Keyword search (4,163 papers available)

"Accumbens" Keyword-tagged Publications:

Title Authors PubMed ID
1 Activation of infralimbic cortex neurons projecting to the nucleus accumbens shell suppresses discriminative stimulus-triggered relapse to cocaine seeking in rats Algallal HE; Laplante I; Casale D; Najafipashaki S; Pomerleau A; Paquette T; Samaha AN; 41372546
PSYCHOLOGY
2 Neural correlates of recall and extinction in a rat model of appetitive Pavlovian conditioning Brown A; Villaruel FR; Chaudhri N; 36496079
PSYCHOLOGY
3 The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands Howland JG; Ito R; Lapish CC; Villaruel FR; 35131398
PSYCHOLOGY
4 Corticostriatal suppression of appetitive Pavlovian conditioned responding Villaruel FR; Martins M; Chaudhri N; 34880119
PSYCHOLOGY
5 Off-Target Influences of Arch-Mediated Axon Terminal Inhibition on Network Activity and Behavior. Lafferty CK, Britt JP 32269514
CSBN
6 Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking. Lafferty CK, Yang AK, Mendoza JA, Britt JP 32187545
CSBN
7 Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability. Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP 31699294
CSBN
8 Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors. Voyer D, Lévesque D, Rompré PP 27267684
CSBN
9 Neurotensin in the nucleus accumbens reverses dopamine supersensitivity evoked by antipsychotic treatment. Servonnet A, Minogianis EA, Bouchard C, Bédard AM, Lévesque D, Rompré PP, Samaha AN 28522313
CSBN

 

Title:Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking.
Authors:Lafferty CK,  Yang AK,  Mendoza JA,  Britt JP
Link:https://www.ncbi.nlm.nih.gov/pubmed/32187545?dopt=Abstract
DOI:10.1016/j.celrep.2020.02.095
Publication:Cell reports
Keywords:basolateral amygdala;  behavioral inhibition;  direct pathway;  fiber photometry;  indirect pathway;  nucleus accumbens;  optogenetics;  paraventricular nucleus of the thalamus;  place preference;  self-stimulation; 
PMID:32187545 Category:Cell Rep Date Added:2020-03-19
Dept Affiliation: CSBN
1 Department of Psychology, McGill University, Montreal, QC, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.
2 Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.
3 Department of Psychology, McGill University, Montreal, QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada. Electronic address: jonathan.britt@mcgill.ca.

Description:

Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking.

Cell Rep. 2020 Mar 17;30(11):3729-3742.e3

Authors: Lafferty CK, Yang AK, Mendoza JA, Britt JP

Abstract

The nucleus accumbens (NAc) contributes to behavioral inhibition and compulsions, but circuit mechanisms are unclear. Recent evidence suggests that amygdala and thalamic inputs exert opposing control over behavior, much like direct and indirect pathway output neurons. Accordingly, opponent processes between these NAc inputs or cell types may underlie efficient reward seeking. We assess the contributions of these circuit elements to mouse operant behavior during recurring conditions when reward is and is not available. Although direct pathway stimulation is rewarding and indirect pathway stimulation aversive, the activity of both cell types is elevated during periods of behavioral suppression, and the inhibition of either cell-type selectively increases unproductive reward seeking. Amygdala and thalamic inputs are also necessary for behavioral suppression, even though they both support self-stimulation and innervate different NAc subregions. These data suggest that efficient reward seeking relies on complementary activity across NAc cell types and inputs rather than opponent processes between them.

PMID: 32187545 [PubMed - as supplied by publisher]




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