Keyword search (4,163 papers available)

"Psychoneuroendocrinology" Category Publications:

Title Authors PubMed ID
1 Appetitive olfactory conditioning in the neonatal male rat facilitates subsequent sexual partner preference. Ménard S, Gelez H, Jacubovitch M, Coria-Avila GA, Pfaus JG 32919208
PSYCHOLOGY
2 Stress-Related Trajectories of Diurnal Cortisol in Older Adulthood Over 12 Years. Herriot H, Wrosch C, Hamm JM, Pruessner JC 32866774
CONCORDIA
3 Disaster-related prenatal maternal stress predicts HPA reactivity and psychopathology in adolescent offspring: Project Ice Storm. Yong Ping E, Laplante DP, Elgbeili G, Jones SL, Brunet A, King S 32442863
PSYCHOLOGY
4 The non-aromatizable androgen dihydrotestosterone (DHT) facilitates sexual behavior in ovariectomized female rats primed with estradiol. Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG 32087523
PSYCHOLOGY
5 Interpersonal capitalization moderates the associations of chronic caregiving stress and depression with inflammation. Gouin JP, Wrosch C, McGrath J, Booij L 31744782
PSYCHOLOGY
6 Modulation of spatial and response strategies by phase of the menstrual cycle in women tested in a virtual navigation task. Hussain D, Hanafi S, Konishi K, Brake WG, Bohbot VD 27213559
PSYCHOLOGY
7 Peripheral DNA methylation of HPA axis-related genes in humans: Cross-tissue convergence, two-year stability and behavioural and neural correlates. Di Sante J, Ismaylova E, Nemoda Z, Gouin JP, Yu WJ, Caldwell W, Vitaro F, Szyf M, Tremblay RE, Booij L 30059826
PSYCHOLOGY
8 Dehydroepiandrosterone impacts working memory by shaping cortico-hippocampal structural covariance during development. Nguyen TV, Wu M, Lew J, Albaugh MD, Botteron KN, Hudziak JJ, Fonov VS, Collins DL, Campbell BC, Booij L, Herba C, Monnier P, Ducharme S, McCracken JT 28946055
PSYCHOLOGY
9 Automatic and effortful emotional information processing regulates different aspects of the stress response. Ellenbogen MA, Schwartzman AE, Stewart J, Walker CD 16289608
PSYCHOLOGY
10 Daytime cortisol and stress reactivity in the offspring of parents with bipolar disorder. Ellenbogen MA, Hodgins S, Walker CD, Couture S, Adam S 17055665
CRDH
11 Structure provided by parents in middle childhood predicts cortisol reactivity in adolescence among the offspring of parents with bipolar disorder and controls. Ellenbogen MA, Hodgins S 19193493
CRDH
12 Intranasal oxytocin attenuates the cortisol response to physical stress: a dose-response study. Cardoso C, Ellenbogen MA, Orlando MA, Bacon SL, Joober R 22889586
PSYCHOLOGY
13 Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms. Ellenbogen MA, Linnen AM, Cardoso C, Joober R 22902063
PSYCHOLOGY
14 Salivary cortisol and interpersonal functioning: an event-contingent recording study in the offspring of parents with bipolar disorder. Ellenbogen MA, Linnen AM, Santo JB, aan het Rot M, Hodgins S, Young SN 23131593
PSYCHOLOGY
15 Stress-induced negative mood moderates the relation between oxytocin administration and trust: evidence for the tend-and-befriend response to stress? Cardoso C, Ellenbogen MA, Serravalle L, Linnen AM 23768973
PSYCHOLOGY
16 Oxytocin and psychotherapy: keeping context and person in mind. Cardoso C, Ellenbogen MA 24035601
PSYCHOLOGY
17 Tend-and-befriend is a beacon for change in stress research: a reply to Tops. Cardoso C, Ellenbogen MA 24755423
PSYCHOLOGY
18 The impact of attentional training on the salivary cortisol and alpha amylase response to psychosocial stress: importance of attentional control. Pilgrim K, Ellenbogen MA, Paquin K 24767623
PSYCHOLOGY
19 A meta-analytic review of the impact of intranasal oxytocin administration on cortisol concentrations during laboratory tasks: moderation by method and mental health. Cardoso C, Kingdon D, Ellenbogen MA 25086828
PSYCHOLOGY
20 Memory response to oxytocin predicts relationship dissolution over 18 months. Cardoso C, Kalogeropoulos C, Brown CA, Orlando MA, Ellenbogen MA 26986091
PSYCHOLOGY
21 Oxytocin and social context moderate social support seeking in women during negative memory recall. Cardoso C, Valkanas H, Serravalle L, Ellenbogen MA 27164224
PSYCHOLOGY
22 Successful aging, cognitive function, socioeconomic status, and leukocyte telomere length. Huang Y, Yim OS, Lai PS, Yu R, Chew SH, Gwee X, Nyunt MSZ, Gao Q, Ng TP, Ebstein RP, Gouin JP 30708136
PSYCHOLOGY
23 Facilitation of sexual behavior in ovariectomized rats by estradiol and testosterone: A preclinical model of androgen effects on female sexual desire. Jones SL, Ismail N, Pfaus JG 28278441
PSYCHOLOGY

 

Title:The non-aromatizable androgen dihydrotestosterone (DHT) facilitates sexual behavior in ovariectomized female rats primed with estradiol.
Authors:Maseroli E,  Santangelo A,  Lara-Fontes B,  Quintana GR,  Mac Cionnaith CE,  Casarrubea M,  Ricca V,  Maggi M,  Vignozzi L,  Pfaus JG
Link:https://www.ncbi.nlm.nih.gov/pubmed/32087523?dopt=Abstract
DOI:10.1016/j.psyneuen.2020.104606
Publication:Psychoneuroendocrinology
Keywords:Dihydrotestosterone;  Estradiol;  Preclinical;  Rat;  Sexual desire;  Solicitation; 
PMID:32087523 Category:Psychoneuroendocrinology Date Added:2020-02-23
Dept Affiliation: PSYCHOLOGY
1 Andrology, Women's Endocrinology and Gender Incongruence Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, Florence 50139, Italy; Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC H4B 1R6 Canada.
2 Psychiatry Unit, Department of Health Sciences. University of Florence, Italy; Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.). Human Physiology Section "Giuseppe Pagano", Corso Tukory 129, Palermo 90134, Italy.
3 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC H4B 1R6 Canada; Centro De Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, VER 91193, Mexico.
4 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC H4B 1R6 Canada.
5 Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.). Human Physiology Section "Giuseppe Pagano", Corso Tukory 129, Palermo 90134, Italy.
6 Psychiatry Unit, Department of Health Sciences. University of Florence, Italy.
7 Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, Florence 50139, Italy; I.N.B.B., Biostructures and Biosystems National Institute, Viale Delle Medaglie d'Oro 305, Rome 00136, Italy.
8 Andrology, Women's Endocrinology and Gender Incongruence Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, Florence 50139, Italy; I.N.B.B., Biostructures and Biosystems National Institute, Viale Delle Medaglie d'Oro 305, Rome 00136, Italy. Electronic address: linda.vignozzi@unifi.it.

Description:

The non-aromatizable androgen dihydrotestosterone (DHT) facilitates sexual behavior in ovariectomized female rats primed with estradiol.

Psychoneuroendocrinology. 2020 Feb 07;115:104606

Authors: Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG

Abstract

It is still unclear whether Testosterone (T) increases sexual desire through a stimulation of the androgen receptor in relevant brain regions or through its conversion to estrogens. The aim of this study was to clarify the mechanisms of T facilitation of female sexual desire by assessing the effect of a non-aromatizable androgen (Dihydrotestosterone, DHT) in a validated animal model. Ovariectomized (OVX) Long-Evans rats were treated with oil (O) + O, 10 mcg Estradiol Benzoate (EB) + O, 10 mcg EB?+?500 mcg Progesterone (P), O?+?500 mcg DHT or 10 mcg EB?+?500 mcg DHT (n?=?12 per group). EB was administered 48?h, while P and DHT 4?h, prior to 4 sexual behavioral testing sessions in bisected unilevel pacing chambers. Appetitive behaviors (the frequencies of hops/darts and solicitations) were considered as the main outcome measure. Sexual receptivity indexes [lordosis magnitude, expressed as lordosis rating (LR), and lordosis quotient (LQ)], rejection responses, as well as mounts, intromissions and ejaculations received from the male were also coded. The probability of transition among sexual behaviors was evaluated by Transition Matrices; T-Pattern analysis was performed to detect hidden repeated temporal behavioral sequences. Preliminary analyses found no statistically significant differences between the O?+?O and EB?+?O groups, therefore we excluded the EB?+?O group from further analyses. Rats treated with EB?+?DHT displayed significantly more appetitive behaviors compared to negative controls (O?+?O and O?+?DHT), whereas no difference was observed between EB?+?DHT rats and positive controls (EB?+?P); noteworthy, a higher number of appetitive behaviors was observed in the O?+?DHT group compared to the O?+?O group. Furthermore, rats treated with EB?+?DHT showed significantly higher receptivity measures (LR and LQ) and received more mounts, intromissions and ejaculations compared to negative controls (O?+?O and O?+?DHT), to levels equivalent to EB?+?P. No differences were detected in female-male mounts or rejection responses among the 4 groups. Under a qualitative perspective, full solicitation was found exclusively in T-patterns of the EB?+?DHT group, which was also the only one to display T-patterns of higher order encompassing appetitive behaviors-only events. In conclusion, the administration of DHT in EB-primed OVX Long-Evans rats enhances sexual behavior measures. Specifically, DHT seems to stimulate sequences of appetitive behaviors separated from copulative/reproductive measures. Our data support an independent role of androgens in the facilitation of female sexual desire.

PMID: 32087523 [PubMed - as supplied by publisher]




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