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"Psychopharmacology (Berl)" Category Publications:

Title Authors PubMed ID
1 Acute caffeine reverses the disruptive effects of chronic fluoxetine on the sexual behavior of female and male rats. González Cautela BV; Quintana GR; Akerman J; Pfaus JG; 33242109
PSYCHOLOGY
2 Correction to: Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area. Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG 31919562
PSYCHOLOGY
3 A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction. D'Cunha TM, Chisholm A, Hryhorczuk C, Fulton S, Shalev U 31811350
PSYCHOLOGY
4 Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area. Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG 31359118
PSYCHOLOGY
5 Acute intranasal oxytocin improves positive self-perceptions of personality. Cardoso C, Ellenbogen MA, Linnen AM 22012170
CRDH
6 Vendor differences in alcohol consumption and the contribution of dopamine receptors to Pavlovian-conditioned alcohol-seeking in Long-Evans rats. Sparks LM, Sciascia JM, Ayorech Z, Chaudhri N 24096535
PSYCHOLOGY
7 Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones. Sedki F, Gardner Gregory J, Luminare A, D'Cunha TM, Shalev U 26246318
CSBN
8 Nicotine-induced enhancement of Pavlovian alcohol-seeking behavior in rats. Maddux JN, Chaudhri N 28011981
CSBN

 

Title:Nicotine-induced enhancement of Pavlovian alcohol-seeking behavior in rats.
Authors:Maddux JN,  Chaudhri N
Link:https://www.ncbi.nlm.nih.gov/pubmed/28011981?dopt=Abstract
Publication:
Keywords:
PMID:28011981 Category:Psychopharmacology (Berl) Date Added:2019-05-31
Dept Affiliation: CSBN
1 Department of Psychology, Center for Studies in Behavioral Neurobiology/FRQS Groupe de recherche en neurobiologie comportementale, Concordia University, 7141 Sherbrooke Street West, Room SP 244, Montreal, QC, H4B-1R6, Canada.
2 Department of Psychology, Center for Studies in Behavioral Neurobiology/FRQS Groupe de recherche en neurobiologie comportementale, Concordia University, 7141 Sherbrooke Street West, Room SP 244, Montreal, QC, H4B-1R6, Canada. nadia.chaudhri@concordia.ca.

Description:

Nicotine-induced enhancement of Pavlovian alcohol-seeking behavior in rats.

Psychopharmacology (Berl). 2017 Feb;234(4):727-738

Authors: Maddux JN, Chaudhri N

Abstract

RATIONALE: Nicotine enhances responding elicited by Pavlovian cues that predict positive outcomes.

OBJECTIVES: We tested the hypothesis that nicotine acting at nicotinic acetylcholine receptors (nAChRs) would augment Pavlovian alcohol-seeking.

METHODS: Male, Long-Evans rats with unrestricted access to food and water were acclimated to drinking 15% ethanol in their home cages and then given Pavlovian conditioning sessions in which each trial of a 15-s conditioned stimulus (CS, 12 trials/session) was paired with 0.2 ml of ethanol (unconditioned stimulus, US, 2.4 ml/session). Entries into a port where ethanol was delivered were used to assess conditioning. Control groups received explicitly unpaired trials of the CS and US. In experiment 1, systemic injections of saline (1 ml/kg) or nicotine (0.4 mg/kg, freebase) were administered before each session. In experiments 2 and 3, an identical regimen of saline or nicotine injections was administered before the start of Pavlovian conditioning sessions.

RESULTS: All paired groups acquired conditioned port-entry responding to the CS, indicative of Pavlovian alcohol-seeking, whereas unpaired control group did not. Pre-session nicotine injections increased CS port-entries relative to saline, only in the paired group. This nicotine-induced enhancement of Pavlovian alcohol-seeking was blocked by pre-treatment with the nAChR antagonist mecamylamine. Prior exposure to nicotine did not influence the subsequent acquisition of Pavlovian alcohol-seeking.

CONCLUSIONS: These findings highlight for the first time that nicotine acting at nAChRs augments Pavlovian alcohol-seeking, specifically in non-restricted rats. Individuals who smoke and drink may thus be particularly susceptible to alcohol cues that could trigger further drinking.

PMID: 28011981 [PubMed - indexed for MEDLINE]




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