GA, Facchini PJ, Martin VJ 24513861
BIOLOGY
12 Giant electron-hole transport asymmetry in ultra-short quantum transistors. McRae AC, Tayari V, Porter JM, Champagne AR 28561024
PHYSICS
13 Building a global alliance of biofoundries. Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Le Feuvre R, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR, Johnson RA, Keasling JD, Kitney RI, Kondo A, Liu C, Martin VJJ, Menolascina F, Ogino C, Patron NJ, Pavan M, Poh CL, Pretorius IS, Rosser SJ, Scrutton NS, Storch M, Tekotte H, Travnik E, Vickers CE, Yew WS, Yuan Y, Zhao H, Freemont PS 31068573
CHEMBIOCHEM

 

Title:The intralumenal fragment pathway mediates ESCRT-independent surface transporter down-regulation.
Authors:McNally EKBrett CL
Link:https://www.ncbi.nlm.nih.gov/pubmed/30560896?dopt=Abstract
DOI:10.1038/s41467-018-07734-5
Publication:Nature communications
Keywords:
PMID:30560896 Category:Nat Commun Date Added:2019-06-07
Dept Affiliation: BIOLOGY
1 Department of Biology, Concordia University, 7141 Sherbrooke St. W., SP-501.15, Montréal, QC, H4R 1R6, Canada.
2 Department of Biology, Concordia University, 7141 Sherbrooke St. W., SP-501.15, Montréal, QC, H4R 1R6, Canada. christopher.brett@concordia.ca.

Description:

The intralumenal fragment pathway mediates ESCRT-independent surface transporter down-regulation.

Nat Commun. 2018 12 18;9(1):5358

Authors: McNally EK, Brett CL

Abstract

Surface receptor and transporter protein down-regulation is assumed to be exclusively mediated by the canonical multivesicular body (MVB) pathway and ESCRTs (Endosomal Sorting Complexes Required for Transport). However, few surface proteins are known to require ESCRTs for down-regulation, and reports of ESCRT-independent degradation are emerging, suggesting that alternative pathways exist. Here, using Saccharomyces cerevisiae as a model, we show that the hexose transporter Hxt3 does not require ESCRTs for down-regulation conferring resistance to 2-deoxyglucose. This is consistent with GFP-tagged Hxt3 bypassing ESCRT-mediated entry into intralumenal vesicles at endosomes. Instead, Hxt3-GFP accumulates on vacuolar lysosome membranes and is sorted into an area that, upon fusion, is internalized as an intralumenal fragment (ILF) and degraded. Moreover, heat stress or cycloheximide trigger degradation of Hxt3-GFP and other surface transporter proteins (Itr1, Aqr1) by this ESCRT-independent process. How this ILF pathway compares to the MVB pathway and potentially contributes to physiology is discussed.

PMID: 30560896 [PubMed - indexed for MEDLINE]





BookR developed by Sriram Narayanan
for the Concordia University School of Health
Copyright © 2011-2026
Cookie settings
Concordia University