PERFORM Publications

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Title		Authors	PubMed ID
1	Effects of cognitive-behavioral therapy for insomnia during sedative-hypnotics withdrawal on sleep and cognition in older adults	Barbaux L; Cross NE; Perrault AA; Es-Sounni M; Desrosiers C; Clerc D; Andriamampionona F; Lussier D; Tannenbaum C; Guimond A; Grenier S; Gouin JP; Dang-Vu TT;	41092866 SOH
2	Perceptions et attitudes des personnes âgées souffrant d insomnie par rapport aux médicaments et aux produits de santé naturels	Nguyen PV; Dang-Vu T; Forest G; Saidi L; Desmarais P;	40968485 CONCORDIA
3	The temporal sequence and reciprocal relationships of frailty, social isolation and loneliness in older adults across 21 years	Mehrabi F; Pomeroy ML; Cudjoe TKM; Jenkins E; Dent E; Hoogendijk EO;	39360435 PSYCHOLOGY
4	The role of frailty in the relationships between social relationships and health outcomes: a longitudinal study	Fereshteh Mehrabi	38402184 PSYCHOLOGY
5	Slow oscillation-spindle cross-frequency coupling predicts overnight declarative memory consolidation in older adults	Oren M Weiner	37002805 PERFORM
6	Altered immunometabolism in adipose tissue: a major contributor to the ageing process?	Delaney KZ; Gillespie ZE; Murphy J; Wang C;	34159597 PERFORM
7	Obesity and ageing: Two sides of the same coin.	Tam BT, Morais JA, Santosa S	32020741 PERFORM

Title:	Obesity and ageing: Two sides of the same coin.
Authors:	Tam BT, Morais JA, Santosa S
Link:	https://www.ncbi.nlm.nih.gov/pubmed/32020741?dopt=Abstract
DOI:	10.1111/obr.12991
Publication:	Obesity reviews : an official journal of the International Association for the Study of Obesity
Keywords:	age-related diseases; ageing; obesity;
PMID:	32020741	Category:	Obes Rev	Date Added:	2020-02-06
Dept Affiliation:	PERFORM 1 Department of Health, Kinesiology, and Applied Physiology, Concordia University, Quebec, Montreal, Canada. 2 Metabolism, Obesity, and Nutrition Lab, PERFORM Centre, Concordia University, Quebec, Montreal, Canada. 3 Division of Geriatric Medicine and Research Institute, McGill University Health Centre, Quebec, Montreal, Canada. 4 Research Centre, Centre intégré universitarie de santé et de services sociaux du Nord-de-I'Île-de-Montréal, Hôpital du Sacré-Cœur de Monréal (CIUSS-NIM, HSCM), Quebec, Montreal, Canada.

Description:

Obesity and ageing: Two sides of the same coin.

Obes Rev. 2020 Feb 05;:

Authors: Tam BT, Morais JA, Santosa S

Abstract

Conditions and comorbidities of obesity mirror those of ageing and age-related diseases. Obesity and ageing share a similar spectrum of phenotypes such as compromised genomic integrity, impaired mitochondrial function, accumulation of intracellular macromolecules, weakened immunity, shifts in tissue and body composition, and enhanced systemic inflammation. Moreover, it has been shown that obesity reduces life expectancy by 5.8 years in men and 7.1 years in women after the age of 40. Shorter life expectancy could be because obesity holistically accelerates ageing at multiple levels. Besides jeopardizing nuclear DNA and mitochondrial DNA integrity, obesity modifies the DNA methylation pattern, which is associated with epigenetic ageing in different tissues. Additionally, other signs of ageing are seen in individuals with obesity including telomere shortening, systemic inflammation, and functional declines. This review aims to show how obesity and ageing are "two sides of the same coin" through discussing how obesity predisposes an individual to age-related conditions, illness, and disease. We will further demonstrate how the mechanisms that perpetuate the early-onset of chronic diseases in obesity parallel those of ageing.

PMID: 32020741 [PubMed - as supplied by publisher]

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